KIFAP3抗体;KIFAP3 Antibody—艾普蒂

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     Western blot analysis of KIFAP3 expression in HeLa cell lysate.    

  
  

The KIFAP3 antibody is a tool used to detect Kinesin-associated protein 3 (KIFAP3), a component of the kinesin-2 motor complex involved in intracellular transport. KIFAP3. also known as KAP3 or SMAP, binds to the kinesin-2 heterodimer (KIF3A/KIF3B) to form a tripartite complex critical for anterograde movement of cargoes, including organelles, vesicles, and proteins, along microtubules. This complex plays roles in ciliogenesis, neuronal axonal transport, and cell division. KIFAP3 acts as an adaptor, linking cargo molecules to the motor complex, and may regulate kinesin activity through conformational changes or post-translational modifications.

Antibodies targeting KIFAP3 are widely used in research to study its expression, localization, and interactions in normal and diseased states. They facilitate techniques like Western blotting, immunofluorescence, and co-immunoprecipitation. Dysregulation of KIFAP3 has been implicated in cancers (e.g., breast, colorectal) and neurodegenerative disorders, where disrupted intracellular transport contributes to pathogenesis. Some studies suggest KIFAP3 overexpression correlates with tumor progression, while others highlight its potential as a therapeutic target. Commercial KIFAP3 antibodies are typically raised in rabbits or mice, with validation in specific applications. However, users must verify cross-reactivity and specificity due to protein isoforms and homology within kinesin family members. Ongoing research continues to explore its functional diversity and clinical relevance.