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抑制剂描述：
产品名称：SB-431542
产品别名：4-[4-(3,4-亚甲二氧基苯基)-5-(2-吡啶基)-1H-咪唑-2-基]-苯甲酰胺
英文别名：SB431542;SB 431542
靶点：ALK4；ALK7；ALK5
CAS：301836-41-9
纯度：>98%
外观：黄色至粉色固体
保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -80℃ for six months.
描述：
SB-431542 is a potent and selective inhibitor of ALK5 with IC50 of 94 nM, 100-fold more selective for ALK5 than p38 MAPK and other kinases.
溶解性：DMSO : 38.4 mg/mL(100 mM)
Ethanol : 3.8 mg/mL(10 mM)
体外研究：
SB-431542 inhibits TGF-beta1-induced fibronectin mRNA formation while displaying no measurable cytotoxicity in the 48 h XTT assay. SB-431542 (1 μM) significantly reduced the TGFβ–induced nuclear accumulation of Smad proteins. The IC50 for inhibiting TGFβ–induced nuclear fluorescence is approximately 50 nM. BMP-stimulated Smad1 nuclear fluorescence in MG63 cells was unaffected by SB-431542. the synergistic action of two inhibitors of SMAD signaling, Noggin and SB431542, is sufficient to induce rapid and complete neural conversion of >80% of hES cells under adherent culture conditions.
体内研究：SB-431542 augmented the capacity of bone marrow dendritic cells (BM-DCs) and human DCs to incorporate FITC-conjugated dextran. Intraperitoneal administration of SB-431542 initiated 3 and 7 days after the implantation of colon-26 cancer cells into the peritoneal cavity of BALB/c mice significantly induced CTL activity against colon-26. SB-431542 significantly inhibited lung metastasis from transplanted 4T1 mammary tumors in Balb/c mice.
产品信息订购：
abs810481
SB-431542
5mg
400
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