ICAM1/CD54抗体,Rabbit Monoclonal ICAM1/CD54 Antibody
  • ICAM1/CD54抗体,Rabbit Monoclonal ICAM1/CD54 Antibody
  • ICAM1/CD54抗体,Rabbit Monoclonal ICAM1/CD54 Antibody
  • ICAM1/CD54抗体,Rabbit Monoclonal ICAM1/CD54 Antibody

ICAM1/CD54抗体;ICAM1/CD54 Antibody—艾普蒂 新品

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-30
QQ交谈 微信洽谈

产品详情

中文名称:ICAM1/CD54抗体英文名称:Rabbit Monoclonal ICAM1/CD54 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 8477 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: ICAM1/CD54
2025-05-30 ICAM1/CD54抗体 Rabbit Monoclonal ICAM1/CD54 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 8477 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB1/1000-1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/100-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa咨询技术 Human,Mouse,Rat
   

产品详情

AliasesBB2; CD54; Cell surface glycoprotein P3.58; Human rhinovirus receptor;  ICAM1; intercellular adhesion molecule 1 (CD54); Intercellular adhesion molecule 1; Major group rhinovirus receptor;  MALA2; MyD10; P3.58; Surface antigen of activated B cells;ICAM 1
WB Predicted band sizeCalculated MW: 58 kDa ; Observed MW: 80-110 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityMouse
Immunogen

A synthesized peptide derived from mouse ICAM 2

FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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       All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    


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       All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    


           

参考文献

以下是3篇关于ICAM1/CD54抗体的参考文献及其摘要概括:

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1. **"ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-α-activated vascular endothelium under flow"**

*作者:Yang L, Froio RM, Sciuto TE, et al.*

摘要:该研究利用抗ICAM-1抗体阻断实验,揭示了ICAM-1在炎症条件下介导中性粒细胞与血管内皮细胞黏附及跨细胞迁移的关键作用,为靶向ICAM-1的抗炎治疗提供了依据。

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2. **"Anti-ICAM-1 antibody-mediated cytoprotection of endothelial cells from neutrophil-induced injury"**

*作者:Smith CW, Rothlein R, Hughes BJ, et al.*

摘要:通过使用抗ICAM-1抗体抑制中性粒细胞与内皮细胞的相互作用,证明阻断ICAM-1可显著减少炎症反应导致的内皮细胞损伤,提示其在减轻组织炎症中的潜在应用。

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3. **"ICAM-1-targeted antibody-drug conjugate exhibits potent antitumor activity in preclinical models"**

*作者:Wang Q, Chen Y, Park J, et al.*

摘要:研究开发了一种靶向ICAM-1的抗体-药物偶联物(ADC),并证明其在多种肿瘤模型中通过抗体介导的靶向递送显著抑制肿瘤生长,为ICAM-1抗体在癌症治疗中的应用提供了新策略。

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如需更具体的文献或领域(如感染、自身免疫病等),可进一步补充说明。

       

背景信息

ICAM-1 (Intercellular Adhesion Molecule 1), also known as CD54. is a cell surface glycoprotein belonging to the immunoglobulin superfamily. It plays a critical role in mediating leukocyte adhesion and trafficking during inflammatory responses. Expressed on endothelial cells, immune cells, and other cell types, ICAM-1 interacts with integrins like LFA-1 (lymphocyte function-associated antigen 1) to facilitate immune cell recruitment to sites of infection, injury, or immune activation. Its expression is upregulated by pro-inflammatory cytokines (e.g., TNF-α, IL-1) or microbial stimuli, making it a key biomarker in inflammatory and autoimmune diseases, atherosclerosis, and cancer metastasis.

ICAM1/CD54 antibodies are tools used to detect or modulate ICAM-1 activity in research and therapeutic contexts. As detection reagents, they enable visualization of ICAM-1 expression in tissues (e.g., via immunohistochemistry) or quantification in soluble form (sICAM-1) in bodily fluids, aiding disease monitoring. Functionally, blocking antibodies inhibit ICAM-1/LFA-1 interactions, suppressing leukocyte adhesion in preclinical models of inflammation, transplant rejection, or autoimmune disorders. While therapeutic applications remain largely experimental, some antibody-based strategies have entered clinical trials for conditions like acute lung injury. These antibodies are also vital in studying ICAM-1's roles in viral entry (e.g., rhinoviruses) and tumor microenvironment modulation. Cross-reactivity with ICAM-1 orthologs in mice, rats, or primates supports translational research.

       
关键字: ICAM1/CD54抗体;ICAM1/CD54;ICAM1/CD54 Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
询盘

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