11.1 Information on toxicological effects
Mixture Acute toxicity
Oral: No data available
Acute toxicity estimate Oral - 3,230 mg/kg (Calculation method)
Acute toxicity estimate Inhalation - 4 h - 11.91 mg/l - vapour(Calculation method)
Symptoms: Possible symptoms:, mucosal irritations
Acute toxicity estimate Dermal - 1,610 mg/kg (Calculation method)
Skin corrosion/irritation
Classified based on available data. For more details, see section 2
Serious eye damage/eye irritation
Remarks: Mixture causes serious eye irritation.
Respiratory or skin sensitization
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
Classified based on available data. For more details, see section 2
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
11.2 Additional Information
Warning: intolerance for alcohol can occur up to 4 days after dimethylformamide exposure. N,N-dimethylformamide is considered to be a potent liver toxin., Vomit- ing, Diarrhoea, Abdominal pain, To the best of our knowledge, the chemical, physi- cal, and toxicological properties have not been thoroughly investigated.
Components N,N-dimethylformamide
Acute toxicity
LD50 Oral - Rat - male and female - 3,010 mg/kg (OECD Test Guideline 401)
Acute toxicity estimate Inhalation - 4 h - 11.1 mg/l - vapour (Expert judgement)
Remarks: (Regulation (EC) No 1272/2008, Annex VI)
LD50 Dermal - Rabbit - 1,500 mg/kg
Remarks: (Regulation (EC) No 1272/2008, Annex VI) (IUCLID)
Skin corrosion/irritation
Skin - Rabbit
Result: No skin irritation - 20 h
Remarks: (ECHA)
Serious eye damage/eye irritation
Eyes - Rabbit
Result: Irritating to eyes.
(OECD Test Guideline 405)
Remarks: (Regulation (EC) No 1272/2008, Annex VI)
Respiratory or skin sensitization
Local lymph node assay (LLNA) - Mouse
Result: negative (OECD Test Guideline 406)
Germ cell mutagenicity
Test Type: sister chromatid exchange assay
Test system: Chinese hamster ovary cells
Result: negative
Remarks: (ECHA)
Test Type: unscheduled DNA synthesis assay
Test system: human diploid fibroblasts
Result: negative
Remarks: (ECHA)
Test Type: Ames test
Test system: Salmonella typhimurium
Result: negative
Remarks: (ECHA)
Species: Mouse - male - Bone marrow
Result: negative
Remarks: (ECHA)
Species: Rat - male
Result: negative
Remarks: (ECHA)
Species: Mouse - male
Result: negative
Remarks: (ECHA)
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
May damage the unborn child.
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure Aspiration hazard
Classified based on available data. For more details, see section 2
1-Hydroxy-7-azabenzotriazole Acute toxicity
LD50 Oral - Rat - > 2,000 mg/kg
Remarks: (RTECS)
Inhalation: Irritating to respiratory system.
Dermal: No data available
Skin corrosion/irritation
Remarks: Causes skin irritation.
Serious eye damage/eye irritation
Remarks: Causes serious eye irritation.
Respiratory or skin sensitization
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
Classified based on available data. For more details, see section 2
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Inhalation - May cause respiratory irritation.
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2