Thalidomide-O-amido-PEG4-azide

Thalidomide-O-amido-PEG4-Azide is a thalidomide-based CRBN ligand containing a PEG4 linker and a terminal azide functional group. The thalidomide moiety enables recruitment of cereblon (CRBN), while the PEG4 spacer provides flexible distance between the CRBN-binding group and the terminal azide.

The terminal azide makes this compound suitable for click chemistry, particularly CuAAC reactions with alkyne-functionalized molecules. It can therefore serve as a versatile building block for the synthesis of PROTACs and other targeted protein-degradation molecules, where it can be conjugated to a target-binding ligand through an appropriate linker.

IUPAC Name: N-(14-azido-3,6,9,12-tetraoxatetradecyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide
Formula: C₂₅H₃₂N₆O₁₀
Molecular Weight: 576.6 g/mol