Human CEACAM-6 / CD66c Protein, His Tag
分子别名(Synonym)
CEACAM6,CD66c,CEAL,NCA
表达区间及表达系统(Source)
Human CEACAM-6, His Tag (CE6-H5223) is expressed from human 293 cells (HEK293). It contains AA Lys 35 - Gly 320 (Accession # NP_002474.3).
Predicted N-terminus: Lys 35
蛋白结构(Molecular Characterization)

This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 32.0 kDa. The protein migrates as 45-65 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
内毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method / rFC method.
纯度(Purity)
>95% as determined by SDS-PAGE.
制剂(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重构方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存储(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.


背景介绍
癌胚抗原相关细胞黏附分子6(非特异性交叉反应抗原)(CEACAM6)亦称为CD66c、CEAL或NCA,是免疫球蛋白超家族中七个人类CEACAM成员之一。人类CEACAMs包括I型跨膜蛋白(CEACAM1、CEACAM3和CEACAM4)及GPI锚定蛋白(CEACAM5至CEACAM8),其中不存在CEACAM2。CEACAM6包含一个N端V型免疫球蛋白样结构域(N域)及两个C2型免疫球蛋白样结构域。该蛋白具有显著糖基化修饰,包括可介导与E-选择素、半乳糖凝集素及某些细菌菌毛结合的(唾液酸)LewisX表位。CEACAM6在粒细胞及其祖细胞中表达,同时存在于多器官上皮组织,并在胰腺癌、结肠腺癌及增生性息肉中呈现高表达。CEACAM6的过表达会赋予肿瘤细胞对黏附相关凋亡的抗性。
关键字: CEACAM-6;CEACAM-6蛋白;CEACAM-6重组蛋白;ACRO;百普赛斯;
百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球,横跨亚洲、北美洲、欧洲,在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家,与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。