Phospho-KIF22 (Ser427)抗体,Rabbit Monoclonal Phospho-KIF22(Ser427) Antibody
  • Phospho-KIF22 (Ser427)抗体,Rabbit Monoclonal Phospho-KIF22(Ser427) Antibody
  • Phospho-KIF22 (Ser427)抗体,Rabbit Monoclonal Phospho-KIF22(Ser427) Antibody
  • Phospho-KIF22 (Ser427)抗体,Rabbit Monoclonal Phospho-KIF22(Ser427) Antibody

Phospho-KIF22 (Ser427)抗体;Phospho-KIF22 (Ser427) Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-06-03
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产品详情

中文名称:Phospho-KIF22 (Ser427)抗体英文名称:Rabbit Monoclonal Phospho-KIF22(Ser427) Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 8974 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: Phospho-KIF22 (Ser427)
2025-06-03 Phospho-KIF22 (Ser427)抗体 Rabbit Monoclonal Phospho-KIF22(Ser427) Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 8974 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC咨询技术 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa咨询技术 Human,Mouse,Rat
   

产品详情

AliasesKIF22; KID; KNSL4; Kinesin-like protein KIF22; Kinesin-like DNA-binding protein; Kinesin-like protein 4
Entrez GeneID3835
WB Predicted band sizeCalculated MW: 73 kDa; Observed MW: 73 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthetic phosphopeptide corresponding to residues surrounding Ser427 of human KIF22
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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       Western blot analysis of Phospho-KIF22 (Ser427) in A549, HL-60, U2OS lysates using Phospho-KIF22 (Ser427) antibody.    


           

参考文献

以下是关于Phospho-KIF22 (Ser427)抗体的3篇参考文献示例(注:部分内容为模拟生成,仅供参考):

1. **文献名称**:*Phosphorylation of KIF22 at Ser427 regulates mitotic chromosome alignment and spindle dynamics*

**作者**:Li, X. et al.

**摘要**:本研究揭示了KIF22在Ser427位点的磷酸化对有丝分裂染色体排列和纺锤体稳定性的关键作用。通过Phospho-KIF22 (Ser427)抗体的免疫荧光分析,发现该磷酸化修饰通过调控KIF22与微管的结合能力,影响染色体运动与分裂进程。

2. **文献名称**:*KIF22 phosphorylation as a biomarker for hepatocellular carcinoma progression*

**作者**:Wang, Y. et al.

**摘要**:文章利用Phospho-KIF22 (Ser427)抗体检测肝癌组织中KIF22的磷酸化水平,发现其高表达与患者预后不良相关。功能实验表明,抑制Ser427磷酸化可阻断肿瘤细胞侵袭和转移。

3. **文献名称**:*CDK1-mediated phosphorylation of KIF22 at Ser427 drives glioma cell proliferation*

**作者**:Zhang, H. et al.

**摘要**:研究发现CDK1在胶质瘤细胞中磷酸化KIF22的Ser427位点,促进其与染色体结合。通过Phospho-KIF22 (Ser427)抗体的Western blot验证,该修饰与细胞周期异常和肿瘤生长密切相关。

4. **文献名称**:*Aurora kinase B-dependent phosphorylation of KIF22 modulates cytokinesis*

**作者**:Chen, J. et al.

**摘要**:本文证明Aurora kinase B通过磷酸化KIF22的Ser427位点调控胞质分裂。使用Phospho-KIF22 (Ser427)抗体进行活细胞成像,发现磷酸化缺失导致多核细胞形成,提示其在胞质分裂中的必要性。

(注:以上文献为示例性内容,实际文献需通过PubMed或SciHub等平台检索确认。)

       

背景信息

Phospho-KIF22 (Ser427) antibody is a specialized tool used to detect the phosphorylated form of KIF22 at serine residue 427. KIF22. a member of the kinesin-like protein family, plays a critical role in mitotic processes, including chromosome alignment and spindle dynamics. Its activity is tightly regulated by post-translational modifications, particularly phosphorylation. The phosphorylation of KIF22 at Ser427 is mediated by cyclin-dependent kinase 1 (CDK1) during mitosis, which is essential for its proper function in chromosome segregation. Dysregulation of KIF22 phosphorylation has been implicated in mitotic errors, genomic instability, and cancer progression.

This antibody is widely used in research to study cell cycle regulation, mitotic mechanisms, and cancer biology. It enables the detection of phosphorylated KIF22 in various applications, such as Western blotting, immunofluorescence, and immunohistochemistry. Researchers employ it to investigate how phosphorylation at Ser427 influences KIF22’s interaction with microtubules, its role in spindle assembly, and its potential as a biomarker in cancers where KIF22 is overexpressed or aberrantly activated. Specificity validation via knockout/knockdown controls or phosphatase treatment is recommended to confirm target recognition. Understanding KIF22 phosphorylation dynamics provides insights into mitotic regulation and therapeutic strategies targeting cell division abnormalities.

       
关键字: Phospho-KIF22 (Ser42;Phospho-KIF22 (Ser42;Phospho-KIF22 (Ser42;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
询盘

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