Product name
DNASE1 Polyclonal Antibody
Isotype
IgG
Form
Lyophilized or Liquid
Tested applications
WB,IF,ELISA,IHC
Species reactivity
Human,Mouse
Host Species
Rabbit
Purity
Affinity purification
Immunogen Information：
Immunogen
Recombinant protein of human DNASE1
Calculated molecular weight
19kDa/31kDa
Observed molecular weight
37kDa
Swiss Prot
P24855
Gene ID (NCBI)
1773
Alternative Names
DNL1;DRNI
Application Notes：
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB
1:500 - 1:2000
IF
1:50 - 1:100
IHC
1:50 - 1:500
Western blot analysis of extracts of various cell lines, using DNASE1 antibody.
Immunofluorescence analysis of HeLa cells using DNASE1 antibody.
Background：
This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
Storage：
Storage instructions
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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