货号:GS40034
Anzurstobart is an investigational, fully human IgG4 monoclonal antibody that targets Signal Regulatory Protein Alpha (SIRPα) with high affinity. It functions as a blocking antibody that specifically inhibits the interaction between SIRPα on macrophages and its ligand CD47 on tumor cells. By disrupting this “don't-eat-me” signaling axis, anzurstobart promotes macrophage-mediated phagocytosis of cancer cells. It is currently in clinical development (Phase I/II) for the treatment of various advanced solid tumors and hematologic malignancies, representing a novel strategy in cancer immunotherapy.
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