MGEA5抗体,Rabbit Monoclonal MGEA5 Antibody
  • MGEA5抗体,Rabbit Monoclonal MGEA5 Antibody
  • MGEA5抗体,Rabbit Monoclonal MGEA5 Antibody
  • MGEA5抗体,Rabbit Monoclonal MGEA5 Antibody

MGEA5抗体;MGEA5 Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-30
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产品详情

中文名称:MGEA5抗体英文名称:Rabbit Monoclonal MGEA5 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 8605 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: MGEA5
2025-05-30 MGEA5抗体 Rabbit Monoclonal MGEA5 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 8605 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB1/1000-1/2000 Human,Mouse,Rat
IF1/20-1/50 Human,Mouse,Rat
IHC1/100-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa咨询技术 Human,Mouse,Rat
   

产品详情

AliasesHEXC; MEA5; Mgea5; NCOAT; OGA;;OGA
WB Predicted band sizeCalculated MW: 103 kDa ; Observed MW: 130 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthesized peptide derived from human OGA
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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       All lanes use the Antibody at 1:500 dilution for 1 hour at room temperature.    


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       Western blot analysis of MGEA5 expression in JAR cell lysate.    


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       Immunofluorescent analysis using the Antibody at 1:50 dilution.    


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       Immunofluorescent analysis using the Antibody at 1:50 dilution.    


           

参考文献

以下是3篇关于MGEA5(O-GlcNAcase)抗体的文献摘要信息:

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1. **文献名称**:*"O-GlcNAcase is essential for embryonic development and maintenance of genomic stability"*

**作者**:Janetzko J. et al.

**摘要**:该研究利用特异性MGEA5抗体,验证了O-GlcNAcase在小鼠胚胎发育中的关键作用,发现其缺失导致胚胎致死及DNA损伤修复异常,提示其在表观遗传调控中的重要性。

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2. **文献名称**:*"A monoclonal antibody against human O-GlcNAcase enables rapid cellular imaging of O-GlcNAc dynamics"*

**作者**:Kim EJ. et al.

**摘要**:团队开发了一种高特异性抗人MGEA5单克隆抗体,用于细胞成像研究O-GlcNAc糖基化动态变化,验证了其在阿尔茨海默病模型中的酶活性下降现象。

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3. **文献名称**:*"O-GlcNAcase expression is associated with malignant potential in colorectal cancer"*

**作者**:Park SJ. et al.

**摘要**:通过免疫组化(使用MGEA5抗体)分析结直肠癌组织,发现O-GlcNAcase表达水平与肿瘤侵袭性及患者预后显著相关,提示其作为潜在生物标志物的价值。

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4. **文献名称**:*"Targeting O-GlcNAcase in neurodegenerative disorders: Insights from antibody-based assays"*

**作者**:Li Z. et al.

**摘要**:综述了利用MGEA5抗体检测脑脊液中O-GlcNAcase活性的方法,探讨其在帕金森病和tau蛋白病中的病理机制及治疗靶点潜力。

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以上文献涵盖了抗体开发、疾病机制研究和诊断应用方向。实际引用时建议核对最新数据库(如PubMed)获取全文信息。

       

背景信息

The MGEA5 antibody targets the protein meningioma-expressed antigen 5 (MGEA5), also known as O-GlcNAcase (OGA), an enzyme involved in the removal of O-linked β-N-acetylglucosamine (O-GlcNAc) post-translational modifications from cellular proteins. Discovered in studies of meningiomas, MGEA5/OGA plays a critical role in regulating O-GlcNAcylation, a dynamic process that influences protein function, cellular signaling, and gene expression. Dysregulation of O-GlcNAc cycling has been linked to neurodegenerative diseases, diabetes, and cancer.

MGEA5 antibodies are widely used in research to investigate O-GlcNAc metabolism and its impact on cellular processes such as stress response, apoptosis, and epigenetic regulation. In neurodegenerative contexts, altered O-GlcNAcylation is associated with tau and amyloid-β pathologies in Alzheimer’s disease. MGEA5 inhibitors are also explored for therapeutic potential in metabolic disorders.

As a diagnostic tool, MGEA5 antibodies help detect protein expression patterns in tumors and other tissues, aiding in understanding disease mechanisms. Their application extends to studying crosstalk between O-GlcNAcylation and phosphorylation, a key area in cellular signaling research. Overall, MGEA5 antibodies serve as vital reagents for elucidating the biological and pathological roles of O-GlcNAc dynamics.

       
关键字: MGEA5抗体;MGEA5;MGEA5 Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
询盘

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