人高灵敏白细胞介素12p70(IL-12p70)ELISA试剂盒
货号:LM8K4932H
规格:48T/96T
种属:Human
范围:7.8-500pg/ml
灵敏度:4.6pg/ml
用途:For quantitative detection of IL-12 p70 in serum, plasma, tissue homogenates and otherbiological fluids.
存储:2-8°C
截止日期: see kit label
原理:Sandwich
注意:仅供研究使用。
Background
IL-12 (interleukin 12) was first described as natural killer stimulating factor in 1989. The heterodimericcytokine IL-12 consists of a 35-kd light chain (p35 or IL-12A) and 40-kd heavy chain (p40 or IL-12B). The geneencoding p35 is located on chromosome 3 in human beings and on chromosome 6 in mice. The p35 proteincontains 197 amino acids and has homology to other single-chain cytokines (eg, IL-6 and G-CSF). The IL-12p40 gene is on the human chromosome 5 in the same area as IL-3, IL-5, and GM-CSF, and the mice gene is onchromosome 11. P40 has homology to the extracellular domain of members of hematopoietic cytokinereceptor family (eg, IL-6Rα). IL-12 (interleukin 12) receptor, binding interleukin 12, is composed of twosubunits, IL-12RB1 (also known as CD212) and IL12RB2. These IL-12 functions depend on its IL-12 and IL-12receptor complex.
IL-12 (interleukin 12) is a heterodimeric pro-inflammatory cytokine that induces the production ofinterferon-γ (IFN-γ), favours the differentiation of T helper 1 (TH1) cells and forms a link between innateresistance and adaptive immunity.
Dendritic cells (DCs) and phagocytes produce IL-12 in response to pathogens during infection. Production ofIL-12 is dependent on differential mechanisms of regulation of expression of the genes encoding IL-12,patterns of Toll-like receptor (TLR) expression and cross-regulation between the different DC subsets,involving cytokines such as IL-10 and type I IFN.
本产品只适用于科研，不能用于临床诊断。严禁用于临床医疗及其他非科研用途！
关键字： IL-12p70;高灵敏白细胞介素12p70;IL-12p70试剂盒;人IL-12p70 ELISA试剂盒;
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