Chemical Safety Data Sheet MSDS / SDS
1,4-Dioxan-2-one
Revision Date:2026-03-20Revision Number:1
Product identifier
- Product name: 1,4-Dioxan-2-one
- CBnumber: CB1875232
- CAS: 3041-16-5
- EINECS Number: 608-477-2
- Synonyms: para-Dioxanone
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordWarning
P310 Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
Hazard statements
H318 Causes serious eye damage
Substance
- Product name: 1,4-Dioxan-2-one
- Synonyms: para-Dioxanone
- CAS: 3041-16-5
- EC number: 608-477-2
- MF: C4H6O3
- MW: 102.09
If inhaled
Remove person to fresh air and keep comfortable for breathing. Get medical advice/ attention if you feel unwell.
In case of skin contact
Take off all contaminated clothing immediately. Wash off with plenty of water. If skin irritation occurs: Get medical advice/ attention.
In case of eye contact
Rinse with plenty of water. If easy to do, remove contact lens, if worn. If eye irritation persists: Get medical advice/ attention.
If swallowed
Get medical advice/ attention. Rinse mouth.
Most important symptoms and effects, both acute and delayed
None known.
Suitable extinguishing media
Dry powder, Foam, Water spray, Carbon dioxide (CO2)
Specific hazards during fire fighting
No information available.
Specific extinguishing methods
Use extinguishing measures that are appropriate to local circumstances and the surrounding environment. Immediately evacuate personnel to safe areas. Remove undamaged containers from fire area if it is safe to do so.
Special protective equipment for fire-fighters
Use personal protective equipment.
NFPA 704
1
0
0
| HEALTH | 1 | Exposure would cause irritation with only minor residual injury (e.g. acetone, sodium bromate, potassium chloride) | |
| FIRE | 0 | Materials that will not burn under typical fire conditions, including intrinsically noncombustible materials such as concrete, stone, and sand. Materials that will not burn in air when exposed to a temperature of 820 °C (1,500 °F) for a period of 5 minutes.(e.g. Carbon tetrachloride) | |
| REACT | 0 | Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2) | |
| SPEC. HAZ. |
Personal precautions, protective equipment and emergency procedures
Wear suitable protective equipment. Keep people away from and upwind of spill/leak. Entry to non-involved personnel should be controlled around the leakage area by roping off, etc.
Environmental precautions
Prevent product from entering drains.
Methods and materials for containment and cleaning up
Pick up and arrange disposal without creating dust.
Handling
Technical measuresPrevent dispersion of dust.
Local/Total ventilation
Ensure adequate ventilation. Use a local exhaust ventilation.
Advice on safe handling
Avoid contact with skin, eyes and clothing. Wear personal protective equipment. Wash hands and face thoroughly after handling.
Avoidance of contact
Oxidizing agents
Storage
Conditions for safe storageKeep container tightly closed. Store in a refrigerator.
Ingredients with workplace control parameters
Contains no substances with occupational exposure limit values.
Engineering measures
Install a closed system or local exhaust.
Also install safety shower and eye bath.
Also install safety shower and eye bath.
Personal protective equipment
Respiratory protectionDust mask
Eye/face protection
Safety glasses
Face-shield
Skin and body protection
Face-shield
Protective suit
Hand protection
Protective gloves *Use personal protective equipment(PPE) approved under appropriate government standards and follow local and national regulations.
Information on basic physicochemical properties
- Physical stateSolid
- Density and/or relative density1.1717 (rough estimate)
- Other informationThe product is a liquid when ambient temperature is above melting point or due to supercooling.
- Molecular weight102.09 g/mol
- Viscosity, kinematicNo data available
- Viscosity, dynamicNo data available
- Decomposition temperatureNo data available
- Autoignition temperatureNo data available
- Partition coefficient: n-octanol/water-1.12
- Solubility in other solventsAcetonitrile (Slightly), Chloroform (Sparingly), Ethyl Acetate (Slightly)
- Water solubilityNo data available
- Solubility(ies)Acetonitrile (Slightly), Chloroform (Sparingly), Ethyl Acetate (Slightly)
- Vapor pressure11-19Pa at 20-25℃
- Lower explosion limit / Lower flammability limitNo data available
- Upper explosion limit / Upper flammability limitNo data available
- FlammabilityNo data available
- Evaporation rateNo data available
- Flash point86 °C (Calculated value)
- Boiling point/boiling range215 °C
- Melting point/freezing point28 °C
- pHNo data available
- Odor ThresholdNo data available
- OdorNo data available
- Colorwhite
- Appearancesolid
Reactivity
No data available
Chemical stability
Stable under normal conditions.
Possibility of hazardous reactions
None under normal processing.
Conditions to avoid
Heat.
Incompatible materials
Oxidizing agents
Hazardous decomposition products
Carbon monoxide, Carbon dioxide (CO2)
Acute toxicity
Components
1,4-Dioxan-2-one
Acute toxicity (other routes of administration)
LD50 (Rat): 790 mg/kg Application Route: Intraperitoneal injection
Skin corrosion/irritation
Product
Result
Skin irritation
Components
1,4-Dioxan-2-one
Result
Skin irritation
Serious eye damage/eye irritation
Product
Result
Eye irritation
Components
1,4-Dioxan-2-one
Result
Eye irritation
Respiratory or skin sensitization
Classified based on available data. For more details, see section 2.
Germ cell mutagenicity
Classified based on available data. For more details, see section 2.
Carcinogenicity
Classified based on available data. For more details, see section 2.
Reproductive toxicity
Classified based on available data. For more details, see section 2.
STOT-single exposure
Classified based on available data. For more details, see section 2.
STOT-repeated exposure
Classified based on available data. For more details, see section 2.
Repeated dose toxicity
Classified based on available data. For more details, see section 2.
Aspiration toxicity
Classified based on available data. For more details, see section 2.
RTECS No.
JH2290000 (1,4-Dioxan-2-one)
Ecotoxicity
No data available
Persistence and degradability
No data available
Bioaccumulative potential
Components:
1,4-Dioxan-2-one:
octanol/water
Partition coefficient: noctanol/water
-1.12
Mobility in soil
No data available
Other adverse effects
No data available
Disposal methods
Waste from residuesDisposal in accordance with local and national regulations. Entrust disposal to a licensed waste disposal company.
Contaminated packaging
Disposal in accordance with local and national regulations. Before disposal of used container, remove contents completely.
International Regulations
IATA-DGR
UN/ID No.Not applicable
Proper shipping name
Not applicable
Class
Not applicable
Subsidiary risk
Not applicable
Packing group
Not applicable
IMDG-Code
UN numberNot applicable
Proper shipping name
Not applicable
Class
Not applicable
Subsidiary risk
Not applicable
Packing group
Not applicable
EmS Code
Not applicable
Domestic regulation
GB 6944/12268
UN numberNot applicable
Proper shipping name
Not applicable
Class
Not applicable
Subsidiary risk
Not applicable
Packing group
Not applicable
Measures on the Environmental Administration of New Chemical Substances Registration
Registration/Notification numberB1A232215492
Downstream users need to comply with the conditions of safe use of the chemical, understand the environmental and health hazard and risk management measures identified on the SDS as well as the local/national regulations concerning the chemical.
Downstream users need to comply with the conditions of safe use of the chemical, understand the environmental and health hazard and risk management measures identified on the SDS as well as the local/national regulations concerning the chemical.
The ingredients of this product are reported in the following inventories
CH BAGREGNot in compliance with the inventory
TSCA
Substance(s) not listed on TSCA inventory
AICS
Not in compliance with the inventory
DSL
This product contains the following components that are not on the
Canadian DSL nor NDSL.
1,4-Dioxan-2-one
ENCS
Canadian DSL nor NDSL.
1,4-Dioxan-2-one
Not in compliance with the inventory
ISHL
On the inventory, or in compliance with the inventory
KECI
Not in compliance with the inventory
PICCS
Not in compliance with the inventory
IECSC
Not in compliance with the inventory
NZIoC
Not in compliance with the inventory
Abbreviations and acronyms
CAS: Chemical Abstracts Service
TWA: Time-Weighted Average
STEL: Short-Term Exposure Limit
LD50: Lethal Dose 50%
LC50: Lethal Concentration 50%
EC50: Effective Concentration 50%
PEL: Permissible Exposure Limit
TLV: Threshold Limit Value
IMDG: International Maritime Dangerous Goods Code
IATA: International Air Transport Association
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
DOT: US Department of Transportation
NFPA: National Fire Protection Association
NIOSH: National Institute for Occupational Safety and Health
OSHA: Occupational Safety and Health Administration
TWA: Time-Weighted Average
STEL: Short-Term Exposure Limit
LD50: Lethal Dose 50%
LC50: Lethal Concentration 50%
EC50: Effective Concentration 50%
PEL: Permissible Exposure Limit
TLV: Threshold Limit Value
IMDG: International Maritime Dangerous Goods Code
IATA: International Air Transport Association
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
DOT: US Department of Transportation
NFPA: National Fire Protection Association
NIOSH: National Institute for Occupational Safety and Health
OSHA: Occupational Safety and Health Administration
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.