Phospho-JAK1 (Tyr1022)抗体;Phospho-JAK1 (Tyr1022) Antibody—艾普蒂 新品

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     Western blot analysis of Phospho-JAK1 (Tyr1022) in various lysates using Phospho-JAK1 (Tyr1022) antibody.    

  
  

The Phospho-JAK1 (Tyr1022) antibody is a critical tool for studying the activation status of Janus kinase 1 (JAK1), a tyrosine kinase involved in cytokine and growth factor signaling. JAK1 is a member of the JAK family (JAK1-3. TYK2) and plays a central role in the JAK-STAT signaling pathway. Upon ligand binding to cell surface receptors, JAK1 undergoes autophosphorylation or transphosphorylation at specific tyrosine residues, including Tyr1022. located in the activation loop of its kinase domain. This phosphorylation event is essential for JAK1 enzymatic activity, enabling downstream recruitment and phosphorylation of STAT transcription factors, which regulate immune responses, cell proliferation, and differentiation.

The Phospho-JAK1 (Tyr1022) antibody specifically detects JAK1 when phosphorylated at Tyr1022. serving as a marker for pathway activation. Dysregulation of JAK1 signaling is implicated in autoimmune diseases (e.g., rheumatoid arthritis), inflammatory disorders, and cancers, making this antibody valuable for both basic research and clinical studies. Applications include Western blotting, immunofluorescence, and immunohistochemistry to assess JAK1 activation in cell lines, tissues, or disease models. Researchers also use it to evaluate the efficacy of JAK inhibitors or to study signaling crosstalk in immune or cancer biology. Proper controls (e.g., phosphorylation-blocking agents, knockout cells) are recommended to confirm antibody specificity due to potential cross-reactivity with homologous phosphorylation sites in related kinases.