(Lonigutamab)Biosimilar Reference Antibody-GS40401

货号：GS40401

Lonigutamab is a humanized monoclonal antibody that specifically targets the insulin-like growth factor 1 receptor (IGF-1R), a transmembrane receptor tyrosine kinase. By binding to IGF-1R, it blocks the binding of its ligands (IGF-1 and IGF-2), inhibiting downstream signaling pathways such as PI3K/AKT and MAPK/ERK. This blockade aims to suppress tumor cell proliferation, survival, and metastasis. It is being developed as a potential therapeutic agent for IGF-1R-dependent cancers, including certain solid tumors such as breast, lung, and colorectal cancer.