OPA1抗体;OPA1 Antibody—艾普蒂

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     Western blot analysis of OPA1 expression in HeLa cell lysate.    

  
  

**Background of OPA1 Antibody**

The OPA1 (Optic Atrophy 1) antibody is a crucial tool for studying the OPA1 protein, encoded by the *OPA1* gene, which plays a central role in mitochondrial dynamics and function. OPA1 is a dynamin-related GTPase essential for mitochondrial inner membrane fusion, cristae structure maintenance, and apoptosis regulation. Mutations in *OPA1* are linked to autosomal dominant optic atrophy (ADOA), a neurodegenerative disorder characterized by vision loss, and are associated with broader mitochondrial syndromes affecting the nervous system, muscles, and metabolism.

OPA1 antibodies are widely used in research to investigate mitochondrial morphology, bioenergetics, and quality control mechanisms. They enable the detection of OPA1 isoforms (long and short forms) via Western blotting, immunofluorescence, or immunohistochemistry, aiding in studies on mitochondrial fragmentation, oxidative stress, and cell death pathways. These antibodies also help explore OPA1’s interactions with proteins like MIC60 or prohibitin, which regulate cristae organization.

Additionally, OPA1 antibodies contribute to understanding disease mechanisms, therapeutic targets, and biomarkers in conditions like neurodegeneration, cancer, and metabolic disorders. Their specificity and reliability are critical for validating OPA1 expression patterns in cellular and animal models, advancing insights into mitochondrial dysfunction and potential interventions.