Chemical Safety Data Sheet MSDS / SDS

HOAt

Revision Date:2026-03-21Revision Number:1

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

  • Product name: HOAt
  • CBnumber: CB3256884
  • CAS: 39968-33-7
  • EINECS Number: 609-760-3
  • Synonyms: 1-Hydroxy-7-azabenzotriazole;3H-[1,2,3]-TRIAZOLO[4,5-B]PYRIDIN-3-OL

Relevant identified uses of the substance or mixture and uses advised against

  • Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
  • Uses advised against: none

Company Identification

  • Company: Chemicalbook
  • Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
  • Telephone: 010-86108875

SECTION 2: Hazards identification

GHS Label elements, including precautionary statements

  • Symbol(GHS)
  • Signal wordWarning
Precautionary statements
P401 Store …
P374 Fight fire with normal precautions from a reasonable distance.
P373 DO NOT fight fire when fire reaches explosives.
P372 Explosion risk in case of fire.
P370+P380 in case of fire: Evacuate area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P250 Do not subject to grinding/shock/…/friction.
P240 Ground/bond container and receiving equipment.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P501 Dispose of contents/container to..…
P330 Rinse mouth.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P270 Do not eat, drink or smoke when using this product.
P264 Wash skin thouroughly after handling.
P362 Take off contaminated clothing and wash before reuse.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P321 Specific treatment (see … on this label).
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P264 Wash skin thouroughly after handling.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P264 Wash skin thouroughly after handling.
P501 Dispose of contents/container to..…
Hazard statements
H315 Causes skin irritation
H319 Causes serious eye irritation
H204 Fire or projection hazard
H302 Harmful if swallowed

SECTION 3: Composition/information on ingredients

Substance

  • Product name: HOAt
  • Synonyms: 1-Hydroxy-7-azabenzotriazole;3H-[1,2,3]-TRIAZOLO[4,5-B]PYRIDIN-3-OL
  • CAS: 39968-33-7
  • EC number: 609-760-3
  • MF: C5H4N4O
  • MW: 136.11

SECTION 4: First aid measures

General advice

Show this safety data sheet to the doctor in attendance.

If inhaled

After inhalation: fresh air. Immediately call in physician. If breathing stops: immediately apply artificial respiration, if necessary also oxygen.

In case of skin contact

In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Consult a physician.

In case of eye contact

After eye contact: rinse out with plenty of water. Call in ophthalmologist. Remove contact lenses.

If swallowed

After swallowing: immediately make victim drink water (two glasses at most). Consult a physician.

Most important symptoms and effects, both acute and delayed

The most important known symptoms and effects are described in the labelling (see section 2) and/or in section 11

Protection of first-aiders

For personal protection see section 8.

Notes to physician

No data available

SECTION 5: Firefighting measures

Suitable extinguishing media

Foam Carbon dioxide (CO2) Dry powder

Unsuitable extinguishing media

For this substance/mixture no limitations of extinguishing agents are given.

Specific hazards during fire fighting

Combustible. Vapours are heavier than air and may spread along floors. Forms explosive mixtures with air at elevated temperatures. Development of hazardous combustion gases or vapours possible in the event of fire.

Hazardous combustion products

Carbon oxides Nitrogen oxides (NOx)

Specific extinguishing methods

Remove container from danger zone and cool with water. Suppress (knock down) gases/vapours/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.

Special protective equipment for fire-fighters

Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.

SECTION 6: Accidental release measures

Personal precautions, protective equipment and emergency procedures

Advice for non-emergency personnel: Do not breathe vapours, aerosols. Avoid substance contact. Ensure adequate ventilation. Keep away from heat and sources of ignition. Evacuate the danger area, observe emergency procedures, consult an expert. Advice for emergency responders: For personal protection see section 8.

Environmental precautions

Do not let product enter drains. Risk of explosion.

Methods and materials for containment and cleaning up

Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up carefully with liquid-absorbent material . Dispose of properly. Clean up affected area.

SECTION 7: Handling and storage

Handling

Advice on protection against fire and explosion
Keep away from open flames, hot surfaces and sources of ignition. Take precautionary measures against static discharge.
Advice on safe handling
Work under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols.
Avoidance of contact
Strong oxidizing agents

Storage

Further information on storage conditions
Keep container tightly closed in a dry and wellventilated place. Keep away from heat and sources of ignition. Keep locked up or in an area accessible only to qualified or authorised persons.
Storage class
3, Flammable liquids
Recommended storage temperature
Recommended storage temperature see product label.

SECTION 8: Exposure controls/personal protection

Ingredients with workplace control parameters

2007
Biological occupational exposure limits

Engineering measures

No data available

Personal protective equipment

Respiratory protection
required when vapours/aerosols are generated.
Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Recommended Filter type
Filter type ABEK
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented.
Eye/face protection
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Safety glasses
Skin and body protection
Flame retardant antistatic protective clothing.
Hand protection
Material
butyl-rubber
Break through time
480 min
Glove thickness
0.3 mm
Protective index
Full contact
Manufacturer
Butoject® (KCL 897 / Aldrich Z677647, Size M)
Material
Nature latex/chloroprene
Break through time
60 min
Glove thickness
0.6 mm
Protective index
Splash contact
Manufacturer
Lapren® (KCL 706 / Aldrich Z677558, Size M)
Manufacturer
data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail sales@kcl.de, test method: EN374
Remarks
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it.
If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.
Hygiene measures
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.

SECTION 9: Physical and chemical properties

Information on basic physicochemical properties

  • Physical statePowder
  • Solubility>6.8mg/mL in DMSO
  • Molecular weight136.11 g/mol
  • Oxidizing propertiesnone
  • Explosive propertiesNot classified as explosive.
  • Flow timeNo data available
  • Viscosity, kinematicNo data available
  • Viscosity, dynamicNo data available
  • Decomposition temperatureNo data available
  • Autoignition temperatureNo data available
  • Partition coefficient: n-octanol/waterNo data available
  • Water solubilityNo data available
  • Density0.973 g/cm3 (20 °C)
  • Relative density0.973 g/mL at 20 °C
  • Relative vapor densityNo data available
  • Vapor pressureNo data available
  • Lower explosion limit / Lower flammability limitNo data available
  • Upper explosion limit / Upper flammability limitNo data available
  • Burning rateNo data available
  • Flammability (liquids)No data available
  • Flammability (solid, gas)No data available
  • Evaporation rateNo data available
  • Flash point58 °C
    Method: closed cup
  • Boiling point/boiling range250.36°C (rough estimate)
  • Melting point/ rangeNo data available
  • pHNo data available
  • Odor ThresholdNo data available
  • OdorNo data available
  • ColorWhite to yellow
  • Appearanceliquid
  • Particle characteristics Particle sizeNo data available

SECTION 10: Stability and reactivity

Reactivity

Vapour/air-mixtures are explosive at intense warming.

Chemical stability

The product is chemically stable under standard ambient conditions (room temperature) .

Possibility of hazardous reactions

No data available

Conditions to avoid

Heating.

Incompatible materials

Strong oxidizing agents

Hazardous decomposition products

In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Mixture Acute toxicity
Oral: No data available
Acute toxicity estimate Oral - 3,230 mg/kg (Calculation method)
Acute toxicity estimate Inhalation - 4 h - 11.91 mg/l - vapour(Calculation method)
Symptoms: Possible symptoms:, mucosal irritations
Acute toxicity estimate Dermal - 1,610 mg/kg (Calculation method)
Skin corrosion/irritation
Classified based on available data. For more details, see section 2
Serious eye damage/eye irritation
Remarks: Mixture causes serious eye irritation.
Respiratory or skin sensitization
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
Classified based on available data. For more details, see section 2
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2

11.2 Additional Information

Warning: intolerance for alcohol can occur up to 4 days after dimethylformamide exposure. N,N-dimethylformamide is considered to be a potent liver toxin., Vomit- ing, Diarrhoea, Abdominal pain, To the best of our knowledge, the chemical, physi- cal, and toxicological properties have not been thoroughly investigated.
Components N,N-dimethylformamide
Acute toxicity
LD50 Oral - Rat - male and female - 3,010 mg/kg (OECD Test Guideline 401)
Acute toxicity estimate Inhalation - 4 h - 11.1 mg/l - vapour (Expert judgement)
Remarks: (Regulation (EC) No 1272/2008, Annex VI)
LD50 Dermal - Rabbit - 1,500 mg/kg
Remarks: (Regulation (EC) No 1272/2008, Annex VI) (IUCLID)
Skin corrosion/irritation
Skin - Rabbit
Result: No skin irritation - 20 h
Remarks: (ECHA)
Serious eye damage/eye irritation
Eyes - Rabbit
Result: Irritating to eyes.
(OECD Test Guideline 405)
Remarks: (Regulation (EC) No 1272/2008, Annex VI)
Respiratory or skin sensitization
Local lymph node assay (LLNA) - Mouse
Result: negative (OECD Test Guideline 406)
Germ cell mutagenicity
Test Type: sister chromatid exchange assay
Test system: Chinese hamster ovary cells
Result: negative
Remarks: (ECHA)
Test Type: unscheduled DNA synthesis assay
Test system: human diploid fibroblasts
Result: negative
Remarks: (ECHA)
Test Type: Ames test
Test system: Salmonella typhimurium
Result: negative
Remarks: (ECHA)
Species: Mouse - male - Bone marrow
Result: negative
Remarks: (ECHA)
Species: Rat - male
Result: negative
Remarks: (ECHA)
Species: Mouse - male
Result: negative
Remarks: (ECHA)
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
May damage the unborn child.
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure Aspiration hazard
Classified based on available data. For more details, see section 2
1-Hydroxy-7-azabenzotriazole Acute toxicity
LD50 Oral - Rat - > 2,000 mg/kg
Remarks: (RTECS)
Inhalation: Irritating to respiratory system.
Dermal: No data available
Skin corrosion/irritation
Remarks: Causes skin irritation.
Serious eye damage/eye irritation
Remarks: Causes serious eye irritation.
Respiratory or skin sensitization
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
Classified based on available data. For more details, see section 2
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Inhalation - May cause respiratory irritation.
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2

SECTION 12: Ecological information

Ecotoxicity

Components:

N,N-dimethylformamide:

Toxicity to fish
LC50 (Lepomis macrochirus (Bluegill sunfish)): 7,100 mg/l End point: mortality Exposure time: 96 h Test Type: flow-through test Analytical monitoring: yes Method: US-EPA
Toxicity to daphnia and other aquatic invertebrates
EC50 (Daphnia magna (Water flea)): 13,100 mg/l End point: Immobilization Exposure time: 48 h Test Type: static test Method: OECD Test Guideline 202
Toxicity to algae/aquatic plants
ErC50 (Desmodesmus subspicatus (green algae)): > 1,000 mg/l Exposure time: 72 h Test Type: static test Method: DIN 38412
Toxicity to daphnia and other aquatic invertebrates (Chronic toxicity)
NOEC (Daphnia magna (Water flea)): 1,500 mg/l End point: reproduction rate Exposure time: 21 d Test Type: semi-static test Remarks: (ECHA)
Toxicity to microorganisms
EC50 (Vibrio fischeri): 12,300 - 17,500 mg/l End point: Growth rate Exposure time: 5 min Test Type: static test Remarks: (ECHA)

Persistence and degradability

Components:

N,N-dimethylformamide:

Biodegradability
aerobic Concentration: 20 mg/l Result: Readily biodegradable. Biodegradation: 100 % Exposure time: 21 d Method: OECD Test Guideline 301E
Biochemical Oxygen Demand (BOD)
900 mg/g Incubation time: 5 d Remarks: (Lit.)
ThOD
1,863 mg/g Remarks: (Lit.)
Stability in water
Degradation half life: ca. 50 d Remarks: reaction with hydroxyl radicals (calculated) (Lit.)

Bioaccumulative potential

Components:

N,N-dimethylformamide:

Bioaccumulation
Species: Cyprinus carpio (Carp) Bioconcentration factor (BCF): 0.3 - 1.2 Exposure time: 56 d Temperature: 25 °C Concentration: 0.002 mg/l Method: OECD Test Guideline 305C Remarks: Does not significantly accumulate in organisms.
Partition coefficient: noctanol/water
log Pow: -0.85 (25 °C) Method: OECD Test Guideline 107 Remarks: Bioaccumulation is not expected.

Mobility in soil

No data available

Other adverse effects

No data available

SECTION 13: Disposal considerations

Disposal methods

Waste from residues
Offer surplus and non-recyclable solutions to a li- censed disposal company.

SECTION 14: Transport information

International Regulations

IATA-DGR

UN/ID No. : UN 1993
Proper shipping name : Flammable liquid, n.o.s.
(N,N-dimethylformamide)
Class : 3
Packing group : III
Labels : Class 3 - Flammable liquids
Packing instruction (cargo aircraft) : 366
Packing instruction (passenger aircraft) : 355

IMDG-Code

UN number : UN 1993
Proper shipping name : FLAMMABLE LIQUID, N.O.S.
(N,N-dimethylformamide)
Class : 3
Packing group : III
Labels : 3
EmS Code : F-E, S-E
Marine pollutant : no

Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

Not applicable for product as supplied.

National Regulations

JT/T 617

UN number : UN 1993
Proper shipping name : FLAMMABLE LIQUID, N.O.S.
(N,N-dimethylformamide)
Class : 3
Packing group : III
Labels : 3
Environmentally hazardous : no

Special precautions for user

The transport classification(s) provided herein are for informational purposes only, and solely based upon the properties of the unpackaged material as it is described within this Safety Data Sheet. Transportation classifications may vary by mode of transportation, package sizes, and variations in regional or country regulations.

SECTION 15: Regulatory information

National regulatory information

Law on the Prevention and Control of Occupational Diseases

Regulations on Safety Management of Hazardous Chemicals

Catalogue of Hazardous Chemicals

Listed

Identification of Major Hazard Installations for Hazardous Chemicals (GB 18218)

No. / Code Chemical name / Category Threshold quantity

W5.4 Flammable liquids 5,000 t

Hazardous Chemicals for Priority Management

Not listed under SAWS

Catalogue of Specially Controlled Hazardous

Not listed Chemicals

List of Explosive Precursors

Not listed

Regulations on Labour Protection in Workplaces where Toxic Substances are Used

Catalogue of Highly Toxic Chemicals

Not listed

Regulation of Environmental Management on the First Import of Chemicals and the Import and Export of Toxic Chemicals

China Severely Restricted Toxic Chemicals for Import and Export

Not listed

Regulation on the Administration of Precursor Chemicals

Catalogue and Classification of Precursor Chemicals

Not listed

Regulations on the Administration of Controlled Chemicals

List of Controlled Chemicals

Not listed

Regulations of Ozone Depleting Substances Management

List of Controlled Ozone Depleting Substances

Not listed

List of Controlled Ozone Depleting Substances Import and Export

Not listed

Environmental Protection Law

List of Priority Controlled Chemicals

Not listed

List of Key Controlled New Pollutants

Not listed

SECTION 16: Other information

Full text of other abbreviations

ACGIH
USA. ACGIH Threshold Limit Values (TLV)
ACGIH BEI
ACGIH - Biological Exposure Indices (BEI)
CN BEI
China. Biological Occupational Exposure Indices
GBZ 2.1-2007
Occupational exposure limits for hazardous agents in the workplace - Chemical hazardous agents.
ACGIH / TWA
8-hour, time-weighted average
GBZ 2.1-2007 / PC-TWA AIIC - Australian Invent Transport by Land of Bra bw - Body weight; CMR Standard of the German List (Canada); ECx - Conc associated with x% respo Chemical Substances (Jap response; ERG - Emerge GLP - Good Laboratory P cer; IATA - International Construction and Equipm Half maximal inhibitory c tion; IECSC - Inventory o tional Maritime Dangerou Industrial Safety and H Standardisation; KECI - K tration to 50 % of a test (Median Lethal Dose); MA lution from Ships; MERC of Dangerous Goods; n.o. - No Observed (Adverse) fect Level; NOELR - No Norm; NTP - National Toxi icals; OECD - Organisatio fice of Chemical Safety a and Toxic substance; PIC stances; (Q)SAR - (Quant (EC) No 1907/2006 of th Registration, Evaluation, Accelerating Decompositi Chemical Substance Inve Thailand Existing Chemica States); UN - United Nat Transport of Dangerous WHMIS - Workplace Hazar
Permissible concentration - time weighted average ry of Industrial Chemicals
ANTT - National Agency for il
ASTM - American Society for the Testing of Materials
- Carcinogen, Mutagen or Reproductive Toxicant
DIN nstitute for Standardisation
DSL - Domestic Substances ntration associated with x% response
ELx - Loading rate se
EmS - Emergency Schedule
ENCS - Existing and New n)
ErCx - Concentration associated with x% growth rate cy Response Guide
GHS - Globally Harmonised System
actice
IARC - International Agency for Research on Canir Transport Association
IBC - International Code for the nt of Ships carrying Dangerous Chemicals in Bulk
IC50 ncentration
ICAO - International Civil Aviation Organiza- Existing Chemical Substances in China
IMDG - Interna- Goods
IMO - International Maritime Organisation
ISHL alth Law (Japan)
ISO - International Organisation for rea Existing Chemicals Inventory
LC50 - Lethal Concenopulation
LD50 - Lethal Dose to 50% of a test population POL - International Convention for the Prevention of Pol- SUR - The Agreement for the Facilitation of the Transport . - Not Otherwise Specified
Nch - Chilean Norm
NO(A)EC ffect Concentration
NO(A)EL - No Observed (Adverse) Efbservable Effect Loading Rate
NOM - Official Mexican ology Program
NZIoC - New Zealand Inventory of Chemfor Economic Co-operation and Development
OPPTS - Ofd Pollution Prevention
PBT - Persistent, Bioaccumulative S - Philippines Inventory of Chemicals and Chemical Subtative) Structure Activity Relationship
REACH - Regulation European Parliament and of the Council concerning the uthorisation and Restriction of Chemicals
SADT - Selfn Temperature
SDS - Safety Data Sheet
TCSI - Taiwan tory
TDG - Transportation of Dangerous Goods
TECI s Inventory
TSCA - Toxic Substances Control Act (United ons
UNRTDG - United Nations Recommendations on the oods
vPvB - Very Persistent and Very Bioaccumulative
ous Materials Information System
Disclaimer:

The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.

Recommended Products
HATU SDS 5-Methyl-1H-benzotriazole SDS 1,2,4-Triazole SDS 1-Hydroxybenzotriazole SDS HOAt SDS 1,2,3-1H-Triazole SDS 2-(7-Azabenzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate SDS (3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate SDS 7-Azabenzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate SDS CHLOROPHOSPHONAZO III SDS