(Leronlimab)Biosimilar Reference Antibody-GS40375

货号：GS40375

Leronlimab (also known as PRO 140) is a humanized IgG4 monoclonal antibody that functions as a CCR5 antagonist. It selectively binds to the CCR5 chemokine receptor on the surface of CD4+ T cells and other immune cells, blocking its interaction with natural ligands and, most critically, with the human immunodeficiency virus (HIV-1) envelope glycoprotein gp120. This blockade prevents the viral entry step that is dependent on the CCR5 co-receptor. It has been developed as a long-acting (weekly subcutaneous) antiretroviral therapy for CCR5-tropic HIV-1 infection, showing efficacy in treatment-experienced patients. It has also been investigated for other conditions where CCR5 plays a role, such as metastatic cancer and COVID-19, though clinical benefit in these areas remains unconfirmed.