Chemical Safety Data Sheet MSDS / SDS
DL-Dithiothreitol
Revision Date:2026-03-21Revision Number:1
Product identifier
- Product name: DL-Dithiothreitol
- CBnumber: CB3342918
- CAS: 27565-41-9
- EINECS Number: 248-531-9
- Synonyms: Cleland's reagent
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordWarning
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P264 Wash skin thouroughly after handling.
P362 Take off contaminated clothing and wash before reuse.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P321 Specific treatment (see … on this label).
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P264 Wash skin thouroughly after handling.
P501 Dispose of contents/container to..…
P330 Rinse mouth.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P270 Do not eat, drink or smoke when using this product.
P264 Wash skin thouroughly after handling.
Hazard statements
H315 Causes skin irritation
H335 May cause respiratory irritation
H302 Harmful if swallowed
H319 Causes serious eye irritation
Substance
- Product name: DL-Dithiothreitol
- Synonyms: Cleland's reagent
- CAS: 27565-41-9
- EC number: 248-531-9
- MF: C4H10O2S2
- MW: 154.25
First Aid Measures
General adviceImmediate medical attention is required. If symptoms persist, call a physician.
Eye contact
Immediately flush with plenty of water. After initial flushing, remove any contact lenses and continue flushing for at least 15 minutes. Keep eye wide open while rinsing. Call a physician immediately. If symptoms persist, call a physician.
Skin Contact
Wash off immediately with soap and plenty of water while removing all contaminated clothes and shoes. Immediate medical attention is required. Wash contaminated clothing before reuse. Wash off immediately with plenty of water. If skin irritation persists, call a physician.
Inhalation
Immediate medical attention is required Remove to fresh air If not breathing, give artificial respiration Avoid direct contact with skin. Use barrier to give mouth-to-mouth resuscitation
Artificial respiration and/or oxygen may be necessary Call a physician Move to fresh air in case of accidental inhalation of vapors If symptoms persist, call a physician
Ingestion
Artificial respiration and/or oxygen may be necessary Call a physician Move to fresh air in case of accidental inhalation of vapors If symptoms persist, call a physician
Do NOT induce vomiting. Call a physician or poison control center immediately. Never give anything by mouth to an unconscious person. Drink plenty of water. Clean mouth with wate and drink afterwards plenty of water. Call a physician.
Self-protection of the first aider
Use personal protective equipment as required. Avoid contact with skin, eyes or clothing.
Most important symptoms and effects, both acute and delayed
SymptomsNo information available.
Indication of any immediate medical attention and special treatment needed
Note to physiciansTreat symptomatically.
Suitable Extinguishing Media
Suitable Extinguishing MediaUse extinguishing measures that are appropriate to local circumstances and the surrounding environment.
Unsuitable Extinguishing Media
No information available.
Specific hazards arising from the chemical
Specific hazards arising from the chemicalNo information available.
Hazardous combustion products
Hydrogen sulfide. Carbon oxides.
Explosion data
Sensitivity to Mechanical ImpactNo information available.
Sensitivity to Static Discharge
No information available.
Protective equipment and precautions for firefighters
Protective equipment and precautions for firefightersWear self contained breathing apparatus for fire fighting if necessary. In the event of fire and/or explosion do not breathe fumes.
Personal precautions, protective equipment and emergency procedures
Personal precautionsUse personal protective equipment as required. Keep people away from and upwind of spill/leak. Evacuate personnel to safe areas.
Environmental precautions
Environmental precautionsPrevent further leakage or spillage if safe to do so. Prevent product from entering drains. Do not flush into surface water or sanitary sewer system. See Section 12 for additional
Ecological Information.
Ecological Information.
Methods and material for containment and cleaning up
Methods for containmentPrevent further leakage or spillage if safe to do so. Cover powder spill with plastic sheet or tarp to minimize spreading. Dike far ahead of liquid spill for later disposal.
Methods for cleaning up
Use personal protective equipment as required. Take up mechanically, placing in appropriate containers for disposal. Clean contaminated surface thoroughly. Cover powde spill with plastic sheet or tarp to minimize spreading and keep powder dry. Avoid creating dust. Soak up with inert absorbent material. Dam up. Pick up and transfer to properly labeled containers. Sweep up and shovel into suitable containers for disposal. Afte cleaning, flush away traces with water. Take precautionary measures against static discharges.
Precautions for safe handling
Advice on safe handlingUse personal protective equipment as required. Do not breathe dust/fume/gas/mist/vapors/spray. Avoid contact with skin, eyes or clothing. Wash contaminated clothing before reuse. Do not eat, drink or smoke when using this product.
Use with local exhaust ventilation. Noxious vapor/odor. Ensure adequate ventilation, especially in confined areas.
Use with local exhaust ventilation. Noxious vapor/odor. Ensure adequate ventilation, especially in confined areas.
Conditions for safe storage, including any incompatibilities
Storage ConditionsKeep container tightly closed in a dry and well-ventilated place. Keep out of the reach of children. Keep containers tightly closed in a cool, well-ventilated place. Keep in properly labeled containers. Protect from moisture. Store at 4 °C.
Incompatible materials
None known based on information supplied.
Control parameters
Exposure GuidelinesThis product, as supplied, does not contain any hazardous materials with occupational exposure limits established by the region specific regulatory bodies.
Appropriate engineering controls
Engineering ControlsEnsure adequate ventilation, especially in confined areas
Individual protection measures, such as personal protective equipment
Eye/face protectionTight sealing safety goggles. Face protection shield.
Skin and Body Protection
Wear protective gloves and protective clothing.
Respiratory protection
If exposure limits are exceeded or irritation is experienced, NIOSH/MSHA approved respiratory protection should be worn. Positive-pressure supplied air respirators may be required for high airborne contaminant concentrations. Respiratory protection must be provided in accordance with current local regulations.
General Hygiene Considerations
When using do not eat, drink or smoke. Regular cleaning of equipment, work area and clothing is recommended. Avoid contact with skin, eyes or clothing. Wash hands thoroughly after handling. Keep away from food, drink and animal feeding stuffs.
Information on basic physicochemical properties
- Physical StateSolid
- Appearancepowder
- Odorunpleasant May be unpleasant
- pHNo information available
- Melting point/freezing point41 °C
- Boiling point364.5 °C
- Flash point174.2 °C
- Liquid Density1.3 g/cm3
- Evaporation rateNo information available
- Upper flammability limitsNo information available
- Lower flammability limitNo information available
- Vapor pressure0 mmHg
- Vapor densityNo information available
- Specific gravityNo information available
- Water solubilitySoluble
- Solubility in other solventsNo information available
- Partition coefficient6.600
- Autoignition temperatureNo information available
- Decomposition temperatureNo information available
- Kinematic viscosityNo information available
- Explosive propertiesNo information available
- Oxidizing propertiesNo information available
- Density and/or relative density1.04 g/mL at 20 °C
- SolubilityH2O: 50 mg/mL, clear, colorless
- ColourWhite
Reactivity
Not applicable
Chemical stability
Stable under recommended storage conditions.
Possibility of Hazardous Reactions
None under normal processing.
Hazardous polymerization
No information available.
Conditions to avoid
Heat, flames and sparks. Exposure to air or moisture over prolonged periods.
Incompatible materials
Strong oxidizing agents.
Hazardous Decomposition Products
Hydrogen sulfide. Carbon oxides.
Information on likely routes of exposure
InhalationClassified based on available data. For more details, see section 2.
Eye contact
Classified based on available data. For more details, see section 2.
Skin Contact
Classified based on available data. For more details, see section 2.
Ingestion
Classified based on available data. For more details, see section 2.
Information on toxicological effects
SymptomsClassified based on available data. For more details, see section 2.
Delayed and immediate effects as well as chronic effects from short and long-term exposure
Chronic ToxicityAvoid repeated exposure.
Numerical measures of toxicity - Product Information
Unknown acute toxicityClassified based on available data. For more details, see section 2
Ecotoxicity
May cause long lasting harmful effects to aquatic life
100% of the mixture consists of components(s) of unknown hazards to the aquatic environment.
100% of the mixture consists of components(s) of unknown hazards to the aquatic environment.
Persistence and degradability
No information available.
Bioaccumulation
No information available.
Mobility
No information available.
Disposal of wastes
Disposal should be in accordance with applicable regional, national and local laws and regulations.
Contaminated packaging
Do not reuse container.
Other Information
Waste codes should be assigned by the user based on the application for which the product was used.
US EPA Waste Number
D001
DOT
UN/ID noUN3335
Hazard Class
9
Proper shipping name
Aviation regulated solid, n.o.s.
Description
UN3335, Aviation regulated solid, n.o.s., 9
Emergency Response Guide Number
171
IMDG
UN/ID noUN3335
Hazard Class
9
Proper shipping name
Aviation regulated solid, n.o.s.
Description
UN3335, Aviation regulated solid, n.o.s., 9
Special Provisions
960
IATA
UN/ID noUN3335
Hazard Class
9
Packing Group
III
Proper shipping name
Aviation regulated solid, n.o.s.
Description
UN3335, Aviation regulated solid, n.o.s. (DTT), 9, III
ERG Code
9A
International Inventories
All of the components in the product are on the following Inventory lists
Canada (DSL/NDSL) Europe (EINECS/ELINCS/NLP)
Chemical name TSCA DSL NDSL EINECS ELINCS ENCS IECSC KECL PICCS AICS
X - Listed
TSCA - United States Toxic Substances Control Act Section 8(b) Inventory
DSL/NDSL - Canadian Domestic Substances List/Non-Domestic Substances List
EINECS/ELINCS - European Inventory of Existing Chemical Substances/European List of Notified Chemical Substances
ENCS - Japan Existing and New Chemical Substances
IECSC - China Inventory of Existing Chemical Substances
KECL - Korean Existing and Evaluated Chemical Substances
PICCS - Philippines Inventory of Chemicals and Chemical Substances
DTT - X - X - - - - - -
Canada (DSL/NDSL) Europe (EINECS/ELINCS/NLP)
Chemical name TSCA DSL NDSL EINECS ELINCS ENCS IECSC KECL PICCS AICS
X - Listed
TSCA - United States Toxic Substances Control Act Section 8(b) Inventory
DSL/NDSL - Canadian Domestic Substances List/Non-Domestic Substances List
EINECS/ELINCS - European Inventory of Existing Chemical Substances/European List of Notified Chemical Substances
ENCS - Japan Existing and New Chemical Substances
IECSC - China Inventory of Existing Chemical Substances
KECL - Korean Existing and Evaluated Chemical Substances
PICCS - Philippines Inventory of Chemicals and Chemical Substances
DTT - X - X - - - - - -
US Federal Regulations
SARA 313
Section 313 of Title III of the Superfund Amendments and Reauthorization Act of 1986 (SARA). This product does not contain any chemicals which are subject to the reporting requirements of the Act and Title 40 of the Code of Federal Regulations, Part 372.
SARA 311/312 Hazard Categories
Acute health hazardYes
Chronic Health Hazard
No
Fire hazard
No
Sudden release of pressure hazard
No
Reactive hazard
No
CWA (Clean Water Act)
This product does not contain any substances regulated as pollutants pursuant to the Clean Water Act (40 CFR 122.21 and 40
CFR 122.42).
CFR 122.42).
US State Regulations
California Proposition 65
This product does not contain any Proposition 65 chemicals.
U.S. State Right-to-Know Regulations
This product does not contain any substances regulated by state right-to-know regulations
Abbreviations and acronyms
CAS: Chemical Abstracts Service
TWA: Time-Weighted Average
STEL: Short-Term Exposure Limit
LD50: Lethal Dose 50%
LC50: Lethal Concentration 50%
EC50: Effective Concentration 50%
PEL: Permissible Exposure Limit
TLV: Threshold Limit Value
IMDG: International Maritime Dangerous Goods Code
IATA: International Air Transport Association
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
DOT: US Department of Transportation
NFPA: National Fire Protection Association
NIOSH: National Institute for Occupational Safety and Health
OSHA: Occupational Safety and Health Administration
TWA: Time-Weighted Average
STEL: Short-Term Exposure Limit
LD50: Lethal Dose 50%
LC50: Lethal Concentration 50%
EC50: Effective Concentration 50%
PEL: Permissible Exposure Limit
TLV: Threshold Limit Value
IMDG: International Maritime Dangerous Goods Code
IATA: International Air Transport Association
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
DOT: US Department of Transportation
NFPA: National Fire Protection Association
NIOSH: National Institute for Occupational Safety and Health
OSHA: Occupational Safety and Health Administration
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.