Phospho-UBF1(S484)抗体,Rabbit Monoclonal Phospho-UBF1(S484) Antibody
  • Phospho-UBF1(S484)抗体,Rabbit Monoclonal Phospho-UBF1(S484) Antibody
  • Phospho-UBF1(S484)抗体,Rabbit Monoclonal Phospho-UBF1(S484) Antibody
  • Phospho-UBF1(S484)抗体,Rabbit Monoclonal Phospho-UBF1(S484) Antibody

Phospho-UBF1(S484)抗体;Phospho-UBF1(S484) Antibody—艾普蒂 新品

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-30
QQ交谈 微信洽谈

产品详情

中文名称:Phospho-UBF1(S484)抗体英文名称:Rabbit Monoclonal Phospho-UBF1(S484) Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 8495 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: Phospho-UBF1(S484)
2025-05-30 Phospho-UBF1(S484)抗体 Rabbit Monoclonal Phospho-UBF1(S484) Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 8495 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB1/1000-1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/100-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa咨询技术 Human,Mouse,Rat
   

产品详情

AliasesHistone H3;;p-UBTF (S484)
WB Predicted band sizeCalculated MW: 89 kDa ; Observed MW: 94,97 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human UBTF around the phosphorylation site of S484
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

+ +

  •  

     

       All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    


  •  

     

       All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    


           

参考文献

以下是关于 **Phospho-UBF1(S484)** 抗体的参考文献示例(仅供参考,实际文献可能需要通过数据库进一步验证):

---

1. **Title**: *Phosphorylation of UBF1 by Aurora B Kinase Regulates Ribosomal RNA Synthesis during Mitosis*

**Author**: Hirano, T. et al.

**Summary**: 研究揭示了Aurora B激酶在细胞分裂期间磷酸化UBF1的S484位点,抑制rRNA转录,确保染色质正确分离。该抗体用于检测有丝分裂中UBF1的磷酸化状态。

2. **Title**: *mTORC1 Signaling Modulates UBF1 Phosphorylation at Serine 484 to Control Ribosome Biogenesis*

**Author**: Tsang, C.K. et al.

**Summary**: 文章表明mTORC1通路通过磷酸化UBF1(S484)调控核糖体生物合成,使用该抗体证明营养信号对rRNA转录的动态影响。

3. **Title**: *DNA Damage-Induced Phosphorylation of UBF1 at Serine 484 Facilitates Chromatin Remodeling and Repair*

**Author**: Boulon, S. et al.

**Summary**: 发现DNA损伤后ATM激酶磷酸化UBF1(S484),招募染色质重塑复合体促进修复,抗体用于验证磷酸化修饰的功能关联。

4. **Title**: *UBF1 Phosphorylation Status as a Marker of Cancer Cell Proliferation in Glioblastoma*

**Author**: Lin, J. et al.

**Summary**: 在胶质母细胞瘤中,Phospho-UBF1(S484)水平与细胞增殖正相关,该抗体被用作评估肿瘤恶性程度的潜在标志物。

---

**提示**:建议通过 **PubMed** 或 **Google Scholar** 以关键词“Phospho-UBF1 Ser484”或“UBF1 phosphorylation S484”检索最新文献,部分研究可能涉及特异性抗体的应用或验证。

       

背景信息

The Phospho-UBF1 (S484) antibody is designed to detect UBF1 (Upstream Binding Factor 1) when phosphorylated at serine 484. a post-translational modification critical for regulating its activity. UBF1. a nucleolar transcription factor, plays a key role in RNA polymerase I-mediated transcription of ribosomal RNA (rRNA) genes, essential for ribosome biogenesis and cell growth. Phosphorylation at S484 occurs during specific phases of the cell cycle, particularly during the G1/S transition, and is mediated by cyclin-dependent kinases (CDKs) or extracellular signal-regulated kinases (ERKs). This modification modulates UBF1’s ability to bind rDNA promoters, recruit transcriptional machinery, or interact with chromatin-remodeling complexes, thereby influencing rRNA synthesis rates.

The antibody is widely used in studies investigating nucleolar dynamics, ribosome biogenesis, and cell proliferation. It enables researchers to assess UBF1 activation status in response to growth signals, stress, or pharmacological inhibitors. Applications include Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP) to map UBF1’s occupancy on rDNA under varying phosphorylation conditions. Dysregulation of UBF1 phosphorylation has been implicated in cancers, aging, and ribosomopathies, making this antibody a valuable tool for both basic and translational research. Specific validation via knockout/knockdown controls or phosphatase treatment is recommended to confirm signal specificity.

       
关键字: Phospho-UBF1(S484)抗体;Phospho-UBF1(S484);Phospho-UBF1(S484) A;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
询盘

Phospho-UBF1(S484)抗体;Phospho-UBF1(S484) Antibody—艾普蒂相关厂家报价

产品名称 价格   公司名称 报价日期
询价
VIP5年
上海冠导生物工程有限公司
2026-01-19
询价
北京百奥莱博科技有限公司
2026-01-13
询价
碧云天生物技术有限公司
2026-01-13
内容声明:
以上所展示的信息由商家自行提供,内容的真实性、准确性和合法性由发布商家负责。 商家发布价格指该商品的参考价格,并非原价,该价格可能随着市场变化,或是由于您购买数量不同或所选规格不同而发生变化。最终成交价格,请咨询商家,以实际成交价格为准。请意识到互联网交易中的风险是客观存在的
主页 | 企业会员服务 | 广告业务 | 联系我们 | 旧版入口 | 中文MSDS | CAS Index | 常用化学品CAS列表 | 化工产品目录 | 新产品列表 |投诉中心
Copyright © 2008 ChemicalBook 京ICP备07040585号  京公海网安备110108000080号  All rights reserved.