Aquaporin 2抗体;Aquaporin 2 Antibody—艾普蒂 新品

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     Western blot analysis of Aquaporin 2 in Raoms, Raji lysates using Aquaporin 2 antibody.    

  
  

Aquaporin 2 (AQP2) is a water channel protein primarily expressed in the principal cells of the renal collecting ducts, where it plays a critical role in regulating water reabsorption and maintaining body fluid homeostasis. Its activity is tightly controlled by the antidiuretic hormone vasopressin (AVP), which triggers AQP2 trafficking to the apical membrane, enabling water permeability and urine concentration. Dysregulation of AQP2 is implicated in disorders of water balance, such as nephrogenic diabetes insipidus (NDI), where genetic mutations or acquired defects impair AQP2 function, leading to excessive urine output and dehydration.

AQP2 antibodies are essential tools for studying the expression, localization, and function of this protein in both physiological and pathological contexts. They are widely used in techniques like immunohistochemistry, Western blotting, and immunofluorescence to assess AQP2 levels in kidney tissues or cell models. In research, these antibodies help elucidate mechanisms underlying AVP signaling, AQP2 phosphorylation, and membrane recycling. Clinically, they aid in diagnosing NDI by detecting reduced or aberrant AQP2 expression in renal biopsies or urinary exosomes. Additionally, AQP2 antibodies contribute to investigating conditions like heart failure, cirrhosis, or syndrome of inappropriate antidiuretic hormone (SIADH), where dysregulated AQP2 contributes to water retention. Their specificity and reliability make them indispensable for advancing understanding of renal physiology and developing targeted therapies for water balance disorders.