11.1 Information on toxicological effects
Mixture Acute toxicity
Acute toxicity estimate Oral - 917.17 mg/kg (Calculation method)
Symptoms: Irritations of mucous membranes in the mouth, pharynx, oesophagus and gastrointestinal tract.
Acute toxicity estimate Inhalation - 4 h - 3.13 mg/l - vapor(Calculation method)
Symptoms: Possible symptoms:, mucosal irritations
Dermal: No data available
Skin corrosion/irritation
Remarks: Mixture causes skin irritation.
Serious eye damage/eye irritation
Remarks: Mixture causes serious eye irritation.
Respiratory or skin sensitization
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
Classified based on available data. For more details, see section 2
Carcinogenicity
Evidence of a carcinogenic effect.
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Mixture may cause drowsiness or dizziness.
Specific target organ toxicity - repeated exposure
Mixture causes damage to organs through prolonged or repeated exposure.
Aspiration hazard
Classified based on available data. For more details, see section 2
11.2 Additional Information
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Other dangerous properties can not be excluded.
This substance should be handled with particular care.
Handle in accordance with good industrial hygiene and safety practice.
Components Chloroform
Acute toxicity
LD50 Oral - Rat - male - 908 mg/kg (OECD Test Guideline 401)
LC50 Inhalation - Rat - 6 h - 9.17 mg/l - vapor
Acute toxicity estimate Inhalation - Expert judgment - 4 h - 3.1 mg/l - va- por
Dermal: No data available
Skin corrosion/irritation
Skin - Rabbit
Result: Irritating to skin. - 24 h
Remarks: (ECHA)
Remarks: Drying-out effect resulting in rough and chapped skin.
Skin - Rabbit
Result: slight irritation
Remarks: (IUCLID)
Serious eye damage/eye irritation
Eyes - Rabbit
Result: Irritating to eyes.
Remarks: (ECHA)
Remarks: (Regulation (EC) No 1272/2008, Annex VI)
Respiratory or skin sensitization
Maximization Test - Guinea pig
Result: negative (Regulation (EC) No. 440/2008, Annex, B.6)
Germ cell mutagenicity
Test Type: Ames test
Test system: Escherichia coli/Salmonella typhimurium
Result: negative
Remarks: (ECHA)
Test Type: unscheduled DNA synthesis assay
Test system: Liver
Result: negative
Remarks: (ECHA)
Method: OECD Test Guideline 474
Species: Rat - male and female - Red blood cells (erythrocytes)
Result: negative
Method: OECD Test Guideline 486
Species: Rat - male - Liver cells
Result: negative
Species: Mouse - female
Result: negative
Remarks: (ECHA)
Carcinogenicity
Suspected of causing cancer.
Reproductive toxicity
Suspected of damaging the unborn child.
Specific target organ toxicity - single exposure
May cause drowsiness or dizziness.
Specific target organ toxicity - repeated exposure
Oral - Causes damage to organs through prolonged or repeated exposure.
- Liver, Kidney
Aspiration hazard
Classified based on available data. For more details, see section 2