11.1 Information on toxicological effects
Acute toxicity
LD50 Oral - Rat - male - 107 mg/kg
LC50 Inhalation - Rat - male - 2 h - > 4.5 mg/m3 - aerosol
Dermal: No data available
Skin corrosion/irritation
Classified based on available data. For more details, see section 2
Serious eye damage/eye irritation
Classified based on available data. For more details, see section 2
Respiratory or skin sensitization
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
May alter genetic material.
In vivo tests showed mutagenic effects
Test Type: in vitro assay
Test system: S. typhimurium
Metabolic activation: with and without metabolic activation
Result: negative
Carcinogenicity
This is or contains a component that has been reported to be carcinogenic based on its IARC, OSHA, ACGIH, NTP, or EPA classification. Chronic exposure to cadmi- um may cause lung and prostate cancer.
Possible human carcinogen
Reproductive toxicity
May cause congenital malformation in the fetus.
Presumed human reproductive toxicant
Overexposure may cause reproductive disorder(s) based on tests with laboratory animals.
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Causes damage to organs through prolonged or repeated exposure.
Aspiration hazard
Classified based on available data. For more details, see section 2
11.2 Additional Information
Repeated dose toxicity - Rat - male - Oral - No observed adverse effect level - 0.2 mg/kg - Lowest observed adverse effect level - 0.5 mg/kg
Acute inhalation exposure to cadmium fumes may cause "metal fume fever" with flu-like symptoms of weakness, fever, headache, chills, nausea, vomiting, dizzi- ness, sweating, muscular pain, cough and difficulty breathing. Acute pulmonary edema may develop within 24 hours and reaches a maximum by three days.The first chronic effect of exposure to cadmium is generally kidney damage, manifested by excretion of excessive protein in the urine, followed by anemia, teeth discolora- tion and loss of smell. Cadmium also is believed to cause pulmonary emphysema and bone disease.
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.