Chemical Safety Data Sheet MSDS / SDS
3,5-DICHLOROPHENYLMAGNESIUM BROMIDE
Revision Date:2026-03-21Revision Number:1
Product identifier
- Product name: 3,5-DICHLOROPHENYLMAGNESIUM BROMIDE
- CBnumber: CB2448048
- CAS: 82297-90-3
- Synonyms: 5-DICHLOROPHENYLMAGNESIUM BROMIDE;bromo(3,5-dichlorophenyl)magnesium
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordDanger
P403+P235 Store in a well-ventilated place. Keep cool.
P370+P378 In case of fire: Use … for extinction.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
Hazard statements
H351 Suspected of causing cancer
H335 May cause respiratory irritation
H314 Causes severe skin burns and eye damage
H302 Harmful if swallowed
H225 Highly Flammable liquid and vapour
Substance
- Product name: 3,5-DICHLOROPHENYLMAGNESIUM BROMIDE
- Synonyms: 5-DICHLOROPHENYLMAGNESIUM BROMIDE;bromo(3,5-dichlorophenyl)magnesium
- CAS: 82297-90-3
- MF: C6H3BrCl2Mg
- MW: 250.2
General advice
First aiders need to protect themselves. Show this material safety data sheet to the doctor in attendance.
If inhaled
After inhalation: fresh air. Call in physician.
In case of skin contact
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Call a physician immediately.
In case of eye contact
After eye contact: rinse out with plenty of water. Immediately call in ophthalmologist. Remove contact lenses.
If swallowed
After swallowing: make victim drink water (two glasses at most), avoid vomiting (risk of perforation). Call a physician immediately. Do not attempt to neutralise.
Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2) and/or in section 11
Protection of first-aiders
For personal protection see section 8.
Notes to physician
No data available
Suitable extinguishing media
Carbon dioxide (CO2) Dry powder
Unsuitable extinguishing media
Water Foam
Specific hazards during fire fighting
Combustible. Pay attention to flashback. Vapors are heavier than air and may spread along floors. May not get in touch with: Water Development of hazardous combustion gases or vapours possible in the event of fire. Forms explosive mixtures with air at ambient temperatures.
Hazardous combustion products
Carbon oxides Hydrogen chloride gas Hydrogen bromide gas Magnesium oxide
Specific extinguishing methods
Remove container from danger zone and cool with water. Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.
Special protective equipment for fire-fighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.
NFPA 704
3
3
2
| HEALTH | 3 | Short exposure could cause serious temporary or moderate residual injury (e.g. liquid hydrogen, sulfuric acid, calcium hypochlorite, hexafluorosilicic acid) | |
| FIRE | 3 | Liquids and solids (including finely divided suspended solids) that can be ignited under almost all ambient temperature conditions . Liquids having a flash point below 22.8 °C (73 °F) and having a boiling point at or above 37.8 °C (100 °F) or having a flash point between 22.8 and 37.8 °C (73 and 100 °F). (e.g. gasoline, acetone) | |
| REACT | 2 | Undergoes violent chemical change at elevated temperatures and pressures, reacts violently with water, or may form explosive mixtures with water (e.g. white phosphorus, potassium, sodium) | |
| SPEC. HAZ. |
Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance contact. Ensure adequate ventilation. Keep away from heat and sources of ignition. Evacuate the danger area, observe emergency procedures, consult an expert. Advice for emergency responders: For personal protection see section 8.
Environmental precautions
Do not let product enter drains. Risk of explosion.
Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up carefully with liquid-absorbent material . Dispose of properly. Clean up affected area.
Handling
Advice on protection against fire and explosionKeep away from open flames, hot surfaces and sources of ignition. Take precautionary measures against static discharge.
Advice on safe handling
Work under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols. Keep workplace dry. Do not allow product to come into contact with water.
Avoidance of contact
Oxidizing agents Oxygen Acids Alcohols
Storage
Further information on storage conditionsKeep container tightly closed in a dry and wellventilated place. Keep away from heat and sources of ignition.
Materials to avoid
Never allow product to get in contact with water during storage.
Storage class
3, Flammable liquids
Recommended storage temperature
2 - 8 °C
Further information on storage stability
Handle and store under inert gas. Air and moisture sensitive. Dry residue is explosive. Test for peroxide formation periodically and before distillation.
Ingredients with workplace control parameters
Biological occupational exposure limits exposure ceases)
Engineering measures
No data available
Personal protective equipment
Respiratory protectionrequired when vapours/aerosols are generated.
Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Recommended Filter type
Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Filter type ABEK
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented.
Eye/face protection
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented.
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Tightly fitting safety goggles
Skin and body protection
Tightly fitting safety goggles
Flame retardant antistatic protective clothing.
Hand protection
Remarks
required
Hygiene measures
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.
Information on basic physicochemical properties
- Physical stateLiquid
- Particle characteristics Particle sizeNo data available
- Molecular weight250.20 g/mol
- Oxidizing propertiesnone
- Explosive propertiesNot classified as explosive.
- Flow timeNo data available
- Viscosity, kinematicNo data available
- Viscosity, dynamicNo data available
- Decomposition temperatureNo data available
- Autoignition temperatureNo data available
- Partition coefficient: n-octanol/waterNo data available
- Water solubilityNo data available
- Density0.972 g/cm3
- Relative density0.972 g/mL at 25 °C
- Relative vapor densityNo data available
- Vapor pressureNo data available
- Lower explosion limit / Lower flammability limitNo data available
- Upper explosion limit / Upper flammability limitNo data available
- Burning rateNo data available
- Flammability (liquids)No data available
- Flammability (solid, gas)No data available
- Evaporation rateNo data available
- Flash point-21.2 °C (1,013 hPa)
Method: DIN 51755 Part 1, closed cup - Boiling point/boiling range65 °C
- Melting point/ rangeNo data available
- pHNo data available
- Odor ThresholdNo data available
- OdorNo data available
- Colorbrown
- Appearanceliquid
Reactivity
Formation of peroxides possible. Vapors may form explosive mixture with air.
Chemical stability
sensitive to moisture
Possibility of hazardous reactions
No data available
Conditions to avoid
Warming. Moisture.
Incompatible materials
Oxidizing agents Oxygen Acids Alcohols
Hazardous decomposition products
Peroxides : In the event of fire: see section 5
11.1 Information on toxicological effects
Mixture Acute toxicityOral: No data available
Symptoms: mucosal irritations, Cough, Shortness of breath, Possible damages:, damage of respiratory tract
Dermal: No data available
Skin corrosion/irritation
Symptoms: mucosal irritations, Cough, Shortness of breath, Possible damages:, damage of respiratory tract
Dermal: No data available
Remarks: Mixture causes burns.
Serious eye damage/eye irritation
Remarks: Mixture causes serious eye damage.
Risk of blindness!
Respiratory or skin sensitization
Risk of blindness!
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
Classified based on available data. For more details, see section 2
Carcinogenicity
Evidence of a carcinogenic effect.
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Mixture may cause respiratory irritation.
Mixture may cause drowsiness or dizziness.
Specific target organ toxicity - repeated exposure
Mixture may cause drowsiness or dizziness.
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
11.2 Additional Information
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Other dangerous properties can not be excluded.
This substance should be handled with particular care.
Handle in accordance with good industrial hygiene and safety practice.
Components Tetrahydrofuran
Other dangerous properties can not be excluded.
This substance should be handled with particular care.
Handle in accordance with good industrial hygiene and safety practice.
Acute toxicity
LD50 Oral - Rat - male and female - 1,650 mg/kg
Remarks: (ECHA)
Symptoms: Irritation of mucous membranes
LC50 Inhalation - Rat - male and female - 6 h - > 14.7 mg/l - vapor (US-EPA)
LD50 Dermal - Rat - male and female - > 2,000 mg/kg (OECD Test Guideline 402)
Remarks: (ECHA)
Symptoms: Irritation of mucous membranes
LC50 Inhalation - Rat - male and female - 6 h - > 14.7 mg/l - vapor (US-EPA)
LD50 Dermal - Rat - male and female - > 2,000 mg/kg (OECD Test Guideline 402)
Skin corrosion/irritation
Skin - Rabbit
Result: No skin irritation - 72 h (Draize Test)
Remarks: Repeated or prolonged exposure may cause skin irritation and dermatitis, due to degreasing properties of the product.
Result: No skin irritation - 72 h (Draize Test)
Remarks: Repeated or prolonged exposure may cause skin irritation and dermatitis, due to degreasing properties of the product.
Serious eye damage/eye irritation
Eyes - Rabbit
Result: Causes serious eye irritation.
Remarks: (IUCLID)
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Result: Causes serious eye irritation.
Remarks: (IUCLID)
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Respiratory or skin sensitization
Local lymph node assay (LLNA) - Mouse
Result: negative (OECD Test Guideline 429)
Germ cell mutagenicity
Result: negative (OECD Test Guideline 429)
Test Type: Ames test
Test system: S. typhimurium
Result: negative
Test Type: In vitro mammalian cell gene mutation test
Test system: Chinese hamster ovary cells
Result: negative
Test Type: Chromosome aberration test in vitro
Test system: Chinese hamster ovary cells
Result: negative
Method: OECD Test Guideline 474
Species: Mouse - male and female - Red blood cells (erythrocytes)
Result: negative
Carcinogenicity
Test system: S. typhimurium
Result: negative
Test Type: In vitro mammalian cell gene mutation test
Test system: Chinese hamster ovary cells
Result: negative
Test Type: Chromosome aberration test in vitro
Test system: Chinese hamster ovary cells
Result: negative
Method: OECD Test Guideline 474
Species: Mouse - male and female - Red blood cells (erythrocytes)
Result: negative
Suspected of causing cancer.
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Inhalation - May cause respiratory irritation. - Central nervous system
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
May cause drowsiness or dizziness.
Acute oral toxicity - Irritation of mucous membranes
Specific target organ toxicity - repeated exposure Aspiration hazard
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
May cause drowsiness or dizziness.
Acute oral toxicity - Irritation of mucous membranes
Classified based on available data. For more details, see section 2
3,5-Dichlorophenylmagnesium bromide Acute toxicity
Oral: No data available
Inhalation: No data available
Dermal: No data available
Skin corrosion/irritation
Inhalation: No data available
Dermal: No data available
Remarks: No data available
Serious eye damage/eye irritation
Classified based on available data. For more details, see section 2
Respiratory or skin sensitization
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
Classified based on available data. For more details, see section 2
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
Ecotoxicity
Components:
Tetrahydrofuran:
Toxicity to fishLC50 (Pimephales promelas (fathead minnow)): 2,160 mg/l End point: mortality Exposure time: 96 h Test Type: flow-through test Analytical monitoring: yes Method: OECD Test Guideline 203
Toxicity to daphnia and other aquatic invertebrates
EC50 (Daphnia magna (Water flea)): 3,485 mg/l End point: mortality Exposure time: 48 h Test Type: static test Method: OECD Test Guideline 202
Toxicity to fish (Chronic toxicity)
NOEC (Pimephales promelas (fathead minnow)): 216 mg/l End point: Growth inhibition Exposure time: 33 d Test Type: flow-through test Analytical monitoring: yes Remarks: (ECHA)
Persistence and degradability
Components:
Tetrahydrofuran:
Biodegradabilityaerobic Inoculum: activated sludge Concentration: 2 mg/l Biochemical oxygen demand Result: Not readily biodegradable. Biodegradation: 39 % Exposure time: 28 d Method: OECD Test Guideline 301D
Bioaccumulative potential
Components:
Tetrahydrofuran:
Partition coefficient: noctanol/waterlog Pow: 0.45 (25 °C) Method: OECD Test Guideline 107 Remarks: Bioaccumulation is not expected.
Mobility in soil
No data available
Other adverse effects
Components:
Tetrahydrofuran:
Results of PBT and vPvB assessmentSubstance does not meet the criteria for PBT or vPvB according to Regulation (EC) No 1907/2006, Annex XIII.
Disposal methods
Waste from residuesOffer surplus and non-recyclable solutions to a licensed disposal company.
International Regulations
IATA-DGR
UN/ID No. : UN 2924
Proper shipping name : Flammable liquid, corrosive, n.o.s.
(Tetrahydrofuran, 3,5-Dichlorophenylmagnesium bromide)
Class : 3
Subsidiary risk : 8
Packing group : II
Labels : Class 3 - Flammable liquids, Class 8 - Corrosive substances
Packing instruction (cargo aircraft) : 363
Packing instruction (passenger aircraft) : 352
Proper shipping name : Flammable liquid, corrosive, n.o.s.
(Tetrahydrofuran, 3,5-Dichlorophenylmagnesium bromide)
Class : 3
Subsidiary risk : 8
Packing group : II
Labels : Class 3 - Flammable liquids, Class 8 - Corrosive substances
Packing instruction (cargo aircraft) : 363
Packing instruction (passenger aircraft) : 352
IMDG-Code
UN number : UN 2924
Proper shipping name : FLAMMABLE LIQUID, CORROSIVE, N.O.S.
(Tetrahydrofuran, 3,5-Dichlorophenylmagnesium bromide)
Class : 3
Subsidiary risk : 8
Packing group : II
Labels : 3 (8)
EmS Code : F-E, S-C
Marine pollutant : no
Proper shipping name : FLAMMABLE LIQUID, CORROSIVE, N.O.S.
(Tetrahydrofuran, 3,5-Dichlorophenylmagnesium bromide)
Class : 3
Subsidiary risk : 8
Packing group : II
Labels : 3 (8)
EmS Code : F-E, S-C
Marine pollutant : no
Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not applicable for product as supplied.
National regulation GB 6944/12268
UN number : UN 2924
Proper shipping name : FLAMMABLE LIQUID, CORROSIVE, N.O.S.
(Tetrahydrofuran, 3,5-Dichlorophenylmagnesium bromide)
Class : 3
Subsidiary risk : 8
Packing group : II
Labels : 3 (8)
National regulation GB 6944/12268
UN number : UN 2924
Proper shipping name : FLAMMABLE LIQUID, CORROSIVE, N.O.S.
(Tetrahydrofuran, 3,5-Dichlorophenylmagnesium bromide)
Class : 3
Subsidiary risk : 8
Packing group : II
Labels : 3 (8)
Special precautions for user
The transport classification(s) provided herein are for informational purposes only, and solely based upon the properties of the unpackaged material as it is described within this Safety Data Sheet. Transportation classifications may vary by mode of transportation, package sizes, and variations in regional or country regulations.
National regulatory information
Law on the Prevention and Control of Occupational Diseases
Regulations on Safety Management of Hazardous Chemicals
Catalogue of Hazardous Chemicals Identification of Major Hazard Installations for Hazardous Chemicals (GB 18218)
Listed
No. / Code Chemical name / Category Threshold quantity
W5.3 Flammable liquids 1,000 t
Hazardous Chemicals for Priority Management
Listed under SAWS
Regulation of Environmental Management on the First Import of Chemicals and the Import and Export of Toxic Chemicals
China Severely Restricted Toxic Chemicals for Import and Export
Not applicable
Full text of other abbreviations
ACGIHUSA. ACGIH Threshold Limit Values (TLV)
ACGIH BEI
ACGIH - Biological Exposure Indices (BEI)
GBZ 2.1-2007
Occupational exposure limits for hazardous agents in the workplace - Chemical hazardous agents.
ACGIH / TWA
8-hour, time-weighted average
ACGIH / STEL
Short-term exposure limit
GBZ 2.1-2007 / PC-TWA AIIC - Australian Invent Transport by Land of Bra bw - Body weight; CMR Standard of the German List (Canada); ECx - Conc associated with x% respo Chemical Substances (Jap response; ERG - Emerge GLP - Good Laboratory P cer; IATA - International Construction and Equipm Half maximal inhibitory c tion; IECSC - Inventory o tional Maritime Dangerou Industrial Safety and H Standardization; KECI - K tration to 50 % of a test (Median Lethal Dose); MA lution from Ships; n.o.s. No Observed (Adverse) E fect Level; NOELR - No Norm; NTP - National Toxi icals; OECD - Organizatio fice of Chemical Safety a and Toxic substance; PIC stances; (Q)SAR - (Quant (EC) No 1907/2006 of th Registration, Evaluation, Accelerating Decompositi Chemical Substance Inve Thailand Existing Chemica States); UN - United Nat Transport of Dangerous WHMIS - Workplace Hazar
Permissible concentration - time weighted average ry of Industrial Chemicals
ANTT - National Agency for il
ASTM - American Society for the Testing of Materials
- Carcinogen, Mutagen or Reproductive Toxicant
DIN nstitute for Standardisation
DSL - Domestic Substances ntration associated with x% response
ELx - Loading rate se
EmS - Emergency Schedule
ENCS - Existing and New n)
ErCx - Concentration associated with x% growth rate cy Response Guide
GHS - Globally Harmonized System
actice
IARC - International Agency for Research on Canir Transport Association
IBC - International Code for the nt of Ships carrying Dangerous Chemicals in Bulk
IC50 ncentration
ICAO - International Civil Aviation Organiza- Existing Chemical Substances in China
IMDG - Interna- Goods
IMO - International Maritime Organization
ISHL alth Law (Japan)
ISO - International Organisation for rea Existing Chemicals Inventory
LC50 - Lethal Concenopulation
LD50 - Lethal Dose to 50% of a test population POL - International Convention for the Prevention of Pol- Not Otherwise Specified
Nch - Chilean Norm
NO(A)EC fect Concentration
NO(A)EL - No Observed (Adverse) Efbservable Effect Loading Rate
NOM - Official Mexican ology Program
NZIoC - New Zealand Inventory of Chemfor Economic Co-operation and Development
OPPTS - Ofd Pollution Prevention
PBT - Persistent, Bioaccumulative S - Philippines Inventory of Chemicals and Chemical Subtative) Structure Activity Relationship
REACH - Regulation European Parliament and of the Council concerning the uthorisation and Restriction of Chemicals
SADT - Selfn Temperature
SDS - Safety Data Sheet
TCSI - Taiwan tory
TDG - Transportation of Dangerous Goods
TECI s Inventory
TSCA - Toxic Substances Control Act (United ons
UNRTDG - United Nations Recommendations on the oods
vPvB - Very Persistent and Very Bioaccumulative
ous Materials Information System
ANTT - National Agency for il
ASTM - American Society for the Testing of Materials
- Carcinogen, Mutagen or Reproductive Toxicant
DIN nstitute for Standardisation
DSL - Domestic Substances ntration associated with x% response
ELx - Loading rate se
EmS - Emergency Schedule
ENCS - Existing and New n)
ErCx - Concentration associated with x% growth rate cy Response Guide
GHS - Globally Harmonized System
actice
IARC - International Agency for Research on Canir Transport Association
IBC - International Code for the nt of Ships carrying Dangerous Chemicals in Bulk
IC50 ncentration
ICAO - International Civil Aviation Organiza- Existing Chemical Substances in China
IMDG - Interna- Goods
IMO - International Maritime Organization
ISHL alth Law (Japan)
ISO - International Organisation for rea Existing Chemicals Inventory
LC50 - Lethal Concenopulation
LD50 - Lethal Dose to 50% of a test population POL - International Convention for the Prevention of Pol- Not Otherwise Specified
Nch - Chilean Norm
NO(A)EC fect Concentration
NO(A)EL - No Observed (Adverse) Efbservable Effect Loading Rate
NOM - Official Mexican ology Program
NZIoC - New Zealand Inventory of Chemfor Economic Co-operation and Development
OPPTS - Ofd Pollution Prevention
PBT - Persistent, Bioaccumulative S - Philippines Inventory of Chemicals and Chemical Subtative) Structure Activity Relationship
REACH - Regulation European Parliament and of the Council concerning the uthorisation and Restriction of Chemicals
SADT - Selfn Temperature
SDS - Safety Data Sheet
TCSI - Taiwan tory
TDG - Transportation of Dangerous Goods
TECI s Inventory
TSCA - Toxic Substances Control Act (United ons
UNRTDG - United Nations Recommendations on the oods
vPvB - Very Persistent and Very Bioaccumulative
ous Materials Information System
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.
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