Product Name：Cm-CATH2
CAS No.：N/A
Synonyms：抗菌肽Cm-CATH2
Catalog No.：220P342
Brand：Typeptide Biotech（肽研生物）
Description：Cm-CATH2 是一种从绿海龟中发现的抗菌肽，是由33个氨基酸组成的多肽。Cm-CATH2 通过快速破坏细菌细胞膜的完整性，具有强效、广谱且快速的杀菌能力，对革兰氏阳性菌 (如 VREF、金黄色葡萄球菌)、革兰氏阴性菌 (如大肠杆菌、肺炎克雷伯菌) 和真菌 (如白色念珠菌) 均表现出极强的活性，其 MIC 在 1.17-18.75 μg/mL的范围内。Cm-CATH2 对多种水生致病菌也有效。Cm-CATH2 不仅抑制生物膜形成，并且可以清除已形成的生物膜。Cm-CATH2 具有免疫调节功能和免疫细胞趋化作用，可抑制 LPS (HY-D1056) 刺激巨噬细胞产生的促炎细胞因子。Cm-CATH2 通过抑制 IκBα 的降解来阻止 NF-κB 的活化，同时抑制 MAPK 信号通路 (p38, JNK, ERK) 的磷酸化。Cm-CATH2 在小鼠腹膜炎模型和肺炎模型中均展示出强大的抗感染能力。
Cm-CATH2 is an antimicrobial peptide discovered in green sea turtles, composed of 33 amino acids. It exhibits potent, broad-spectrum, and rapid bactericidal activity by rapidly disrupting the integrity of bacterial cell membranes, demonstrating strong efficacy against Gram-positive bacteria (e.g., VREF, Staphylococcus aureus), Gram-negative bacteria (e.g., Escherichia coli, Klebsiella pneumoniae), and fungi (e.g., Candida albicans), with an MIC ranging from 1.17 to 18.75 μg/mL. Cm-CATH2 is also effective against various aquatic pathogens. Not only does it inhibit biofilm formation, but it can also remove established biofilms. Cm-CATH2 possesses immunomodulatory functions and immune cell chemotactic effects, suppressing pro-inflammatory cytokine production in macrophages stimulated by LPS (HY-D1056). By inhibiting the degradation of IκBα, Cm-CATH2 prevents NF-κB activation while simultaneously blocking the phosphorylation of the MAPK signaling pathway (p38, JNK, ERK). Cm-CATH2 demonstrates robust anti-infection capabilities in both mouse peritonitis and pneumonia models.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | RRSRFGRFFKKVRKQLGRVLRHSRITVGGRMRF |
Sequence(3-letter code) | H-Arg-Arg-Ser-Arg-Phe-Gly-Arg-Phe-Phe-Lys-Lys-Val-Arg-Lys-Gln-Leu-Gly-Arg-Val-Leu-Arg-His-Ser-Arg-Ile-Thr-Val-Gly-Gly-Arg-Met-Arg-Phe-OH |
Peptide Structure | 
|
Molecular Formula | C181H307N69O38S1 |
Molecular Weight | 4089.88 |
订购联系方式：
南京肽研生物生物科技有限公司
手机号：19961912513(微信同号)
QQ: 2178255659
邮箱：sales@typeptide.com
联系人：顾经理
申明：本产品仅供科研使用，不得用于人体。
关键字： Cm-CATH2;抗菌肽Cm-CATH2;抗菌肽;多肽;多肽合成;
肽研生物坐落于国家级新区南京江北新区新材料产业园，是一家专业从事多肽产 品的研发、生产和销售以及多肽技术转让的高新技术企业。公司秉持“诚信、严 谨、务实”的匠人精神，持续投入研发，不断创新，致力于为科研工作者提供丰 富全面的多肽修饰类型和优质的产品。