FKBP52抗体;FKBP52 Antibody—艾普蒂

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     Western blot analysis of FKBP52 expression in MCF7 cell lysate.    

  
  

The FKBP52 antibody targets the FK506-binding protein 52 (FKBP52), a member of the immunophilin family known for its role as a molecular chaperone. FKBP52. encoded by the FKBP4 gene, is widely expressed in eukaryotic cells and participates in diverse cellular processes, including steroid hormone receptor signaling, protein folding, and intracellular trafficking. It contains an FK506-binding domain that enables peptidyl-prolyl isomerase (PPIase) activity and a tetratricopeptide repeat (TPR) domain that mediates interactions with heat shock protein 90 (HSP90). These structural features allow FKBP52 to regulate the functional maturation and ligand-binding capacity of steroid receptors, such as glucocorticoid and androgen receptors.

Research highlights FKBP52's involvement in physiological and pathological contexts. It is implicated in neurodegenerative diseases (e.g., tau aggregation in Alzheimer’s), cancer progression (via hormone-dependent pathways), and reproductive disorders (e.g., infertility). Antibodies against FKBP52 are essential tools for studying its expression, localization, and interactions in experimental models. They are widely used in techniques like Western blotting, immunoprecipitation, and immunohistochemistry to explore FKBP52's mechanistic roles. Additionally, FKBP52 antibodies hold potential for diagnostic applications, as altered FKBP52 levels correlate with certain diseases, and therapeutic strategies targeting FKBP52-HSP90 complexes are under investigation. Overall, FKBP52 antibodies serve as critical reagents in both basic research and translational studies.