ChemicalBook
Chemical Safety Data Sheet MSDS / SDS

2,2-BIS[4-(2-HYDROXY-3-METHACRYLOXYPROPOXY)PHENYL]PROPANE

Revision Date:2026-03-21Revision Number:1

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

  • Product name: 2,2-BIS[4-(2-HYDROXY-3-METHACRYLOXYPROPOXY)PHENYL]PROPANE
  • CBnumber: CB2199669
  • CAS: 1565-94-2
  • EINECS Number: 216-367-7
  • Synonyms: BIS-GMA;Bisphenol A bis(2-hydroxy-3-methacryloxypropyl) ether

Relevant identified uses of the substance or mixture and uses advised against

  • Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
  • Uses advised against: none

Company Identification

  • Company: Chemicalbook
  • Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
  • Telephone: 010-86108875

SECTION 2: Hazards identification

GHS Label elements, including precautionary statements

  • Symbol(GHS)
  • Signal wordDanger
Precautionary statements
P333+P313 IF SKIN irritation or rash occurs: Get medical advice/attention.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P272 Contaminated work clothing should not be allowed out of the workplace.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
Hazard statements
H318 Causes serious eye damage
H317 May cause an allergic skin reaction

SECTION 3: Composition/information on ingredients

Substance

  • Product name: 2,2-BIS[4-(2-HYDROXY-3-METHACRYLOXYPROPOXY)PHENYL]PROPANE
  • Synonyms: BIS-GMA;Bisphenol A bis(2-hydroxy-3-methacryloxypropyl) ether
  • CAS: 1565-94-2
  • EC number: 216-367-7
  • MF: C29H36O8
  • MW: 512.59

SECTION 4: First aid measures

General advice

Show this safety data sheet to the doctor in attendance.

If inhaled

After inhalation: fresh air.

In case of skin contact

In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Consult a physician.

In case of eye contact

After eye contact: rinse out with plenty of water. Immediately call in ophthalmologist. Remove contact lenses.

If swallowed

After swallowing: immediately make victim drink water (two glasses at most). Consult a physician.

Most important symptoms and effects, both acute and delayed

The most important known symptoms and effects are described in the labelling (see section 2) and/or in section 11

Protection of first-aiders

For personal protection see section 8.

Notes to physician

No data available

SECTION 5: Firefighting measures

Suitable extinguishing media

Water Foam Carbon dioxide (CO2) Dry powder

Unsuitable extinguishing media

For this substance/mixture no limitations of extinguishing agents are given.

Specific hazards during fire fighting

Combustible. Vapours are heavier than air and may spread along floors. Forms explosive mixtures with air on intense heating. Development of hazardous combustion gases or vapours possible in the event of fire.

Hazardous combustion products

Carbon oxides

Specific extinguishing methods

Prevent fire extinguishing water from contaminating surface water or the ground water system.

Special protective equipment for fire-fighters

Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.

SECTION 6: Accidental release measures

Personal precautions, protective equipment and emergency procedures

Advice for non-emergency personnel: Do not breathe vapours, aerosols. Avoid substance contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an expert. Advice for emergency responders: For personal protection see section 8.

Environmental precautions

Do not let product enter drains.

Methods and materials for containment and cleaning up

Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up with liquid-absorbent material (e.g. Chemizorb® ). Dispose of properly. Clean up affected area.

SECTION 7: Handling and storage

Handling

Avoidance of contact
Strong oxidizing agents

Storage

Further information on storage conditions
Tightly closed.
Storage class
10, Combustible liquids
Recommended storage temperature
2 - 8 °C
Further information on storage stability
Light sensitive.
Packaging material
Suitable material: Amber HR-HDPE Bottle/Jar

SECTION 8: Exposure controls/personal protection

Ingredients with workplace control parameters

Biological occupational exposure limits

Engineering measures

No data available

Personal protective equipment

Respiratory protection
required when vapours/aerosols are generated.
Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Recommended Filter type
Filter type ABEK
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented.
Eye/face protection
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Tightly fitting safety goggles
Skin and body protection
protective clothing
Hand protection
Remarks
required
Hygiene measures
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.

SECTION 9: Physical and chemical properties

Information on basic physicochemical properties

  • Vapor pressureNo data available
  • Lower explosion limit / Lower flammability limitNo data available
  • Upper explosion limit / Upper flammability limitNo data available
  • Burning rateNo data available
  • Flammability (liquids)No data available
  • Flammability (solid, gas)No data available
  • Evaporation rateNo data available
  • Flash point110 °C
  • Boiling point/boiling range670.3±55.0 °C(Predicted)
  • Melting point/ rangeNo data available
  • pHNo data available
  • Odor ThresholdNo data available
  • OdorNo data available
  • ColorNo data available
  • Appearanceliquid
  • Refractive index1.552
  • Particle characteristics Particle sizeNo data available
  • Molecular weight512.59 g/mol
  • Oxidizing propertiesnone
  • Explosive propertiesNot classified as explosive.
  • Flow timeNo data available
  • Viscosity, kinematicNo data available
  • Viscosity, dynamicNo data available
  • Decomposition temperatureNo data available
  • Autoignition temperatureNo data available
  • Partition coefficient: n-octanol/waterNo data available
  • Water solubilityNo data available
  • Density1.161 g/mL (25 °C)
    Method: lit.
  • Relative density1.161 g/mL at 25 °C(lit.)
  • Relative vapor densityNo data available

SECTION 10: Stability and reactivity

Reactivity

Forms explosive mixtures with air on intense heating. A range from approx. 15 Kelvin below the flash point is to be rated as critical.

Chemical stability

The product is chemically stable under standard ambient conditions (room temperature) .

Possibility of hazardous reactions

Violent reactions possible with: Strong oxidizing agents

Conditions to avoid

Strong heating.

Incompatible materials

Strong oxidizing agents

Hazardous decomposition products

In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Acute toxicity
Acute toxicity estimate Oral - > 5,000 mg/kg (Calculation method)
Inhalation: No data available
Dermal: No data available
Skin corrosion/irritation
Classified based on available data. For more details, see section 2
Serious eye damage/eye irritation
Remarks: No data available
Respiratory or skin sensitization
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
Classified based on available data. For more details, see section 2
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2

11.2 Additional Information

RTECS: UD3438000
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.

SECTION 12: Ecological information

Ecotoxicity

Components:

hydroquinone monomethyl ether:

Toxicity to fish
LC50 (Oncorhynchus mykiss (rainbow trout)): 28.5 mg/l Exposure time: 96 h Test Type: flow-through test Analytical monitoring: yes Method: OECD Test Guideline 203
Toxicity to daphnia and other aquatic invertebrates
EC50 (Daphnia magna (Water flea)): 3 mg/l End point: Immobilization Exposure time: 48 h Test Type: static test Analytical monitoring: yes Method: OECD Test Guideline 202 GLP: yes NOEC (Daphnia magna (Water flea)): 0.68 mg/l Exposure time: 21 d Test Type: semi-static test Analytical monitoring: yes GLP: yes
Toxicity to algae/aquatic plants
EC50 (Pseudokirchneriella subcapitata (green algae)): 54.7 mg/l Exposure time: 72 h Test Type: static test Analytical monitoring: yes Method: OECD Test Guideline 201 GLP: yes

Ecotoxicology Assessment

Chronic aquatic toxicity
Harmful to aquatic life with long lasting effects.

hydroquinone:

Toxicity to fish
LC50 (Oncorhynchus mykiss (rainbow trout)): 0.638 mg/l End point: mortality Exposure time: 96 h Test Type: flow-through test Analytical monitoring: yes Method: OECD Test Guideline 203
Toxicity to daphnia and other aquatic invertebrates
EC50 (Daphnia magna (Water flea)): 0.134 mg/l End point: Immobilization Exposure time: 48 h Test Type: semi-static test Analytical monitoring: yes Method: OECD Test Guideline 202 GLP: yes
Toxicity to algae/aquatic plants
ErC50 (Pseudokirchneriella subcapitata): 0.33 mg/l Exposure time: 72 h Test Type: static test Analytical monitoring: yes Method: OECD Test Guideline 201 GLP: yes NOEC (Pseudokirchneriella subcapitata): 0.019 mg/l Exposure time: 72 h Test Type: static test Analytical monitoring: yes Method: OECD Test Guideline 201 GLP: yes
Toxicity to fish (Chronic toxicity)
NOEC (Pimephales promelas (fathead minnow)): >= 0.1 mg/l End point: reproduction rate Exposure time: 32 d Test Type: flow-through test Analytical monitoring: yes Method: OECD Test Guideline 210 GLP: yes
Toxicity to daphnia and other aquatic invertebrates (Chronic toxicity)
LC50 (Daphnia magna (Water flea)): 0.061 mg/l End point: mortality Exposure time: 21 d Test Type: semi-static test Analytical monitoring: yes Method: OECD Test Guideline 211 GLP: yes

Ecotoxicology Assessment

Acute aquatic toxicity
Very toxic to aquatic life.
Chronic aquatic toxicity
Very toxic to aquatic life with long lasting effects.

Persistence and degradability

Components:

hydroquinone monomethyl ether:

Biodegradability
aerobic Inoculum: activated sludge Result: Readily biodegradable. Biodegradation: 86 % Exposure time: 28 d Method: OECD Test Guideline 301C

hydroquinone:

Biodegradability
aerobic Inoculum: activated sludge Concentration: 100 mg/l Result: Readily biodegradable. Biodegradation: 70 % Exposure time: 14 d Method: OECD Test Guideline 301C

Bioaccumulative potential

Components:

hydroquinone monomethyl ether:

Bioaccumulation
Remarks: Bioaccumulation is unlikely.

hydroquinone:

Partition coefficient: noctanol/water
log Pow: 0.59 (20 - 25 °C) Remarks: Bioaccumulation is not expected.

Mobility in soil

Components:

hydroquinone monomethyl ether:

Distribution among environmental compartments
Adsorption/Soil Koc: 55.7 Remarks: (Lit.)

Other adverse effects

No data available

SECTION 13: Disposal considerations

Disposal methods

Waste from residues
Offer surplus and non-recyclable solutions to a licensed disposal company.

SECTION 14: Transport information

International Regulations

IATA-DGR

Not regulated as a dangerous good
UN/ID No. : Not applicable
Proper shipping name : Not applicable
Class : Not applicable
Subsidiary risk : Not applicable
Packing group : Not applicable
Labels : Not applicable
Packing instruction (cargo aircraft) : Not applicable
Packing instruction (passenger aircraft) : Not applicable

IMDG-Code

Not regulated as a dangerous good
UN number : Not applicable
Proper shipping name : Not applicable
Class : Not applicable
Subsidiary risk : Not applicable
Packing group : Not applicable
Labels : Not applicable
EmS Code : Not applicable
Marine pollutant : no

Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

Not applicable for product as supplied.

National Regulations

JT/T 617

UN number : Not applicable
Proper shipping name : Not applicable
Class : Not applicable
Subsidiary risk : Not applicable
Packing group : Not applicable
Labels : Not applicable
Environmentally hazardous : no

Special precautions for user

Remarks : Not classified as dangerous in the meaning of transport regulations.

SECTION 15: Regulatory information

Catalogue of Hazardous Chemicals : This product is not listed in the catalogue of hazardous chemicals, but it meets the definition of hazardous chemicals and its principles of determination.

National regulatory information

Law on the Prevention and Control of Occupational Diseases

Regulations on Safety Management of Hazardous Chemicals

Identification of Major Hazard Installations for Hazardous Chemicals (GB 18218)

Not listed

Hazardous Chemicals for Priority Management

Not listed under SAWS

Catalogue of Specially Controlled Hazardous

Not listed Chemicals

List of Explosive Precursors

Not listed

Regulations on Labour Protection in Workplaces where Toxic Substances are Used

Catalogue of Highly Toxic Chemicals

Not listed

Regulation of Environmental Management on the First Import of Chemicals and the Import and Export of Toxic Chemicals

China Severely Restricted Toxic Chemicals for Import and Export

Not listed

Regulation on the Administration of Precursor Chemicals

Catalogue and Classification of Precursor Chemicals

Not listed

Regulations on the Administration of Controlled Chemicals

List of Controlled Chemicals

Not listed

Regulations of Ozone Depleting Substances Management

List of Controlled Ozone Depleting Substances

Not listed

List of Controlled Ozone Depleting Substances Import and Export

Not listed

Environmental Protection Law

List of Priority Controlled Chemicals

Not listed

List of Key Controlled New Pollutants

Not listed

SECTION 16: Other information

Full text of other abbreviations

ACGIH
USA. ACGIH Threshold Limit Values (TLV)
ACGIH BEI
ACGIH - Biological Exposure Indices (BEI)
GBZ 2.1-2007
Occupational exposure limits for hazardous agents in the workplace - Chemical hazardous agents.
ACGIH / TWA
8-hour, time-weighted average
GBZ 2.1-2007 / PC-TWA
Permissible concentration - time weighted average
GBZ 2.1-2007 / PC-STEL AIIC - Australian Invent Transport by Land of Bra bw - Body weight; CMR Standard of the German List (Canada); ECx - Conc associated with x% respo Chemical Substances (Jap response; ERG - Emerge GLP - Good Laboratory P cer; IATA - International Construction and Equipm Half maximal inhibitory c tion; IECSC - Inventory o tional Maritime Dangerou Industrial Safety and H Standardisation; KECI - K tration to 50 % of a test (Median Lethal Dose); MA lution from Ships; MERC of Dangerous Goods; n.o. - No Observed (Adverse) fect Level; NOELR - No Norm; NTP - National Toxi icals; OECD - Organisatio fice of Chemical Safety a and Toxic substance; PIC stances; (Q)SAR - (Quant (EC) No 1907/2006 of th Registration, Evaluation, Accelerating Decompositi Chemical Substance Inve Thailand Existing Chemica States); UN - United Nat Transport of Dangerous WHMIS - Workplace Hazar
Permissible concentration - short term exposure limit ry of Industrial Chemicals
ANTT - National Agency for il
ASTM - American Society for the Testing of Materials
- Carcinogen, Mutagen or Reproductive Toxicant
DIN nstitute for Standardisation
DSL - Domestic Substances ntration associated with x% response
ELx - Loading rate se
EmS - Emergency Schedule
ENCS - Existing and New n)
ErCx - Concentration associated with x% growth rate cy Response Guide
GHS - Globally Harmonised System
actice
IARC - International Agency for Research on Canir Transport Association
IBC - International Code for the nt of Ships carrying Dangerous Chemicals in Bulk
IC50 ncentration
ICAO - International Civil Aviation Organiza- Existing Chemical Substances in China
IMDG - Interna- Goods
IMO - International Maritime Organisation
ISHL alth Law (Japan)
ISO - International Organisation for rea Existing Chemicals Inventory
LC50 - Lethal Concenopulation
LD50 - Lethal Dose to 50% of a test population POL - International Convention for the Prevention of Pol- SUR - The Agreement for the Facilitation of the Transport . - Not Otherwise Specified
Nch - Chilean Norm
NO(A)EC ffect Concentration
NO(A)EL - No Observed (Adverse) Efbservable Effect Loading Rate
NOM - Official Mexican ology Program
NZIoC - New Zealand Inventory of Chemfor Economic Co-operation and Development
OPPTS - Ofd Pollution Prevention
PBT - Persistent, Bioaccumulative S - Philippines Inventory of Chemicals and Chemical Subtative) Structure Activity Relationship
REACH - Regulation European Parliament and of the Council concerning the uthorisation and Restriction of Chemicals
SADT - Selfn Temperature
SDS - Safety Data Sheet
TCSI - Taiwan tory
TDG - Transportation of Dangerous Goods
TECI s Inventory
TSCA - Toxic Substances Control Act (United ons
UNRTDG - United Nations Recommendations on the oods
vPvB - Very Persistent and Very Bioaccumulative
ous Materials Information System
Disclaimer:

The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.

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