Chemical Safety Data Sheet MSDS / SDS
2-Piperidineacetic acid, alpha-phenyl-, methyl ester, hydrochloride, (R*,R*)- (+-)-
Revision Date:2026-05-31Revision Number:1
Product identifier
- Product name: 2-Piperidineacetic acid, alpha-phenyl-, methyl ester, hydrochloride, (R*,R*)- (+-)-
- CBnumber: CB32494103
- CAS: 23655-65-4
- Synonyms: Dl-threo-methylphenidate hydrochloride,rac-threo-Methylphenidate Hydrochloride
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordDanger
P501 Dispose of contents/container to..…
P405 Store locked up.
P342+P311 IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P304+P341 IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P330 Rinse mouth.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P284 Wear respiratory protection.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P270 Do not eat, drink or smoke when using this product.
P264 Wash skin thouroughly after handling.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P202 Do not handle until all safety precautions have been read and understood.
P201 Obtain special instructions before use.
Hazard statements
H360 May damage fertility or the unborn child
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled
H302 Harmful if swallowed
Substance
- Product name: 2-Piperidineacetic acid, alpha-phenyl-, methyl ester, hydrochloride, (R*,R*)- (+-)-
- Synonyms: Dl-threo-methylphenidate hydrochloride,rac-threo-Methylphenidate Hydrochloride
- CAS: 23655-65-4
- MF: C14H20ClNO2
- MW: 269.77
Description of first aid measures
General information
Symptoms of poisoning may even occur after several hours; therefore medical observation for at least 48 hours after the accident.
After inhalation
Supply fresh air and to be sure call for a doctor.
In case of unconsciousness place patient stably in side position for transportation.
In case of unconsciousness place patient stably in side position for transportation.
After skin contact
Immediately wash with water and soap and rinse thoroughly.
After eye contact
Rinse opened eye for several minutes under running water.
After swallowing
Immediately call a doctor.
Most important symptoms and effects, both acute and delayed
No further relevant information available.
Indication of any immediate medical attention and special treatment needed
No further relevant information available.
Extinguishing media
Suitable extinguishing agents
Use fire fighting measures that suit the environment.
A solid water stream may be inefficient.
A solid water stream may be inefficient.
Special hazards arising from the substance or mixture
No further relevant information available.
Advice for firefighters
Protective equipment
No special measures required.
NFPA 704
2
0
0
| HEALTH | 2 | Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury (e.g. diethyl ether, ammonium phosphate, iodine) | |
| FIRE | 0 | Materials that will not burn under typical fire conditions, including intrinsically noncombustible materials such as concrete, stone, and sand. Materials that will not burn in air when exposed to a temperature of 820 °C (1,500 °F) for a period of 5 minutes.(e.g. Carbon tetrachloride) | |
| REACT | 0 | Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2) | |
| SPEC. HAZ. |
Personal precautions, protective equipment and emergency procedures
Not required.
Environmental precautions
Do not allow to enter sewers/ surface or ground water.
Methods and material for containment and cleaning up
Dispose contaminated material as waste according to section 13.
Protective Action Criteria for Chemicals
PAC-1
Substance is not listed.
PAC-2
Substance is not listed.
PAC-3
Substance is not listed.
Substanceis not listed.
Reference to other sections
See Section 7 for informationon safe handling.
See Section 8 for informationon personal protection equipment.
See Section 13 fordisposalinfor mation.
Substanceis not listed.
Reference to other sections
See Section 7 for informationon safe handling.
See Section 8 for informationon personal protection equipment.
See Section 13 fordisposalinfor mation.
Precautions for safe handling
Ensure good ventilation/exhaustion at the workplace.
Information about protection against explosions and fires
No special measures required.
Conditions for safe storage, including any incompatibilities
Storage
Store in accordance with information listed on the product insert.
Requirements to be met by storerooms and receptacles
No special requirements.
Information about storage in one common storage facility
Not required.
Further information about storage conditions
None.
Specific end use(s)
No further relevant information available.
Control parameters
Components with limit values that require monitoring at the workplace
Not required.
Additional information
The lists that were valid during the creation were used as basis.
Exposure controls
Appropriate engineering controls
No further data; see section 7.
Personal protective equipment
General protective and hygienic measures
Keep away from foodstuffs, beverages and feed.
Immediately remove all soiled and contaminated clothing.
Wash hands before breaks and at the end of work.
Immediately remove all soiled and contaminated clothing.
Wash hands before breaks and at the end of work.
Breathing equipment
In case of brief exposure or low pollution use respiratory filter device. In case of intensive or longer exposure use respiratory protective device that is independent of circulating air.
Protection of hands
Protective gloves
The glove material has to be impermeable and resistant to the product/ the substance/ the preparation.
Due to missing tests no recommendation to the glove material can be given for the product/ the preparation/ the chemical mixture.
Selection of the glove material on consideration of the penetration times, rates of diffusion and the degradation
The glove material has to be impermeable and resistant to the product/ the substance/ the preparation.
Due to missing tests no recommendation to the glove material can be given for the product/ the preparation/ the chemical mixture.
Selection of the glove material on consideration of the penetration times, rates of diffusion and the degradation
Material of gloves
The selection of the suitable gloves does not only depend on the material, but also on further marks of quality and varies from manufacturer to manufacturer.
Penetration time of glove material
The exact break through time has to be found out by the manufacturer of the protective gloves and has to be observed.
Eye protection
Not required.
Information on basic physicochemical properties
- Ignition temperatureNot determined.
- FormSolid
- Particle characteristicsNot determined.
- Vapor DensityNot applicable.
- Relative DensityNot determined.
- DensityNot determined.
- Vapor PressureNot applicable.
- Partition coefficient (n-octanol/water)Not determined.
- WaterNot determined.
- Solubility in / Miscibility withDMF: 14 mg/ml; DMSO: 14 mg/ml; Ethanol: 25 mg/ml; PBS (pH 7.2): 10 mg/ml
- DynamicNot applicable.
- SOLUBILITYDMF: 14 mg/ml; DMSO: 14 mg/ml; Ethanol: 25 mg/ ml; PBS (pH 7.2): 10 mg/ml
- KinematicNot applicable.
- pHNot applicable.
- Decomposition temperatureNot determined.
- Flash pointNot applicable.
- Explosion limitsLower: Not determined.
Upper: Not determined. - FlammabilityProduct is not flammable.
- Boiling point/Boiling rangeUndetermined.
- Melting point/Melting rangeUndetermined.
- Odor ThresholdNot determined.
- Molecular Weight269.8 g/mol
- Structural FormulaC14H19NO2 HCl
- OdorCharacteristic
- ColorNot determined.
- Physical StateSolid
- Evaporation RateNot applicable.
- Danger of explosionProduct does not present an explosion hazard.
Reactivity
No further relevant information available.
Chemical stability
Thermal decomposition / conditions to be avoided
No decomposition if used according to specifications.
Possibility of hazardous reactions
No dangerous reactions known.
Conditions to avoid
No further relevant information available.
Incompatible materials
strong oxidizing agents
Hazardous decomposition products
No dangerous decomposition products known.
Information on toxicological effects
Acute toxicity
Primary irritant effect
on the skin
No irritant effect.
on the eye
No irritating effect.
Sensitization
Sensitization
possible through inhalation.
Sensitization
possible through skin contact.
Additional toxicological information
Interactive effects
No interactive effects between components are known.
Carcinogenic categories
IARC (International Agency for Research on Cancer)
Substance is not listed.
NTP (National Toxicology Program)
Substance is not listed.
OSHA-Ca (Occupational Safety & Health Administration)
Substance is not listed.
Alternative sources for toxicological information
No non-standard sources for toxicological information where used.
Toxicity
Aquatic toxicity
No further relevant information available.
Persistence and degradability
No further relevant information available.
Bioaccumulative potential
No further relevant information available.
Mobility in soil
No further relevant information available.
Results of PBT and vPvB assessment
PBT
Not applicable.
vPvB
Not applicable.
PBT:
Not applicable.
vPvB:
Not applicable.
Other adverse effects
Additional ecological information
General notes
Water hazard class 1 (Self-assessment) slightly hazardous for water
Do not allow undiluted product or large quantities of it to reach ground water, water course or sewage system.
Do not allow undiluted product or large quantities of it to reach ground water, water course or sewage system.
Waste treatment methods
Recommendation
Must not be disposed of together with household garbage. Do not allow product to reach sewage system.
Uncleaned packagings
Recommendation
Disposal must be made according to official regulations.
UN-Number
DOT, IMDG, IATA not regulated
UN proper shipping name
DOT, IMDG, IATA not regulated
Transport hazard class(es)
DOT, ADN, IMDG, IATA
Class not regulated
Class not regulated
Packing group
DOT, IMDG, IATA not regulated
Environmental hazards
Not applicable.
Special precautions for user
Not applicable.
Transport in bulk according to Annex II of MARPOL73/78 and the IBC Code
MARPOL73/78 and the IBC Code Not applicable.
UN "Model Regulation"
not regulated
Safety, health and environmental regulations/legislation specific for the substance or mixture
No further relevant information available.
Sara
| Section 355 (extremely hazardous substances): | Substance is not listed. |
| Section 313 (Specific toxic chemical listings): | Substance is not listed. |
| TSCA (Toxic Substances Control Act): | Substance is not listed. |
| Hazardous Air Pollutants: | Substance is not listed. |
| Chemicals known to cause cancer: | Substance is not listed. |
| Chemicals known to cause reproductive toxicity for females: | Substance is not listed. |
| Chemicals known to cause reproductive toxicity for males: | Substance is not listed. |
| Chemicals known to cause developmental toxicity: | Substance is not listed. |
Carcinogenic categories
| EPA (Environmental Protection Agency): | Substance is not listed. |
TLV (Threshold Limit Value)
Substance is not listed.
NIOSH-Ca (National Institute for Occupational Safety and Health)
Substance is not listed.
Chemical safety assessment
A Chemical Safety Assessment has not been carried out.
Abbreviations and acronyms
IMDG: International Maritime Code for Dangerous Goods
DOT: US Department of Transportation
IATA: International Air Transport Association
EINECS: European Inventory of Existing Commercial Chemical Substances
CAS: Chemical Abstracts Service (division of the American Chemical Society)
NFPA: National Fire Protection Association (USA)
HMIS: Hazardous Materials Identification System (USA)
PBT: Persistent, Bioaccumulative and Toxic vPvB: very Persistent and very Bioaccumulative
NIOSH: National Institute for Occupational Safety
OSHA: Occupational Safety & Health
TLV: Threshold Limit Value
PEL: Permissible Exposure Limit
REL: Recommended Exposure Limit
Acute toxicity - oral 4: Acute toxicity – Category 4
Sensitization - respiratory 1: Respiratory sensitisation – Category 1
Sensitization - skin 1: Skin sensitisation – Category 1
Specific target organ toxicity (single exposure) 3: Specific target organ toxicity (single exposure) – Category 3
DOT: US Department of Transportation
IATA: International Air Transport Association
EINECS: European Inventory of Existing Commercial Chemical Substances
CAS: Chemical Abstracts Service (division of the American Chemical Society)
NFPA: National Fire Protection Association (USA)
HMIS: Hazardous Materials Identification System (USA)
PBT: Persistent, Bioaccumulative and Toxic vPvB: very Persistent and very Bioaccumulative
NIOSH: National Institute for Occupational Safety
OSHA: Occupational Safety & Health
TLV: Threshold Limit Value
PEL: Permissible Exposure Limit
REL: Recommended Exposure Limit
Acute toxicity - oral 4: Acute toxicity – Category 4
Sensitization - respiratory 1: Respiratory sensitisation – Category 1
Sensitization - skin 1: Skin sensitisation – Category 1
Specific target organ toxicity (single exposure) 3: Specific target organ toxicity (single exposure) – Category 3
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.
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