Chemical Safety Data Sheet MSDS / SDS
1,4-DIOXANE-D8
Revision Date:2026-03-21Revision Number:1
Product identifier
- Product name: 1,4-DIOXANE-D8
- CBnumber: CB6722111
- CAS: 17647-74-4
- EINECS Number: 241-628-7
- Synonyms: DIOXANE D8;P-DIOXANE-D8
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordDanger
P308+P313 IF exposed or concerned: Get medical advice/attention.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P240 Ground/bond container and receiving equipment.
P233 Keep container tightly closed.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P202 Do not handle until all safety precautions have been read and understood.
Hazard statements
H351 Suspected of causing cancer
H335 May cause respiratory irritation
H319 Causes serious eye irritation
H225 Highly Flammable liquid and vapour
Substance
- Product name: 1,4-DIOXANE-D8
- Synonyms: DIOXANE D8;P-DIOXANE-D8
- CAS: 17647-74-4
- EC number: 241-628-7
- MF: C4D8O2
- MW: 96.15
4.1 Description of first-aid measures
General adviceShow this material safety data sheet to the doctor in attendance.
If inhaled
After inhalation: fresh air. Call in physician.
In case of skin contact
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Consult a physician.
In case of eye contact
After eye contact: rinse out with plenty of water. Call in ophthalmologist. Remove contact lenses.
If swallowed
After swallowing: immediately make victim drink water (two glasses at most). Consult a physician.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available
4.4 Notes to physician
No data available
5.1 Extinguishing media
Suitable extinguishing mediaWater Foam Carbon dioxide (CO2) Dry powder
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.
5.2 Special hazards arising from the substance or mixture
Carbon oxides
Combustible.
Pay attention to flashback.
Vapors are heavier than air and may spread along floors.
Development of hazardous combustion gases or vapours possible in the event of fire.
Forms explosive mixtures with air at ambient temperatures.
Combustible.
Pay attention to flashback.
Vapors are heavier than air and may spread along floors.
Development of hazardous combustion gases or vapours possible in the event of fire.
Forms explosive mixtures with air at ambient temperatures.
5.3 Advice for firefighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.
Remove container from danger zone and cool with water. Prevent fire extinguishing water from contaminating surface water or the ground water system.
Remove container from danger zone and cool with water. Prevent fire extinguishing water from contaminating surface water or the ground water system.
NFPA 704
2
3
1
| HEALTH | 2 | Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury (e.g. diethyl ether, ammonium phosphate, iodine) | |
| FIRE | 3 | Liquids and solids (including finely divided suspended solids) that can be ignited under almost all ambient temperature conditions . Liquids having a flash point below 22.8 °C (73 °F) and having a boiling point at or above 37.8 °C (100 °F) or having a flash point between 22.8 and 37.8 °C (73 and 100 °F). (e.g. gasoline, acetone) | |
| REACT | 1 | Normally stable, but can become unstable at elevated temperatures and pressures (e.g. propene) | |
| SPEC. HAZ. |
6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance contact. Ensure adequate ventilation. Keep away from heat and sources of ignition.
Evacuate the danger area, observe emergency procedures, consult an expert.
For personal protection see section 8.
Evacuate the danger area, observe emergency procedures, consult an expert.
For personal protection see section 8.
6.2 Environmental precautions
Do not let product enter drains. Risk of explosion.
6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up carefully with liquid-absorbent material (e.g.
Chemizorb®). Dispose of properly. Clean up affected area.
Chemizorb®). Dispose of properly. Clean up affected area.
6.4 Reference to other sections
For disposal see section 13.
7.1 Precautions for safe handling
Advice on safe handlingWork under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols.
Advice on protection against fire and explosion
Keep away from open flames, hot surfaces and sources of ignition.Take precautionary measures against static discharge.
Hygiene measures
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.
For precautions see section 2.2.
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditionsKeep container tightly closed in a dry and well-ventilated place. Keep away from heat and sources of ignition. Keep locked up or in an area accessible only to qualified or authorized persons.
Test for peroxide formation periodically and before distillation.
Storage class
Test for peroxide formation periodically and before distillation.
Storage class (TRGS 510): 3: Flammable liquids
8.1 Control parameters
Ingredients with workplace control parameters| ['Component', 'CAS-No.', 'Value', 'Control\nparameters', 'Basis'] | ['Octadeuterodioxa\nne', '17647-74-\n4', 'PC-TWA', '70 mg/m3', 'Occupational exposure limits for\nhazardous agents in the\nworkplace - Chemical\nhazardous agents.'] | ['', 'Remarks', 'G2B - Possibly carcinogenic to humans\nSkin', None, None] |
|---|
8.2 Exposure controls
Appropriate engineering controlsImmediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.
Personal protective equipment
Eye/face protection
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses
Skin protection
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Full contact
Material: butyl-rubber
Minimum layer thickness: 0.7 mm
Break through time: 480 min
Material tested:Butoject® (KCL 898)
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Splash contact
Material: Viton®
Minimum layer thickness: 0.7 mm
Break through time: 120 min
Material tested:Vitoject® (KCL 890 / Aldrich Z677698, Size M)
Body Protection
Internet: www.kcl.de).
Full contact
Material: butyl-rubber
Minimum layer thickness: 0.7 mm
Break through time: 480 min
Material tested:Butoject® (KCL 898)
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Splash contact
Material: Viton®
Minimum layer thickness: 0.7 mm
Break through time: 120 min
Material tested:Vitoject® (KCL 890 / Aldrich Z677698, Size M)
Flame retardant antistatic protective clothing.
Respiratory protection
required when vapours/aerosols are generated. Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Control of environmental exposure
Do not let product enter drains. Risk of explosion.
Information on basic physicochemical properties
- a) Physical stateclear, liquid
- b) Colorcolorless
- c) OdorNo data available
- d) Melting point/freezing pointNo data available
- e) Initial boiling point and boiling range99 °C - lit.
- f) Flammability (solid, gas)No data available
- g) Upper/lower flammability or explosive limitsNo data available
- h) Flash point5 °C - closed cup
- i) Autoignition temperatureNo data available
- j) Decomposition temperatureNo data available
- k) pHNo data available
- l) ViscosityViscosity, kinematic: No data available
Viscosity, dynamic: No data available - m) Water solubilityMiscible with water.
- n) Partition coefficient n-octanol/waterNo data available
- o) Vapor pressureNo data available
- p) Density1.129 g/cm3 at 25 °C - lit.
- Relative density1.129 g/mL at 25 °C(lit.)
- q) Relative vapor densityNo data available
- r) Particle characteristicsNo data available
- s) Explosive propertiesNo data available
- t) Oxidizing propertiesnone
9.2 Other safety information
No data available
10.1 Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .
10.2 Possibility of hazardous reactions
Risk of explosion with: triethylaluminium lithium aluminium hydride
Triethylamine
Boranes silver perchlorate
Oxygen
Nitric acid with perchloric acid
Raney-nickel with
Hydrogen
Risk of ignition or formation of inflammable gases or vapours with: fire-promoting substances
Exothermic reaction with:
Oxidizing agents
Sulfur trioxide acids
Triethylamine
Boranes silver perchlorate
Oxygen
Nitric acid with perchloric acid
Raney-nickel with
Hydrogen
Risk of ignition or formation of inflammable gases or vapours with: fire-promoting substances
Exothermic reaction with:
Oxidizing agents
Sulfur trioxide acids
10.3 Conditions to avoid
Avoid moisture. Heat.
Warming.
Moisture.
Warming.
Moisture.
10.4 Incompatible materials
No data available
10.5 Hazardous decomposition products
Peroxides
In the event of fire: see section 5
In the event of fire: see section 5
11.1 Information on toxicological effects
Acute toxicityLD50 Oral - Rat - male and female - 5,150 mg/kg (OECD Test Guideline 401)
Remarks: The value is given in analogy to the following substances: 1,4-Dioxane
Symptoms: mucosal irritations, Cough, Shortness of breath, Possible damages:, damage of respiratory tract, Lung edema
LD50 Dermal - Rabbit - 7,378 mg/kg
Remarks: (RTECS)
The value is given in analogy to the following substances: 1,4-Dioxane
Skin corrosion/irritation
Remarks: The value is given in analogy to the following substances: 1,4-Dioxane
Symptoms: mucosal irritations, Cough, Shortness of breath, Possible damages:, damage of respiratory tract, Lung edema
LD50 Dermal - Rabbit - 7,378 mg/kg
Remarks: (RTECS)
The value is given in analogy to the following substances: 1,4-Dioxane
Skin - Rabbit
Result: No skin irritation - 20 h
Remarks: (IUCLID)
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
The value is given in analogy to the following substances: 1,4-Dioxane
Serious eye damage/eye irritation
Result: No skin irritation - 20 h
Remarks: (IUCLID)
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
The value is given in analogy to the following substances: 1,4-Dioxane
Eyes - Rabbit
Result: Eye irritation (OECD Test Guideline 405)
Remarks: The value is given in analogy to the following substances: 1,4-Dioxane
Remarks: (Regulation (EC) No 1272/2008, Annex VI)
Respiratory or skin sensitization
Result: Eye irritation (OECD Test Guideline 405)
Remarks: The value is given in analogy to the following substances: 1,4-Dioxane
Remarks: (Regulation (EC) No 1272/2008, Annex VI)
Maximization Test - Guinea pig
Result: negative (Regulation (EC) No. 440/2008, Annex, B.6)
Remarks: The value is given in analogy to the following substances: 1,4-Dioxane
Germ cell mutagenicity
Result: negative (Regulation (EC) No. 440/2008, Annex, B.6)
Remarks: The value is given in analogy to the following substances: 1,4-Dioxane
Test Type: Ames test
Test system: Salmonella typhimurium
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 471
Result: negative
Remarks: The value is given in analogy to the following substances: 1,4-DioxaneTest Type:
In vitro mammalian cell gene mutation test
Test system: Chinese hamster ovary cells
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 476
Result: negative
Remarks: The value is given in analogy to the following substances: 1,4-DioxaneTest Type:
Chromosome aberration test in vitro
Test system: Chinese hamster ovary cells
Metabolic activation: with and without metabolic activation
Result: negative
Remarks: (ECHA)
The value is given in analogy to the following substances: 1,4-Dioxane
Test Type: unscheduled DNA synthesis assay
Species: Rat
Cell type: Liver cells
Application Route: Oral
Result: negative
Remarks: (ECHA)
The value is given in analogy to the following substances: 1,4-Dioxane
Carcinogenicity
Test system: Salmonella typhimurium
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 471
Result: negative
Remarks: The value is given in analogy to the following substances: 1,4-DioxaneTest Type:
In vitro mammalian cell gene mutation test
Test system: Chinese hamster ovary cells
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 476
Result: negative
Remarks: The value is given in analogy to the following substances: 1,4-DioxaneTest Type:
Chromosome aberration test in vitro
Test system: Chinese hamster ovary cells
Metabolic activation: with and without metabolic activation
Result: negative
Remarks: (ECHA)
The value is given in analogy to the following substances: 1,4-Dioxane
Test Type: unscheduled DNA synthesis assay
Species: Rat
Cell type: Liver cells
Application Route: Oral
Result: negative
Remarks: (ECHA)
The value is given in analogy to the following substances: 1,4-Dioxane
Presumed to have carcinogenic potential for humans
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
May cause respiratory irritation. - Respiratory system
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
The value is given in analogy to the following substances: 1,4-Dioxane
Specific target organ toxicity - repeated exposure
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
The value is given in analogy to the following substances: 1,4-Dioxane
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
11.2 Additional Information
Repeated dose toxicity - Rat - male - Oral - 716 Days - NOAEL (No observed adverse effect level) - 9.6 mg/kg
Remarks: (ECHA)
The value is given in analogy to the following substances: 1,4-Dioxane
Nausea, Vomiting, Weakness, Dizziness, Vertigo, Headache, Sweating, loss of appetite,
Kidney injury may occur., Liver injury may occur.
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
The substance has delayed effects.
After absorption:
Headache
Dizziness
Nausea
Vomiting
Absorption can result in damage to:
Liver
Kidney
Other dangerous properties can not be excluded.
This substance should be handled with particular care.
Remarks: (ECHA)
The value is given in analogy to the following substances: 1,4-Dioxane
Nausea, Vomiting, Weakness, Dizziness, Vertigo, Headache, Sweating, loss of appetite,
Kidney injury may occur., Liver injury may occur.
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
The substance has delayed effects.
After absorption:
Headache
Dizziness
Nausea
Vomiting
Absorption can result in damage to:
Liver
Kidney
Other dangerous properties can not be excluded.
This substance should be handled with particular care.
12.1 Toxicity
Toxicity to daphnia semi-static test EC50 - Daphnia magna (Water flea) - > 1,000 mg/l and other aquatic - 48 h invertebrates (OECD Test Guideline 202)
Remarks: The value is given in analogy to the following substances: 1,4-Dioxane
Toxicity to algae static test ErC50 - Pseudokirchneriella subcapitata (green algae) - > 1,000 mg/l - 72 h (OECD Test Guideline 201)
Remarks: The value is given in analogy to the following substances: 1,4-Dioxane
Toxicity to flow-through test NOEC - Pimephales promelas (fathead minnow) - > fish(Chronic toxicity) 103 mg/l - 32 d
Remarks: (ECHA)
The value is given in analogy to the following substances: 1,4-
Dioxane
Toxicity to daphnia NOEC - Daphnia magna (Water flea) - 1,000 mg/l - 21 d and other aquatic (OECD Test Guideline 211) invertebrates(Chronic Remarks: The value is given in analogy to the following substances: toxicity) 1,4-Dioxane
Remarks: The value is given in analogy to the following substances: 1,4-Dioxane
Toxicity to algae static test ErC50 - Pseudokirchneriella subcapitata (green algae) - > 1,000 mg/l - 72 h (OECD Test Guideline 201)
Remarks: The value is given in analogy to the following substances: 1,4-Dioxane
Toxicity to flow-through test NOEC - Pimephales promelas (fathead minnow) - > fish(Chronic toxicity) 103 mg/l - 32 d
Remarks: (ECHA)
The value is given in analogy to the following substances: 1,4-
Dioxane
Toxicity to daphnia NOEC - Daphnia magna (Water flea) - 1,000 mg/l - 21 d and other aquatic (OECD Test Guideline 211) invertebrates(Chronic Remarks: The value is given in analogy to the following substances: toxicity) 1,4-Dioxane
12.2 Persistence and degradability
Biodegradability aerobic - Exposure time 29 d
Result: < 10 % - Not readily biodegradable.
(OECD Test Guideline 301F)
Remarks: The value is given in analogy to the following substances: 1,4-Dioxane
Result: < 10 % - Not readily biodegradable.
(OECD Test Guideline 301F)
Remarks: The value is given in analogy to the following substances: 1,4-Dioxane
12.3 Bioaccumulative potential
Bioaccumulation Cyprinus carpio (Carp) - 10 mg/l(Octadeuterodioxane)
Bioconcentration factor (BCF): 0.3 - 0.7 (OECD Test Guideline 305C)
Remarks: The value is given in analogy to the following substances: 1,4-Dioxane
Bioconcentration factor (BCF): 0.3 - 0.7 (OECD Test Guideline 305C)
Remarks: The value is given in analogy to the following substances: 1,4-Dioxane
12.4 Mobility in soil
No data available
12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
12.6 Endocrine disrupting properties
No data available
12.7 Other adverse effects
Forms toxic mixtures in water, dilution measures notwithstanding.
Discharge into the environment must be avoided.
Discharge into the environment must be avoided.
13.1 Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company.
Offer surplus and non-recyclable solutions to a licensed disposal company.
14.1 UN number
ADR/RID: 1165
IMDG: 1165
IATA-DGR: 1165
IMDG: 1165
IATA-DGR: 1165
14.2 UN proper shipping name
ADR/RID: DIOXANE
IMDG: DIOXANE
IATA-DGR: Dioxane
IMDG: DIOXANE
IATA-DGR: Dioxane
14.3 Transport hazard class(es)
ADR/RID: 3
IMDG: 3
IATA-DGR: 3
IMDG: 3
IATA-DGR: 3
14.4 Packaging group
ADR/RID: II
IMDG: II
IATA-DGR: II
IMDG: II
IATA-DGR: II
14.5 Environmental hazards
ADR/RID: no
IMDG Marine pollutant: no
IATA-DGR: no
IMDG Marine pollutant: no
IATA-DGR: no
14.6 Special precautions for user
Based on chemical properties, choose appropriate tools and conditions of transport.
Transporting tools shall be equipped with appropriate and sufficient firefighting equipment and emergency leaking installations. If transporting by road, please go along the specified route.
Transporting tools shall be equipped with appropriate and sufficient firefighting equipment and emergency leaking installations. If transporting by road, please go along the specified route.
14.7 Incompatible materials
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
National regulatory information
Law on the Prevention and Control of Occupational Diseases
Regulations on Safety Management of Hazardous Chemicals
Catalogue of Hazardous Chemicals : Listed
Measures on the Environmental Administration of New Chemical Substances Registration
Registration/Notification number : B1A222220259
Downstream users need to comply with the conditions of safe use of the chemical, understand the environmental and health hazard and risk management measures identified on the SDS as well as the local/national regulations concerning the chemical.
Other regulations
Please pay attention on the waste treatment should also comply with local regulations requirement.
Law on the Prevention and Control of Occupational Diseases
Regulations on Safety Management of Hazardous Chemicals
Catalogue of Hazardous Chemicals : Listed
Measures on the Environmental Administration of New Chemical Substances Registration
Registration/Notification number : B1A222220259
Downstream users need to comply with the conditions of safe use of the chemical, understand the environmental and health hazard and risk management measures identified on the SDS as well as the local/national regulations concerning the chemical.
Other regulations
Please pay attention on the waste treatment should also comply with local regulations requirement.
Abbreviations and acronyms
CAS: Chemical Abstracts Service
TWA: Time-Weighted Average
STEL: Short-Term Exposure Limit
LD50: Lethal Dose 50%
LC50: Lethal Concentration 50%
EC50: Effective Concentration 50%
PEL: Permissible Exposure Limit
TLV: Threshold Limit Value
IMDG: International Maritime Dangerous Goods Code
IATA: International Air Transport Association
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
DOT: US Department of Transportation
NFPA: National Fire Protection Association
NIOSH: National Institute for Occupational Safety and Health
OSHA: Occupational Safety and Health Administration
TWA: Time-Weighted Average
STEL: Short-Term Exposure Limit
LD50: Lethal Dose 50%
LC50: Lethal Concentration 50%
EC50: Effective Concentration 50%
PEL: Permissible Exposure Limit
TLV: Threshold Limit Value
IMDG: International Maritime Dangerous Goods Code
IATA: International Air Transport Association
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
DOT: US Department of Transportation
NFPA: National Fire Protection Association
NIOSH: National Institute for Occupational Safety and Health
OSHA: Occupational Safety and Health Administration
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.
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