The SUN2 antibody is a crucial tool in studying the SUN domain-containing protein 2 (SUN2), a component of the linker of nucleoskeleton and cytoskeleton (LINC) complex. SUN2. encoded by the *SUN2* gene, is a transmembrane protein localized to the inner nuclear membrane. It plays a pivotal role in maintaining nuclear architecture, mediating mechanical connections between the nuclear lamina and the cytoskeleton via interactions with nesprins. SUN2 also participates in processes such as nuclear positioning, cell migration, and mechanotransduction.
The SUN2 antibody is widely used in research to detect and quantify SUN2 expression in various cell types and tissues through techniques like Western blotting, immunofluorescence, and immunohistochemistry. It helps investigate SUN2's involvement in cellular responses to mechanical stress, DNA repair, and cell cycle regulation. Dysregulation of SUN2 has been linked to pathologies including cancer, muscular dystrophies, and cardiovascular diseases, making its antibody valuable for exploring disease mechanisms. Available as monoclonal or polyclonal variants, SUN2 antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes (e.g., C-terminal domains). Validation includes knockout controls or siRNA knockdown to ensure specificity, supporting studies in cell biology, developmental biology, and pathophysiology.