Chemical Safety Data Sheet MSDS / SDS
7-Epitaxol
Revision Date:2026-03-20Revision Number:1
Product identifier
- Product name: 7-Epitaxol
- CBnumber: CB11468941
- CAS: 105454-04-4
- Synonyms: Epitaxol;EPITAXOL, 7-
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordDanger
P501 Dispose of contents/container to..…
P314 Get medical advice/attention if you feel unwell.
P270 Do not eat, drink or smoke when using this product.
P264 Wash skin thouroughly after handling.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P501 Dispose of contents/container to..…
P405 Store locked up.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P281 Use personal protective equipment as required.
P202 Do not handle until all safety precautions have been read and understood.
P201 Obtain special instructions before use.
P501 Dispose of contents/container to..…
P405 Store locked up.
P330 Rinse mouth.
P321 Specific treatment (see … on this label).
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P270 Do not eat, drink or smoke when using this product.
P264 Wash skin thouroughly after handling.
Hazard statements
H301 Toxic if swalloed
H340 May cause genetic defects
H351 Suspected of causing cancer
H372 Causes damage to organs through prolonged or repeated exposure
H360 May damage fertility or the unborn child
Substance
- Product name: 7-Epitaxol
- Synonyms: Epitaxol;EPITAXOL, 7-
- CAS: 105454-04-4
- MF: C47H51NO14
- MW: 853.91
Description of first aid measures
General information
Immediately remove any clothing soiled by the product.
Symptoms of poisoning may even occur after several hours; therefore medical observation for at least 48 hours after the accident.
In case of irregular breathing or respiratory arrest provide artificial respiration.
Symptoms of poisoning may even occur after several hours; therefore medical observation for at least 48 hours after the accident.
In case of irregular breathing or respiratory arrest provide artificial respiration.
After inhalation
In case of unconsciousness place patient stably in side position for transportation.
After skin contact
Immediately wash with water and soap and rinse thoroughly.
After eye contact
Rinse opened eye for several minutes under running water. Then consult a doctor.
After swallowing
Do not induce vomiting; immediately call for medical help.
Information for doctor
Most important symptoms and effects, both acute and delayed
No further relevant information available.
Indication of any immediate medical attention and special treatment needed
No further relevant information available.
Extinguishing media
Suitable extinguishing agents
Use fire fighting measures that suit the environment.
A solid water stream may be inefficient.
A solid water stream may be inefficient.
Special hazards arising from the substance or mixture
No further relevant information available.
Advice for firefighters
Protective equipment
No special measures required.
NFPA 704
2
0
0
| HEALTH | 2 | Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury (e.g. diethyl ether, ammonium phosphate, iodine) | |
| FIRE | 0 | Materials that will not burn under typical fire conditions, including intrinsically noncombustible materials such as concrete, stone, and sand. Materials that will not burn in air when exposed to a temperature of 820 °C (1,500 °F) for a period of 5 minutes.(e.g. Carbon tetrachloride) | |
| REACT | 0 | Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2) | |
| SPEC. HAZ. |
Personal precautions, protective equipment and emergency procedures
Not required.
Environmental precautions
Do not allow to enter sewers/ surface or ground water.
Methods and material for containment and cleaning up
Dispose contaminated material as waste according to section 13.
Ensure adequate ventilation.
Ensure adequate ventilation.
Protective Action Criteria for Chemicals
PAC-1
Substance is not listed.
PAC-2
Substance is not listed.
PAC-3
Substance is not listed.
Reference to other sections
See Section 7 for information on safe handling.
See Section 8 for information on personal protection equipment.
See Section 13 for disposal information.
See Section 8 for information on personal protection equipment.
See Section 13 for disposal information.
Handling
Precautions for safe handling
Thorough dedusting.
Information about protection against explosions and fires
No special measures required.
Conditions for safe storage, including any incompatibilities
Keep container tightly closed.
Store in accordance with information listed on the product insert.
Store in accordance with information listed on the product insert.
Storage
Store in accordance with information listed on the product insert.
Requirements to be met by storerooms and receptacles
No special requirements.
Information about storage in one common storage facility
Not required.
Further information about storage conditions
None.
Specific end use(s)
No further relevant information available.
Additional information about design of technical systems
No further data; see section 7.
Control parameters
Components with limit values that require monitoring at the workplace
Not required.
Additional information
The lists that were valid during the creation were used as basis.
Exposure controls
Personal protective equipment
General protective and hygienic measures
Keep away from foodstuffs, beverages and feed.
Immediately remove all soiled and contaminated clothing.
Wash hands before breaks and at the end of work.
Store protective clothing separately.
Immediately remove all soiled and contaminated clothing.
Wash hands before breaks and at the end of work.
Store protective clothing separately.
Breathing equipment
In case of brief exposure or low pollution use respiratory filter device. In case of intensive or longer exposure use respiratory protective device that is independent of circulating air.
Protection of hands
Protective gloves
The glove material has to be impermeable and resistant to the product/ the substance/ the preparation.
Due to missing tests no recommendation to the glove material can be given for the product/ the preparation/ the chemical mixture.
Selection of the glove material on consideration of the penetration times, rates of diffusion and the degradation
The glove material has to be impermeable and resistant to the product/ the substance/ the preparation.
Due to missing tests no recommendation to the glove material can be given for the product/ the preparation/ the chemical mixture.
Selection of the glove material on consideration of the penetration times, rates of diffusion and the degradation
Material of gloves
The selection of the suitable gloves does not only depend on the material, but also on further marks of quality and varies from manufacturer to manufacturer.
Penetration time of glove material
The exact break through time has to be found out by the manufacturer of the protective gloves and has to be observed.
Eye protection
Tightly sealed goggles
Information on basic physicochemical properties
- Other informationNo information available
- SOLUBILITYDMF: 25 mg/ml; DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml; DMSO 10 mg/ml; Ethanol: 5 mg/ml
- KinematicNot applicable.
- DynamicNot applicable.
- Partition coefficient (n-octanol/water)Not determined.
- WaterNot determined.
- Solubility in / Miscibility withDMF: 25 mg/ml; DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml; DMSO: 10 mg/ml; Ethanol: 5 mg/ml
- Evaporation RateNot applicable.
- Vapor DensityNot applicable.
- Relative Density1.39±0.1 g/cm3 (20 ºC 760 Torr)
- Density1.39±0.1 g/cm3 (20 ºC 760 Torr)
- Vapor PressureNot applicable.
- Explosion limitsLower: Not determined.
Upper: Not determined. - Danger of explosionProduct does not present an explosion hazard.
- Ignition temperatureNot determined.
- Decomposition temperatureNot determined.
- Flammability (solid,gas)Product is not flammable.
- Flash pointNot applicable.
- Boiling point/Boiling range957.1±65.0 °C(Predicted)
- Melting point/Melting rangeUndetermined.
- pHNot applicable.
- Odor ThresholdNot determined.
- Molecular Weight853.9 g/mol
- Structural FormulaC47H51NO14
- OdorCharacteristic
- ColorWhite to off-white
- Physical StateSolid
Reactivity
No further relevant information available.
Chemical stability
Thermal decomposition / conditions to be avoided
No decomposition if used according to specifications.
Possibility of hazardous reactions
No dangerous reactions known.
Conditions to avoid
No further relevant information available.
Incompatible materials
strong oxidizing agents, strong reducing agents
Hazardous decomposition products
carbon oxides, nitrogen oxides
Information on toxicological effects
Primary irritant effect
on the skin
No irritant effect.
on the eye
No irritating effect.
Sensitization
No sensitizing effects known.
Additional toxicological information
Carcinogenic categories
IARC (International Agency for Research on Cancer)
Substance is not listed.
NTP (National Toxicology Program)
Substance is not listed.
OSHA-Ca (Occupational Safety & Health Administration)
Substance is not listed.
Toxicity
Aquatic toxicity
No further relevant information available.
Persistence and degradability
No further relevant information available.
Behavior in environmental systems
Bioaccumulative potential
No further relevant information available.
Mobility in soil
No further relevant information available.
Additional ecological information
General notes
Water hazard class 3 (Self-assessment) extremely hazardous for water
Do not allow product to reach ground water, water course or sewage system, even in small quantities.
Danger to drinking water if even extremely small quantities leak into the ground.
Do not allow product to reach ground water, water course or sewage system, even in small quantities.
Danger to drinking water if even extremely small quantities leak into the ground.
Results of PBT and vPvB assessment
PBT
Not applicable.
vPvB
Not applicable.
PBT:
Not applicable.
vPvB:
Not applicable.
Other adverse effects
No further relevant information available.
Waste treatment methods
Recommendation
Must not be disposed of together with household garbage. Do not allow product to reach sewage system.
Uncleaned packagings
Recommendation
Disposal must be made according to official regulations.
UN-Number
DOT, IMDG, IATA UN2811
UN proper shipping name
DOT Toxic solids, organic, n.o.s. (7-epi Paclitaxel)
IMDG TOXIC SOLID, ORGANIC, N.O.S. (7-epi Paclitaxel)
IATA Toxic solid, organic, n.o.s. (7-epi Paclitaxel)
IMDG TOXIC SOLID, ORGANIC, N.O.S. (7-epi Paclitaxel)
IATA Toxic solid, organic, n.o.s. (7-epi Paclitaxel)
Transport hazard class(es)
DOTClass: 6.1 Toxic substances
Label: 6.1
IMDG, IATA
Label: 6.1
Class: 6.1 Toxic substances
Label: 6.1
Label: 6.1
Packing group
DOT, IMDG, IATA III
Environmental hazards
Not applicable.
Special precautions for user
Warning: Toxic substances
Hazard identification number (Kemler code)
60
EMS Number
F-A,S-A
Stowage Category
A
Transport in bulk according to Annex II of MARPOL73/78 and the IBC Code
Not applicable.
Transport/Additional information
DOT:
Quantity limitations
On passenger aircraft/rail: 100 kg
On cargo aircraft only: 200 kg
On cargo aircraft only: 200 kg
IMDG:
Limited quantities (LQ)
5 kg
Excepted quantities (EQ)
Code: E1
Maximum net quantity per inner packaging: 30 g
Maximum net quantity per outer packaging: 1000 g
Maximum net quantity per inner packaging: 30 g
Maximum net quantity per outer packaging: 1000 g
IATA:
Remarks
When sold in quantities of less than or equal to 1 mL, or 1 g, with an Excepted Quantity Code of
E1, E2, E4, or E5, this item meets the De Minimis
Quantities exemption, per IATA 2.6.10.
Therefore packaging does not have to be labeled as
Dangerous Goods/Excepted Quantity.
E1, E2, E4, or E5, this item meets the De Minimis
Quantities exemption, per IATA 2.6.10.
Therefore packaging does not have to be labeled as
Dangerous Goods/Excepted Quantity.
UN "Model Regulation"
UN 2811 TOXIC SOLID, ORGANIC, N.O.S. (7-EPI
PACLITAXEL), 6.1, III
PACLITAXEL), 6.1, III
Safety, health and environmental regulations/legislation specific for the substance or mixture
No further relevant information available.
Sara
| Section 355 (extremely hazardous substances): | Substance is not listed. |
| Section 313 (Specific toxic chemical listings): | Substance is not listed. |
| TSCA (Toxic Substances Control Act): | Substance is not listed. |
| Hazardous Air Pollutants: | Substance is not listed. |
Proposition 65
| Chemicals known to cause cancer: | Substance is not listed. |
| Chemicals known to cause reproductive toxicity for females: | Substance is not listed. |
| Chemicals known to cause reproductive toxicity for males: | Substance is not listed. |
| Chemicals known to cause developmental toxicity: | Substance is not listed. |
Chemicals known to cause cancer
Substance is not listed.
Chemicals known to cause reproductive toxicity for females
Substance is not listed.
Chemicals known to cause reproductive toxicity for males
Substance is not listed.
Chemicals known to cause developmental toxicity
Substance is not listed.
Carcinogenic categories
| EPA (Environmental Protection Agency): | Substance is not listed. |
TLV (Threshold Limit Value)
Substance is not listed.
NIOSH-Ca (National Institute for Occupational Safety and Health)
Substance is not listed.
Chemical safety assessment
A Chemical Safety Assessment has not been carried out.
Abbreviations and acronyms
IMDG: International Maritime Code for Dangerous Goods
DOT: US Department of Transportation
IATA: International Air Transport Association
EINECS: European Inventory of Existing Commercial Chemical Substances
CAS: Chemical Abstracts Service (division of the American Chemical Society)
NFPA: National Fire Protection Association (USA)
HMIS: Hazardous Materials Identification System (USA)
PBT: Persistent, Bioaccumulative and Toxic vPvB: very Persistent and very Bioaccumulative
NIOSH: National Institute for Occupational Safety
OSHA: Occupational Safety & Health
TLV: Threshold Limit Value
PEL: Permissible Exposure Limit
REL: Recommended Exposure Limit
Acute Toxicity - Oral 3: Acute toxicity – Category 3
Germ Cell Mutagenicity 1B: Germ cell mutagenicity – Category 1B
Carcinogenicity 2: Carcinogenicity – Category 2
Toxic to Reproduction 1B: Reproductive toxicity – Category 1B
Specific Target Organ Toxicity - Repeated Exposure 1: Specific target organ toxicity (repeated exposure) – Category 1
DOT: US Department of Transportation
IATA: International Air Transport Association
EINECS: European Inventory of Existing Commercial Chemical Substances
CAS: Chemical Abstracts Service (division of the American Chemical Society)
NFPA: National Fire Protection Association (USA)
HMIS: Hazardous Materials Identification System (USA)
PBT: Persistent, Bioaccumulative and Toxic vPvB: very Persistent and very Bioaccumulative
NIOSH: National Institute for Occupational Safety
OSHA: Occupational Safety & Health
TLV: Threshold Limit Value
PEL: Permissible Exposure Limit
REL: Recommended Exposure Limit
Acute Toxicity - Oral 3: Acute toxicity – Category 3
Germ Cell Mutagenicity 1B: Germ cell mutagenicity – Category 1B
Carcinogenicity 2: Carcinogenicity – Category 2
Toxic to Reproduction 1B: Reproductive toxicity – Category 1B
Specific Target Organ Toxicity - Repeated Exposure 1: Specific target organ toxicity (repeated exposure) – Category 1
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.
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