Pomalidomide-PEG4-Azide is a pomalidomide-based E3 ligase recruiting ligand featuring a PEG4 linker and a terminal azide (-N₃) functional group. The pomalidomide moiety binds to cereblon (CRBN), while the PEG4 linker provides a flexible spacer for connecting the E3 ligase ligand to a target-binding ligand.
The terminal azide serves as a versatile click chemistry handle, particularly for CuAAC (copper-catalyzed azide–alkyne cycloaddition) reactions with alkyne-functionalized compounds. This makes Pomalidomide-PEG4-Azide a useful PROTAC building block for the development of cereblon-recruiting targeted protein degraders.
IUPAC Name: 4-((14-azido-3,6,9,12-tetraoxatetradecyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dioneFormula: C₂₃H₃₀N₆O₈Molecular Weight: 518.5 g/mol
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