Phospho-Hormone Sensitive Lipase (Ser855)抗体,Rabbit Monoclonal Phospho-HormoneSensitiveLipase(Ser855) Antibody
  • Phospho-Hormone Sensitive Lipase (Ser855)抗体,Rabbit Monoclonal Phospho-HormoneSensitiveLipase(Ser855) Antibody
  • Phospho-Hormone Sensitive Lipase (Ser855)抗体,Rabbit Monoclonal Phospho-HormoneSensitiveLipase(Ser855) Antibody
  • Phospho-Hormone Sensitive Lipase (Ser855)抗体,Rabbit Monoclonal Phospho-HormoneSensitiveLipase(Ser855) Antibody

Phospho-Hormone Sensitive Lipase (Ser855)抗体;Phospho-Hormone Sensitive Lipase (Ser855) Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-06-03
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产品详情

中文名称:Phospho-Hormone Sensitive Lipase (Ser855)抗体英文名称:Rabbit Monoclonal Phospho-HormoneSensitiveLipase(Ser855) Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 8993 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: Phospho-Hormone Sensitive Lipase (Ser855)
2025-06-03 Phospho-Hormone Sensitive Lipase (Ser855)抗体 Rabbit Monoclonal Phospho-HormoneSensitiveLipase(Ser855) Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 8993 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC咨询技术 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa咨询技术 Human,Mouse,Rat
   

产品详情

AliasesLIPE; Hormone-sensitive lipase; HSL
Entrez GeneID3991
WB Predicted band sizeCalculated MW: 117 kDa; Observed MW: 83 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthetic phosphopeptide corresponding to residues surrounding Ser855 of human Hormone sensitive lipase/HSL
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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       Western blot analysis of Hormone sensitive lipase/HSL (Phospho-Ser855) in A549, HL-60, U2OS lysates using Phospho-Hormone Sensitive Lipase (Ser855) antibody.    


           

参考文献

以下是关于Phospho-Hormone Sensitive Lipase (Ser855)抗体的示例参考文献(部分为假设性示例,仅供参考):

1. **文献名称**:*Regulation of Hormone-Sensitive Lipase by Phosphorylation at Ser855 in Adipocytes*

**作者**:Smith A, et al.

**摘要**:本研究阐明了Ser855位点的磷酸化在激素敏感脂肪酶(HSL)活性调控中的作用,通过体外实验证明该位点的磷酸化可增强脂肪分解,并开发了特异性识别Ser855磷酸化的抗体用于Western blot分析。

2. **文献名称**:*Role of PKA in Activating HSL via Ser855 Phosphorylation During Exercise*

**作者**:Brown K, et al.

**摘要**:通过使用Phospho-HSL (Ser855)抗体,研究发现运动诱导的cAMP-PKA信号通路直接磷酸化HSL Ser855位点,促进脂肪组织中的甘油三酯水解,为能量代谢提供底物。

3. **文献名称**:*Phospho-Ser855 HSL Antibody in Obesity Research: Validation and Application*

**作者**:Zhang L, et al.

**摘要**:本文验证了Phospho-HSL (Ser855)抗体的特异性,并应用于肥胖小鼠模型,发现高脂饮食显著降低Ser855磷酸化水平,提示胰岛素抵抗与HSL活性受损相关。

4. **文献名称**:*Cross-Species Reactivity of Phospho-HSL (Ser855) Antibody in Metabolic Studies*

**作者**:Johnson R, et al.

**摘要**:该研究评估了Ser855磷酸化抗体在小鼠、大鼠和人类样本中的交叉反应性,证明其在多物种模型中可用于检测HSL活性变化,支持其在代谢疾病研究中的广泛应用。

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**注**:以上文献为示例性内容,实际引用时请通过PubMed、Web of Science等平台检索真实文献。

       

背景信息

Phospho-Hormone Sensitive Lipase (Ser855) antibody is a specialized tool used to detect the activated form of Hormone-Sensitive Lipase (HSL), a key enzyme regulating lipid metabolism. HSL plays a central role in hydrolyzing stored triglycerides in adipose tissue and cholesterol esters in steroidogenic tissues, releasing free fatty acids and cholesterol for energy production or hormone synthesis. Its activity is tightly controlled by phosphorylation at specific serine residues, including Ser855. which is part of a regulatory mechanism mediated by hormonal signals such as catecholamines (via β-adrenergic receptors) and insulin.

Phosphorylation at Ser855. located in the N-terminal regulatory domain of HSL, is associated with enzyme activation and translocation to lipid droplets. This post-translational modification is primarily triggered by cyclic AMP (cAMP)-dependent protein kinase A (PKA) signaling, which responds to fasting, stress, or exercise. The Phospho-HSL (Ser855) antibody specifically recognizes this phosphorylation event, enabling researchers to study dynamic changes in HSL activation under various physiological or pathological conditions, such as obesity, diabetes, or metabolic syndrome. It is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to explore tissue-specific lipolytic regulation and hormonal crosstalk. Validating antibody specificity through knockout controls or phosphorylation-blocking assays is critical for accurate interpretation of results.

       
关键字: Phospho-Hormone Sens;Phospho-Hormone Sens;Phospho-Hormone Sens;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
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  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
询盘

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