Phospho-TAOK1/2/3(S181+S181+S177)抗体;Phospho-TAOK1/2/3(S181+S181+S177) Antibody—艾普蒂 新品

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     Western blot analysis of Phospho-TAOK1/2/3 (S181 + S181 + S177) expression in (1) 293 cell lysate; (2) 293 cell treated with Lambda Phosphatase lysate.    

  
  

Phospho-TAOK1/2/3(S181+S181+S177) antibodies specifically detect the phosphorylated forms of TAO kinase isoforms 1. 2. and 3 at conserved serine residues (S181 in TAOK1/2 and S177 in TAOK3). These kinases belong to the STE20 family of serine/threonine kinases and play critical roles in regulating diverse cellular processes, including mitogen-activated protein kinase (MAPK) signaling, cytoskeletal reorganization, apoptosis, and cell cycle progression. Phosphorylation at these sites is associated with kinase activation, often triggered by cellular stress, DNA damage, or other stimuli that modulate TAOK activity.

TAOK1. TAOK2. and TAOK3 share structural homology but exhibit tissue-specific expression and functional divergence. TAOK1 is widely expressed and implicated in neuronal development, TAOK2 is enriched in testes and linked to cell polarity, while TAOK3 regulates immune responses and hematopoiesis. The phosphorylation status of these residues serves as a biomarker for their activation state, enabling researchers to study their involvement in signaling pathways.

These antibodies are essential tools for investigating TAOK-mediated signaling in disease models, such as cancer, neurodegenerative disorders, and immune dysregulation. Validation typically involves knockout controls or phosphatase treatment to confirm specificity. Cross-reactivity between isoforms should be considered due to sequence similarity. Applications include Western blotting, immunofluorescence, and immunoprecipitation to assess spatial-temporal activation patterns under physiological or pathological conditions.