货号:GS40186
Divozilimab targets and binds to MS4A1 (membrane-spanning 4-domains subfamily A member 1, CD20), a B cell surface molecule with a role in the development and differentiation of B cells into plasma cells. Once bound to MS4A1, divozilimab depletes circulating CD20+ B cells by apoptosis. Divozilimab is an IgG1-kappa antibody able to induce complement-dependent cytotoxicity (CDC), antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP) to indirectly deplete CD20+ expressing cells.
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