产品概述
Caveolin-1 Rabbit Monoclonal antibody
Rabbit Monoclonal antibody
Rabbit
WB,IHC,IF,IP,ELISA
Human,Mouse,Rat,
产品性能
Unconjugated
Unmodified
IgG,Kappa
Monoclonal
Liquid
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Protein A
免疫原
CAV1
CAV1;CAV;Caveolin-1
857
Q03135
产品应用
IHC 1:1000-1:4000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
Calculated MW:20kD;Observed MW:20kD
研究背景
Cell localization:Membrane.The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.[provided by RefSeq, Mar 2010],
研究领域
武汉恩玑生命科技有限公司
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