Product Name：Zilucoplan
CAS No.：1841136-73-9
Synonyms：抑制剂多肽Zilucoplan
Catalog No.：220P174
Brand：Typeptide Biotech（肽研生物）
Description：Zilucoplan是一种15个氨基酸的大环肽，同时也是有效的补体成分 5 (C5) 抑制剂多肽，能特异性的靶向末端补体激活途径的组分C5，从而防止C5被C5转化酶裂解为补体成分C5a和C5b，进而阻止膜攻击复合物（MAC）的下游组装和活性。Zilucoplan可用于免疫介导的坏死性肌病 (IMNM) 以及全身性重症肌无力（gMG）的相关研究。
Zilucoplan is a 15 amino acid macrocyclic peptide and an effective complement component 5 (C5) inhibitor polypeptide. It can specifically target the component C5 of the terminal complement activation pathway, thereby preventing C5 from being cleaved by C5 convertase into complement components C5a and C5b, and thus preventing downstream assembly and activity of membrane attack complexes (MACs). Zilucoplan can be used for research on immune-mediated necrotizing myopathy (IMNM) and systemic myasthenia gravis (gMG).
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | Ac-KVERFD-{N-Me-Asp}-Tle-Y-{3-(1H-PYRROLO(2,3-B)PYRIDIN-3-YL)-L-ALANYL}-EYP-Cha-Lys（C16-β-Asp-Peg24）(Chemical Bridge Lys1-Asp6) |
Sequence(3-letter code) | Ac-Lys-Val-Glu-Arg-Phe-Asp-{N-Me-Asp}-Tle-Tyr-{3-(1H-PYRROLO(2,3-B)PYRIDIN-3-YL)-L-ALANYL}-Glu-Tyr-Pro-Cha-Lys（C16-β-Asp-Peg24）(Chemical Bridge Lys1-Asp6) |
Peptide Structure | 
|
Molecular Formula | C172H278N24O55 |
Molecular Weight | 3562.18 |
订购联系方式：
南京肽研生物生物科技有限公司
手机号：19961912513(微信同号)
QQ: 2178255659
邮箱：sales@typeptide.com
联系人：顾经理
申明：本产品仅供科研使用，不得用于人体。
关键字： Zilucoplan;抑制剂多肽Zilucoplan;1841136-73-9;多肽;多肽合成;
肽研生物坐落于国家级新区南京江北新区新材料产业园，是一家专业从事多肽产 品的研发、生产和销售以及多肽技术转让的高新技术企业。公司秉持“诚信、严 谨、务实”的匠人精神，持续投入研发，不断创新，致力于为科研工作者提供丰 富全面的多肽修饰类型和优质的产品。