Product Name:Peptide P60
CAS No.:1319725-20-6
Synonyms:FOXP3抑制剂多肽
Catalog No.:220P058
Brand:Typeptide Biotech(肽研生物)
Description:Peptide P60是一种FOXP3抑制剂多肽,是由15氨基酸组成的多肽。Peptide P60 能够进入细胞,抑制 FOXP3 的核转位,并降低其抑制转录因子 NF-κB 和 NFAT 的能力。Peptide P60 能够抑制小鼠和人类来源的调节性 T 细胞 (Treg) 的免疫抑制活性,并在体外增强效应 T 细胞的刺激。Peptide P60 可诱发一种淋巴增生性自身免疫综合征,其病理表现与报道的缺乏功能性 Foxp3 的斑驳鼠相似。Peptide P60 可以提高癌症和病毒疫苗的免疫原性。
Peptide P60 is a FOXP3 inhibitor peptide composed of 15 amino acids. Peptide P60 can enter cells, inhibit the nuclear translocation of FOXP3, and reduce its ability to inhibit transcription factors NF - κ B and NFAT. Peptide P60 can inhibit the immunosuppressive activity of regulatory T cells (Tregs) derived from mice and humans, and enhance the stimulation of effector T cells in vitro. Peptide P60 can induce a lymphoproliferative autoimmune syndrome, whose pathological manifestations are similar to those reported in mottled mice lacking functional Foxp3. Peptide P60 can enhance the immunogenicity of cancer and viral vaccines.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility:H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | RDFQSFRKMWPFFAM |
Sequence(3-letter code) | H-Arg-Asp-Phe-Gln-Ser-Phe-Arg-Lys-Met-Trp-Pro-Phe-Phe-Ala-Met-OH |
Peptide Structure | 
|
Molecular Formula | C95H132N24O20S2 |
Molecular Weight | 1994.34 |
订购联系方式:
南京肽研生物生物科技有限公司
手机号:19961912513(微信同号)
QQ: 2178255659
邮箱:sales@typeptide.com
联系人:顾经理
申明:本产品仅供科研使用,不得用于人体。
关键字: Peptide P60;FOXP3抑制剂多肽;1319725-20-6;多肽;多肽合成;
肽研生物坐落于国家级新区南京江北新区新材料产业园,是一家专业从事多肽产 品的研发、生产和销售以及多肽技术转让的高新技术企业。公司秉持“诚信、严 谨、务实”的匠人精神,持续投入研发,不断创新,致力于为科研工作者提供丰 富全面的多肽修饰类型和优质的产品。