Product Name：Cyclic(YCDGFYACYMDV)
CAS No.：535959-77-4
Synonyms：信号传导抑制剂多肽Cyclic(YCDGFYACYMDV)
Catalog No.：220P309
Brand：Typeptide Biotech（肽研生物）
Description：Cyclic(YCDGFYACYMDV)是一种 HER2 信号传导抑制剂多肽，是由12个氨基酸组成的多肽，具有抗癌活性。Cyclic(YCDGFYACYMDV) 在水溶液中自组装成纳米颗粒，通过与癌细胞上的 HER2 靶向结合转化为纳米原纤维，来破坏 HER2 二聚化和随后的下游信号事件，从而导致癌细胞凋亡 (Apoptosis)。这种对 HER2 乳腺癌的抑制作用在小鼠异种移植模型中被证明有效。
Cyclic(YCDGFYACYMDV) is a HER2 signaling inhibitor peptide composed of 12 amino acids, exhibiting anticancer activity. In aqueous solution, Cyclic(YCDGFYACYMDV) self-assembles into nanoparticles, which target and bind to HER2 on cancer cells, transforming into nanofibrils. This disrupts HER2 dimerization and subsequent downstream signaling events, ultimately inducing apoptosis (programmed cell death) in cancer cells. This HER2 breast cancer inhibitory effect has been validated in mouse xenograft models.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | YCDGFYACYMDV(Disulfide bridge: Cys2-Cys8) |
Sequence(3-letter code) | H-Tyr-Cys-Asp-Gly-Phe-Tyr-Ala-Cys-Tyr-Met-Asp-Val-OH(Disulfide bridge: Cys2-Cys8) |
Peptide Structure | 
|
Molecular Formula | C65H82N12O20S3 |
Molecular Weight | 1447.61 |
订购联系方式：
南京肽研生物生物科技有限公司
手机号：19961912513(微信同号)
QQ: 2178255659
邮箱：sales@typeptide.com
联系人：顾经理
申明：本产品仅供科研使用，不得用于人体。
关键字： Cyclic(YCDGFYACYMDV);535959-77-4;信号传导抑制剂多肽Cyclic(YCDG;多肽;多肽合成;
肽研生物坐落于国家级新区南京江北新区新材料产业园，是一家专业从事多肽产 品的研发、生产和销售以及多肽技术转让的高新技术企业。公司秉持“诚信、严 谨、务实”的匠人精神，持续投入研发，不断创新，致力于为科研工作者提供丰 富全面的多肽修饰类型和优质的产品。