货号:GS40349
Ivuxolimab is a humanized IgG2 monoclonal antibody agonist targeting OX40 (CD134). Its IgG2 isotype is selected to minimize antibody-dependent effector functions while maximizing the agonistic activity required to directly stimulate the OX40 receptor. By binding to OX40 on activated T cells, Ivuxolimab is designed to enhance T-cell proliferation, survival, and functional activity, thereby promoting a robust anti-tumor immune response. It has been developed and investigated as an immune stimulatory therapy for various advanced solid tumors.
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