Allyl glycidyl ether:Uses, Cancer Hazard and Toxicity

Allyl glycidyl ether is a colorless liquid with a strong, sweet odor. It is used in making resins, chlorinated compounds, and rubber.

Uses

Allyl glycidyl ether is a monoglycidyl derivative, used as a reactive epoxy diluent for epoxy resins, resin intermediate, stabilizer of chlorinated compounds, vinyl resins, and rubber.

In examining the methods to synthesize poly(allyl glycidyl ether), many of the approaches have relied on the utilization of a strong, non-nucleophilic base and removal of the conjugate acid (e.g., water, or tert-butanol) to generate an alkoxide initiator followed by the addition of allyl glycidyl ether (AGE) and polymerization at high temperatures (ca. 100 °C).9–12 A challenge with these strategies is that protic impurities are introduced during generation of the initiating system and these impurities may be difficult to quantitatively remove, leading to subsequent interference with the polymerization. Moreover, the use of high polymerization temperatures can be detrimental to the polymerization leading to unwanted side-reactions.

Toxicity

LD50 orally in Rabbit: 922 mg/kg LD50 dermal Rabbit 2550 mg/kg.

Cancer Hazard

There is limited evidence that Allyl glycidyl ether causes cancer in animals. It may cause cancer of the nose.

Allyl glycidyl ether may cause mutations (genetic changes).

Reproductive Hazard

Allyl glycidyl ether may damage the testes (male reproductive glands).