(Tilvestamab)Biosimilar Reference Antibody-GS40722

货号：GS40722

Tilvestamab (BGB149) is a humanized IgG1 kappa monoclonal antibody targeting AXL, a receptor tyrosine kinase involved in tumor growth, metastasis, and resistance to therapy. It binds to AXL to block its activation by ligand Gas6, inhibiting downstream signaling pathways (e.g., PI3K/AKT, MAPK) that promote cancer cell survival and immune evasion. It is being developed for the treatment of AXL-overexpressing solid tumors, such as lung, breast, and ovarian cancers.