Thalidomide-O-PEG4-amine hydrochloride is a synthetic E3 ligase ligand-linker conjugate containing a thalidomide-derived cereblon (CRBN) ligand and a PEG4 linker with a terminal amino group. The compound is designed as a building block for the synthesis of PROTAC (Proteolysis Targeting Chimera) molecules and other targeted protein degradation compounds.
The terminal amino group provides a reactive functional handle for further coupling with target-protein ligands or other linker components, while the thalidomide moiety enables recruitment of the CRBN E3 ubiquitin ligase. The PEG4 spacer can improve molecular flexibility and provide appropriate distance between the E3 ligase ligand and target-binding moiety.
Molecular Formula: C₂₃H₃₂ClN₃O₉
Molecular Weight: 529.97 g/mol
CAS No.: 2820929-03-9
Chemical Name: 4-((14-Amino-3,6,9,12-tetraoxatetradecyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride
Applications: PROTAC synthesis; CRBN-mediated targeted protein degradation; E3 ligase ligand-linker synthesis; medicinal chemistry; chemical biology research.
Product Type: E3 ligase ligand-linker conjugate / PROTAC building block.
关键字： PROTAC;E3 ligase ligand;Cereblon ligand;PEG linker;Cancer research;
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