PROTAC MDM2 Degrader-1 is a proteolysis-targeting chimera (PROTAC) designed to promote targeted degradation of mouse double minute 2 homolog (MDM2), an important negative regulator of the tumor suppressor protein p53. The chemical name of PROTAC MDM2 Degrader-1 is N,N'-(((oxybis(ethane-2,1-diyl))bis(oxy))bis(propane-3,1-diyl))bis(2-(4-((4R,5S)-4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)-2-oxopiperazin-1-yl)acetamide). By facilitating targeted protein degradation, the compound can promote MDM2 depletion through the ubiquitin–proteasome system, providing a research tool for investigating MDM2–p53 pathway regulation.
PROTAC MDM2 Degrader-1 has a CAS No. of 2249944-98-5, a molecular formula of C₇₄H₈₄Cl₄N₁₀O₁₃, and a molecular weight of 1463.33 g/mol. It is intended for research applications involving MDM2 degradation, p53 signaling, targeted protein degradation, PROTAC technology, cancer biology, apoptosis, and cell proliferation. The compound may be used to investigate MDM2-dependent cellular mechanisms and the biological consequences of modulating the MDM2–p53 signaling axis. For research use only.
关键字： PROTAC;MDM2 degrader;p53-MDM2 pathway;anticancer research;
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