Product Name：Myelin Basic Protein (85-99) peptide antagonist
CAS No.：444305-16-2
Synonyms：免疫显性表位多肽
Catalog No.：176P06
Brand：Typeptide Biotech（肽研生物）
Description：Myelin Basic Protein (85-99) peptide antagonist是拮抗性多肽与 MBP (85-99) 竞争，MBP (85-99) 是髓鞘碱性蛋白 (MBP) 的免疫显性表位，是多发性硬化症 (MS) 中的主要候选自身抗原，与人类白细胞抗原 (HLA)-DR2 结合，是由15个氨基酸组成的多肽。该肽还抑制 MBP (85-99) 特异性 T 细胞克隆分泌 IL-2 并诱导脾细胞产生 Th2 细胞因子。 此外，可以证明该肽能够以与无规氨基酸共聚物（例如 Copaxone [poly (Y,E,A,K)n] 等随机氨基酸共聚物等效的方式）在几种模型中抑制实验性自身免疫性脑脊髓炎 (EAE) . 因此，这种合成肽可能适用于 MS 的研究。
The Myelin Basic Protein (85-99) peptide antagonist is a competitive peptide that binds to MBP (85-99), an immunodominant epitope of myelin basic protein (MBP) and a leading autoantigen in multiple sclerosis (MS). It binds to human leukocyte antigen (HLA)-DR2 and consists of a 15-amino-acid polypeptide. This peptide also inhibits IL-2 secretion by MBP (85-99)-specific T-cell clones and induces Th2 cytokine production in spleen cells. Additionally, it has been demonstrated to suppress experimental autoimmune encephalomyelitis (EAE) in several models in an equivalent manner to random amino acid copolymers (e.g., Copaxone [poly(Y,E,A,K)n]). Therefore, this synthetic peptide may be suitable for MS research.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | EKPKVEAYKAAAAPA |
Sequence(3-letter code) | H-Glu-Lys-Pro-Lys-Val-Glu-Ala-Tyr-Lys-Ala-Ala-Ala-Ala-Pro-Ala-OH |
Peptide Structure | 
|
Molecular Formula | C70H114N18O21 |
Molecular Weight | 1543.78 |
订购联系方式：
南京肽研生物生物科技有限公司
手机号：19961912513(微信同号)
QQ: 2178255659
邮箱：sales@typeptide.com
联系人：顾经理
申明：本产品仅供科研使用，不得用于人体。
关键字： 免疫显性表位多肽;Myelin Basic Protein;444305-16-2;多肽;多肽合成;
肽研生物坐落于国家级新区南京江北新区新材料产业园，是一家专业从事多肽产 品的研发、生产和销售以及多肽技术转让的高新技术企业。公司秉持“诚信、严 谨、务实”的匠人精神，持续投入研发，不断创新，致力于为科研工作者提供丰 富全面的多肽修饰类型和优质的产品。