Pomalidomide-PEG4-Ph-NH2

Pomalidomide-PEG4-Ph-NH₂ is a pomalidomide-based CRBN ligand containing a PEG4 linker and a terminal phenylamine group. The pomalidomide moiety enables recruitment of cereblon (CRBN), while the PEG4 linker provides a flexible spacer between the CRBN-binding moiety and the terminal amine.

The primary amine (-NH₂) can be used for further chemical conjugation with carboxylic acids, activated esters, or other suitable functional groups. This compound can serve as a versatile PROTAC building block for the synthesis of cereblon-recruiting targeted protein degraders and other targeted protein degradation molecules.

IUPAC Name: 4-((2-(2-(2-(2-(4-aminophenoxy)ethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

Formula: C₂₇H₃₂N₄O₈
Molecular Weight: 540.6 g/mol