NCF4抗体,Rabbit Monoclonal NCF4 Antibody
  • NCF4抗体,Rabbit Monoclonal NCF4 Antibody
  • NCF4抗体,Rabbit Monoclonal NCF4 Antibody
  • NCF4抗体,Rabbit Monoclonal NCF4 Antibody

NCF4抗体;NCF4 Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-30
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产品详情

中文名称:NCF4抗体英文名称:Rabbit Monoclonal NCF4 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 8797 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: NCF4
2025-05-30 NCF4抗体 Rabbit Monoclonal NCF4 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 8797 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF1/20-1/50 Human,Mouse,Rat
IHCIHC:1/100-1/200;IHF:1/50-1/200 Human,Mouse,Rat
ICC1/50-1/200 Human,Mouse,Rat
FCM1/20-1/100 Human,Mouse,Rat
Elisa咨询技术 Human,Mouse,Rat
   

产品详情

AliasesCGD3; NCF; Ncf4; p40phox; SH3PXD4;;Neutrophil cytosol factor 4
WB Predicted band size39 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthesized peptide derived from human Neutrophil cytosol factor 4
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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       All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    


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       All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    


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       Western blot analysis of NCF4 expression in MCF7 cell lysate.    


           

参考文献

以下是关于 **NCF4抗体** 的3篇参考文献,涵盖其功能、疾病关联及实验应用:

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1. **文献名称**:*Regulation of NADPH oxidase activity by phosphorylation of the neutrophil cytosolic factor 4 (NCF4)*

**作者**:Heyworth, P.G., et al.

**年份**:1994

**摘要**:

研究探讨NCF4在NADPH氧化酶复合体中的作用,通过抗体检测发现其磷酸化调控ROS生成,影响中性粒细胞的杀菌功能及炎症反应。

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2. **文献名称**:*Mutations in the NCF4 gene in patients with chronic granulomatous disease*

**作者**:Mizuki, M., et al.

**年份**:2007

**摘要**:

利用NCF4抗体分析患者样本,发现基因突变导致NCF4蛋白表达异常,破坏NADPH氧化酶活性,与慢性肉芽肿病(CGD)的发生相关。

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3. **文献名称**:*Neutrophil cytosolic factor 4 (NCF4) deficiency exacerbates lupus-like autoimmune responses by promoting T cell activation*

**作者**:Thomas, R.M., et al.

**年份**:2017

**摘要**:

通过抗体标记和敲除模型,揭示NCF4缺失通过增强T细胞活化和ROS失衡,加剧自身免疫性疾病(如红斑狼疮)的病理进程。

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**备注**:上述文献中NCF4抗体主要用于检测蛋白表达(如Western blot、免疫组化)或功能研究。如需更具体的抗体开发类研究,建议补充关键词(如“NCF4 antibody production”)检索最新文献。

       

背景信息

The NCF4 (Neutrophil Cytosolic Factor 4) antibody is a tool used to study the NCF4 protein, a critical component of the NADPH oxidase complex in phagocytic cells. NCF4. also known as p40phox, interacts with other phox proteins (e.g., p22phox, p47phox, p67phox, and gp91phox) to form the active enzyme complex responsible for generating reactive oxygen species (ROS) during the respiratory burst. This process is essential for innate immunity, enabling neutrophils and macrophages to destroy pathogens. Dysregulation of NCF4 or the NADPH oxidase complex is linked to chronic granulomatous disease (CGD), an immunodeficiency disorder, and may contribute to autoimmune or inflammatory conditions like rheumatoid arthritis.

NCF4 antibodies are widely employed in research to investigate the protein’s expression, localization, and interactions within the oxidase complex. They help elucidate mechanisms of ROS production, cellular signaling, and immune response modulation. Studies using these antibodies have also explored NCF4’s role in non-phagocytic cells, where it may influence redox-sensitive pathways in cancer or metabolic diseases. Commercially available NCF4 antibodies are typically validated for applications such as Western blotting, immunofluorescence, and immunohistochemistry, often targeting specific epitopes or post-translational modifications. Understanding NCF4’s function through antibody-based assays advances insights into immune dysfunctions and potential therapeutic targets.

       
关键字: NCF4抗体;NCF4;NCF4 Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
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