Product Name：vosoritide
CAS No.：1480724-61-5
Synonyms：伏索利肽Vosoritide acetate
Catalog No.：218P043
Brand：Typeptide Biotech（肽研生物）
Description：vosoritide是一个由39个氨基酸组成的环状多肽，vosoritide通过与一种称为纳尿肽受体B型（NPR-B）的受体（目标）结合而起作用，该受体可减少成纤维细胞生长因子受体3（FGFR3）的活性。FGFR3是一种受体，通常由一种称为酸性和基本成纤维细胞生长因子的蛋白质激活时，对软骨和骨骼生长进行调节。伏索利肽通过抑制软骨细胞的发育（细胞增殖和分化）来达到这一作用，软骨细胞是产生和维持软骨基质的细胞，这也是骨骼生长所必需的。患有腺细胞增多症的儿童有几种可能的FGFR3突变之一，导致这种受体的构成（永久）活性，导致软骨细胞活动整体减少，从而骨骼生长。
Vosoritide is a cyclic peptide composed of 39 amino acids. It functions by binding to a receptor known as natriuretic peptide receptor B (NPR-B), which reduces the activity of fibroblast growth factor receptor 3 (FGFR3). FGFR3 is a receptor typically activated by proteins called acidic and basic fibroblast growth factors, regulating the growth of cartilage and bone. Vosoritide achieves this effect by inhibiting the development (proliferation and differentiation) of chondrocytes, the cells responsible for producing and maintaining cartilage matrix, which is essential for bone growth. Children with achondroplasia may have one of several possible FGFR3 mutations, leading to constitutive (permanent) activation of this receptor, resulting in reduced overall chondrocyte activity and consequently impaired bone growth.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | PGQEHPNARKYKGANKKGLSKGCFGLKLDRIGSMSGLGC(Disulfide bridge:Cys23-Cys39) |
Sequence(3-letter code) | H-Pro-Gly-Gln-Glu-His-Pro-Asn-Ala-Arg-Lys-Tyr-Lys-Gly-Ala-Asn-Lys-Lys-Gly-Leu-Ser-Lys-Gly-Cys-Phe-Gly-Leu-Lys-Leu-Asp-Arg-Ile-Gly-Ser-Met-Ser-Gly-Leu-Gly-Cys-OH(Disulfide bridge:Cys23-Cys39) |
Peptide Structure | 
|
Molecular Formula | C176H290N56O51S3 |
Molecular Weight | 4102.77 |
订购联系方式：
南京肽研生物生物科技有限公司
手机号：19961912513(微信同号)
QQ: 2178255659
邮箱：sales@typeptide.com
联系人：顾经理
申明：本产品仅供科研使用，不得用于人体。
关键字： vosoritide;伏索利肽Vosoritide aceta;1480724-61-5;多肽;多肽合成;
肽研生物坐落于国家级新区南京江北新区新材料产业园，是一家专业从事多肽产 品的研发、生产和销售以及多肽技术转让的高新技术企业。公司秉持“诚信、严 谨、务实”的匠人精神，持续投入研发，不断创新，致力于为科研工作者提供丰 富全面的多肽修饰类型和优质的产品。