ChemicalBook
Chemical Safety Data Sheet MSDS / SDS

DL-4-HYDROXY-3-METHOXYMANDELIC ACID

Revision Date:2026-03-21Revision Number:1

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

  • Product name: DL-4-HYDROXY-3-METHOXYMANDELIC ACID
  • CBnumber: CB6212401
  • CAS: 3695-24-7
  • EINECS Number: 223-017-7
  • Synonyms: iso-VMA;VANILMANDELIC ACID

Relevant identified uses of the substance or mixture and uses advised against

  • Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
  • Uses advised against: none

Company Identification

  • Company: Chemicalbook
  • Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
  • Telephone: 010-86108875

SECTION 2: Hazards identification

GHS Label elements, including precautionary statements

  • Symbol(GHS)
  • Signal wordWarning
Precautionary statements
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
Hazard statements
H335 May cause respiratory irritation
H315 Causes skin irritation
H319 Causes serious eye irritation

SECTION 3: Composition/information on ingredients

Substance

  • Product name: DL-4-HYDROXY-3-METHOXYMANDELIC ACID
  • Synonyms: iso-VMA;VANILMANDELIC ACID
  • CAS: 3695-24-7
  • EC number: 223-017-7
  • MF: C9H10O5
  • MW: 198.17

SECTION 4: First aid measures

First Aid Measures

General advice
Consult a physician if necessary. Remove to fresh air.
Eye contact
Wash with plenty of water.
Skin Contact
Wash skin with soap and water.
Inhalation
Remove to fresh air If breathing is difficult, give oxygen If not breathing, give artificial respiration
Ingestion
Never give anything by mouth to an unconscious person. Clean mouth with water.

Most important symptoms and effects, both acute and delayed

Symptoms
No information available.

Indication of any immediate medical attention and special treatment needed

Note to physicians
Treat symptomatically.

SECTION 5: Firefighting measures

Suitable Extinguishing Media

Suitable Extinguishing Media
Use extinguishing measures that are appropriate to local circumstances and the surrounding environment.
Unsuitable Extinguishing Media
None.

Specific hazards arising from the chemical

Specific hazards arising from the chemical
No information available.
Hazardous combustion products
Carbon oxides.

Explosion data

Sensitivity to Mechanical Impact
No information available.
Sensitivity to Static Discharge
No information available.

Protective equipment and precautions for firefighters

Protective equipment and precautions for firefighters
As in any fire, wear self contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gear.

NFPA 704

1
0
0
HEALTH 1 Exposure would cause irritation with only minor residual injury (e.g. acetone, sodium bromate, potassium chloride)
FIRE 0 Materials that will not burn under typical fire conditions, including intrinsically noncombustible materials such as concrete, stone, and sand. Materials that will not burn in air when exposed to a temperature of 820 °C (1,500 °F) for a period of 5 minutes.(e.g. Carbon tetrachloride)
REACT 0 Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2)
SPEC. HAZ.

SECTION 6: Accidental release measures

Personal precautions, protective equipment and emergency procedures

Personal precautions
Ensure adequate ventilation, especially in confined areas.

Environmental precautions

Environmental precautions
See Section 12 for additional Ecological Information.

Methods and material for containment and cleaning up

Methods for containment
Prevent further leakage or spillage if safe to do so.
Methods for cleaning up
Use personal protective equipment as required. Cover powder spill with plastic sheet or tarp to minimize spreading and keep powder dry. Take up mechanically, placing in appropriate containers for disposal. Avoid creating dust. Clean contaminated surface thoroughly.

SECTION 7: Handling and storage

Precautions for safe handling

Advice on safe handling
Handle in accordance with good industrial hygiene and safety practice.

Conditions for safe storage, including any incompatibilities

Storage Conditions
Protect from moisture. Store at -20 °C.
Incompatible materials
None known based on information supplied.

SECTION 8: Exposure controls/personal protection

Control parameters

Exposure Guidelines
This product, as supplied, does not contain any hazardous materials with occupational exposure limits established by the region specific regulatory bodies.

Appropriate engineering controls

Engineering Controls
Showers
Eyewash stations
Ventilation systems

Individual protection measures, such as personal protective equipment

Eye/face protection
Wear safety glasses with side shields (or goggles).
Skin and Body Protection
Wear protective gloves and protective clothing.
Respiratory protection
If exposure limits are exceeded or irritation is experienced, NIOSH/MSHA approved respiratory protection should be worn. Positive-pressure supplied air respirators may be required for high airborne contaminant concentrations. Respiratory protection must be provided in accordance with current local regulations.
General Hygiene Considerations
Handle in accordance with good industrial hygiene and safety practice.

SECTION 9: Physical and chemical properties

Information on basic physicochemical properties

  • Physical StateSolid
  • AppearanceNo information available
  • OdorNo information available
  • pHNo information available
  • Melting point/freezing point128 °C
  • Boiling point255.48°C (rough estimate)
  • Flash pointNo information available
  • Density1.2539 (rough estimate)
  • Evaporation rateNo information available
  • Upper flammability limitsNo information available
  • Lower flammability limitNo information available
  • Vapor pressureNo information available
  • Vapor densityNo information available
  • Specific gravityNo information available
  • Water solubilityNo information available
  • Solubility in other solventsNo information available
  • Partition coefficientNo information available
  • Autoignition temperatureNo information available
  • Decomposition temperatureNo information available
  • Kinematic viscosityNo information available
  • Explosive propertiesNo information available
  • Oxidizing propertiesNo information available
  • SolubilityH2O: ~50 mg/mL
  • Colourwhite to off-white

SECTION 10: Stability and reactivity

Reactivity

Not applicable

Chemical stability

Stable under recommended storage conditions.

Possibility of Hazardous Reactions

None under normal processing.

Hazardous polymerization

No information available.

Conditions to avoid

Exposure to air or moisture over prolonged periods.

Incompatible materials

Strong oxidizing agents.

Hazardous Decomposition Products

Carbon oxides.

SECTION 11: Toxicological information

Information on likely routes of exposure

Inhalation
Classified based on available data. For more details, see section 2.
Eye contact
Classified based on available data. For more details, see section 2.
Skin Contact
Classified based on available data. For more details, see section 2.
Ingestion
Classified based on available data. For more details, see section 2.

Information on toxicological effects

Symptoms
Classified based on available data. For more details, see section 2.

Delayed and immediate effects as well as chronic effects from short and long-term exposure

Chronic Toxicity
Classified based on available data. For more details, see section 2.

Numerical measures of toxicity - Product Information

Unknown acute toxicity
100% of the mixture consists of ingredient(s) of unknown toxicity

SECTION 12: Ecological information

Ecotoxicity

May cause long lasting harmful effects to aquatic life
100% of the mixture consists of components(s) of unknown hazards to the aquatic environment.

Persistence and degradability

No information available.

Bioaccumulation

No information available.

Mobility

No information available.

SECTION 13: Disposal considerations

Disposal of wastes

Disposal should be in accordance with applicable regional, national and local laws and regulations.

Contaminated packaging

Do not reuse container.

SECTION 14: Transport information

DOT

Not regulated

IMDG

Not regulated

IATA

Not regulated

SECTION 15: Regulatory information

International Inventories

All of the components in the product are on the following Inventory lists
Europe (EINECS/ELINCS/NLP)
X - Listed
TSCA - United States Toxic Substances Control Act Section 8(b) Inventory
DSL/NDSL - Canadian Domestic Substances List/Non-Domestic Substances List
EINECS/ELINCS - European Inventory of Existing Chemical Substances/European List of Notified Chemical Substances
ENCS - Japan Existing and New Chemical Substances
IECSC - China Inventory of Existing Chemical Substances
KECL - Korean Existing and Evaluated Chemical Substances
PICCS - Philippines Inventory of Chemicals and Chemical Substances
Chemical nameTSCADSLNDSLEINECSELINCSENCSIECSCKECLPICCSAICS
3-Hydroxy-4-methoxymandel ic Acid---X------
Chemical nameTSCADSLNDSLEINECSELINCSENCSIECSCKECLPICCSAICS
3-Hydroxy-4-methoxymandel ---X-----icAcid

US Federal Regulations

SARA 313

Section 313 of Title III of the Superfund Amendments and Reauthorization Act of 1986 (SARA). This product does not contain any chemicals which are subject to the reporting requirements of the Act and Title 40 of the Code of Federal Regulations, Part 372.

SARA 311/312 Hazard Categories

Acute health hazard
No
Chronic Health Hazard
No
Fire hazard
No
Sudden release of pressure hazard
No
Reactive hazard
No

CWA (Clean Water Act)

This product does not contain any substances regulated as pollutants pursuant to the Clean Water Act (40 CFR 122.21 and 40
CFR 122.42).

US State Regulations

California Proposition 65

This product does not contain any Proposition 65 chemicals.

U.S. State Right-to-Know Regulations

This product does not contain any substances regulated by state right-to-know regulations

SECTION 16: Other information

Abbreviations and acronyms

CAS: Chemical Abstracts Service
TWA: Time-Weighted Average
STEL: Short-Term Exposure Limit
LD50: Lethal Dose 50%
LC50: Lethal Concentration 50%
EC50: Effective Concentration 50%
PEL: Permissible Exposure Limit
TLV: Threshold Limit Value
IMDG: International Maritime Dangerous Goods Code
IATA: International Air Transport Association
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
DOT: US Department of Transportation
NFPA: National Fire Protection Association
NIOSH: National Institute for Occupational Safety and Health
OSHA: Occupational Safety and Health Administration
Disclaimer:

The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.

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