Chemical Safety Data Sheet MSDS / SDS
Chlorhexidine digluconate
Revision Date:2026-03-22Revision Number:1
Product identifier
- Product name: Chlorhexidine digluconate
- CBnumber: CB9702888
- CAS: 18472-51-0
- EINECS Number: 242-354-0
- Synonyms: CHLORHEXIDINE GLUCONATE;CHLORHEXIDINE GLUCONATE SOLUTION
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordDanger
P501 Dispose of contents/container to..…
P391 Collect spillage. Hazardous to the aquatic environment
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P273 Avoid release to the environment.
Hazard statements
H318 Causes serious eye damage
H410 Very toxic to aquatic life with long lasting effects
Substance
- Product name: Chlorhexidine digluconate
- Synonyms: Chlorhexidine Gluconate,Chlorhexidine Digluconate
- CAS: 18472-51-0
- EC number: 242-354-0
- MF: C22H30Cl2N10.2C6H12O7
- MW: 897.76
General advice
Show this material safety data sheet to the doctor in attendance.
If inhaled
After inhalation: fresh air.
In case of skin contact
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower.
In case of eye contact
After eye contact: rinse out with plenty of water. Immediately call in ophthalmologist. Remove contact lenses.
If swallowed
After swallowing: immediately make victim drink water (two glasses at most). Consult a physician.
Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2) and/or in section 11
Protection of first-aiders
For personal protection see section 8.
Notes to physician
No data available
Suitable extinguishing media
Use extinguishing measures that are appropriate to local circumstances and the surrounding environment.
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.
Specific hazards during fire fighting
Not combustible. Ambient fire may liberate hazardous vapours.
Hazardous combustion products
Carbon oxides Nitrogen oxides (NOx) Hydrogen chloride gas
Specific extinguishing methods
Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.
Special protective equipment for fire-fighters
In the event of fire, wear self-contained breathing apparatus.
NFPA 704
2
0
0
| HEALTH | 2 | Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury (e.g. diethyl ether, ammonium phosphate, iodine) | |
| FIRE | 0 | Materials that will not burn under typical fire conditions, including intrinsically noncombustible materials such as concrete, stone, and sand. Materials that will not burn in air when exposed to a temperature of 820 °C (1,500 °F) for a period of 5 minutes.(e.g. Carbon tetrachloride) | |
| REACT | 0 | Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2) | |
| SPEC. HAZ. |
Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an expert. Advice for emergency responders: For personal protection see section 8.
Environmental precautions
Do not let product enter drains.
Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up with liquid-absorbent material (e.g. Chemizorb® ). Dispose of properly. Clean up affected area.
Handling
Avoidance of contactStrong oxidizing agents
Storage
Further information on storage conditionsTightly closed.
Storage class
12, Non Combustible Liquids
Recommended storage temperature
2 - 8 °C
Further information on storage stability
Light sensitive.
Ingredients with workplace control parameters
Contains no substances with occupational exposure limit values.
Engineering measures
No data available
Personal protective equipment
Respiratory protectionrequired when vapours/aerosols are generated.
Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Recommended Filter type
Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Filter type ABEK
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented.
Eye/face protection
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented.
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Tightly fitting safety goggles
Skin and body protection
Tightly fitting safety goggles
protective clothing
Hand protection
Material
Nitrile rubber
Break through time
480 min
Glove thickness
0.11 mm
Protective index
Full contact
Manufacturer
(KCL 740 / Aldrich Z677272, Size M)
Material
Nitrile rubber
Break through time
480 min
Glove thickness
0.11 mm
Protective index
Splash contact
Manufacturer
(KCL 740 / Aldrich Z677272, Size M)
Manufacturer
data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail sales@kcl.de, test method: EN374
Remarks
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it.
If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the EC approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.
Hygiene measures
The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it.
If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the EC approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.
Change contaminated clothing. Wash hands after working with substance.
Information on basic physicochemical properties
- Viscosity2.51mm2/s
- Physical stateLiquid
- Solubilitywater: soluble50% (w/v)
- Density1.06 g/cm3 (25 °C)
Method: lit. - Relative density1.06 g/mL at 25 °C(lit.)
- Relative vapor densityNo data available
- Vapor pressure0.005Pa at 25℃
- Lower explosion limit / Lower flammability limitNot applicable
- Upper explosion limit / Upper flammability limitNot applicable
- Self-ignitionNot applicable
- Burning rateNo data available
- Flammability (liquids)The product is not flammable.
- Flammability (solid, gas)No data available
- Evaporation rateNo data available
- Flash pointNo data available
- Boiling point/boiling rangeNo data available
- Melting point/ rangeNo data available
- pH5.91 (20 °C)
- Odor ThresholdNo data available
- OdorNo data available
- Colorcolorless light yellow
- Appearanceliquid
- Particle characteristics Particle sizeNo data available
- Oxidizing propertiesnone
- Explosive propertiesNot classified as explosive.
- Flow timeNo data available
- Viscosity, kinematicNo data available
- Viscosity, dynamicNo data available
- Decomposition temperatureNo data available
- Autoignition temperatureNot applicable
- Partition coefficient: n-octanol/waterNo data available
- Water solubilitysoluble (20 °C)
Reactivity
No data available
Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .
Possibility of hazardous reactions
Violent reactions possible with: The generally known reaction partners of water.
Conditions to avoid
no information available
Incompatible materials
Strong oxidizing agents
Hazardous decomposition products
In the event of fire: see section 5
11.1 Information on toxicological effects
Mixture Acute toxicityOral: No data available
Acute toxicity estimate Oral - > 5,000 mg/kg (Calculation method)
Symptoms: Possible symptoms:, mucosal irritations
Dermal: No data available
Skin corrosion/irritation
Acute toxicity estimate Oral - > 5,000 mg/kg (Calculation method)
Symptoms: Possible symptoms:, mucosal irritations
Dermal: No data available
Classified based on available data. For more details, see section 2
Serious eye damage/eye irritation
Remarks: Mixture causes serious eye damage.
Respiratory or skin sensitization
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
Classified based on available data. For more details, see section 2
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
11.2 Additional Information
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Other dangerous properties can not be excluded.
Handle in accordance with good industrial hygiene and safety practice.
Components D-Gluconic acid, compound with N,N''-bis(4-chlorophenyl)-3,12-diimino- 2,4,11,13-tetraazatetradecanediamidine (2:1)
Other dangerous properties can not be excluded.
Handle in accordance with good industrial hygiene and safety practice.
Acute toxicity
LD50 Oral - Rat - male and female - 2,135 mg/kg (OECD Test Guideline 401)
Inhalation: No data available
LD50 Dermal - Rabbit - male and female - > 5,000 mg/kg (US-EPA)
Inhalation: No data available
LD50 Dermal - Rabbit - male and female - > 5,000 mg/kg (US-EPA)
Skin corrosion/irritation
Skin - Rabbit
Result: No irritation - 4 h (OECD Test Guideline 404)
Result: No irritation - 4 h (OECD Test Guideline 404)
Serious eye damage/eye irritation
Remarks: Causes serious eye damage.
Respiratory or skin sensitization
Maximization Test - Guinea pig
Result: negative (OECD Test Guideline 406)
Germ cell mutagenicity
Result: negative (OECD Test Guideline 406)
Test Type: Ames test
Test system: Salmonella typhimurium
Result: negative
Test Type: In vitro mammalian cell gene mutation test
Test system: Chinese hamster fibroblasts
Result: negative
Test Type: Chromosome aberration test in vitro
Result: negative
Method: OECD Test Guideline 474
Species: Mouse - male - Bone marrow
Result: negative
Carcinogenicity
Test system: Salmonella typhimurium
Result: negative
Test Type: In vitro mammalian cell gene mutation test
Test system: Chinese hamster fibroblasts
Result: negative
Test Type: Chromosome aberration test in vitro
Result: negative
Method: OECD Test Guideline 474
Species: Mouse - male - Bone marrow
Result: negative
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
Ecotoxicity
Components:
D-Gluconic acid, compound with N,N''-bis(4-chlorophenyl)-3,12-diimino- 2,4,11,13-tetraazatetradecanediamidine (2:1):
Toxicity to fishLC50 (Danio rerio (zebra fish)): 2.08 mg/l Exposure time: 96 h Test Type: semi-static test Method: OECD Test Guideline 203 GLP: yes
Toxicity to daphnia and other aquatic invertebrates
EC50 (Daphnia magna (Water flea)): 0.087 mg/l Exposure time: 48 h Test Type: static test Analytical monitoring: yes Method: OECD Test Guideline 202 GLP: yes
Toxicity to algae/aquatic plants
EC10 (Desmodesmus subspicatus (green algae)): 0.03 mg/l Exposure time: 72 h Test Type: static test Analytical monitoring: yes Method: OECD Test Guideline 201 GLP: yes ErC50 (Desmodesmus subspicatus (green algae)): 0.081 mg/l Exposure time: 72 h Test Type: static test Analytical monitoring: yes Method: OECD Test Guideline 201 GLP: yes
M-Factor (Acute aquatic toxicity)
10
Toxicity to daphnia and other aquatic invertebrates (Chronic toxicity)
NOEC (Daphnia magna (Water flea)): 0.0206 mg/l Exposure time: 21 d Test Type: semi-static test Analytical monitoring: yes Method: OECD Test Guideline 211 GLP: yes
M-Factor (Chronic aquatic toxicity)
1
Toxicity to microorganisms
EC50 (activated sludge): 25 mg/l Exposure time: 3 h Test Type: static test Method: OECD Test Guideline 209 GLP: yes
Persistence and degradability
No data available
Bioaccumulative potential
Components:
D-Gluconic acid, compound with N,N''-bis(4-chlorophenyl)-3,12-diimino- 2,4,11,13-tetraazatetradecanediamidine (2:1):
BioaccumulationSpecies: Leuciscus idus melanotus Bioconcentration factor (BCF): 42 Exposure time: 3 d Concentration: 50 µg/l
Partition coefficient: noctanol/water
log Pow: -1.81 (20.7 °C) pH: 5.3 - 6.6 Method: OECD Test Guideline 107 Remarks: Bioaccumulation is not expected.
Mobility in soil
Components:
D-Gluconic acid, compound with N,N''-bis(4-chlorophenyl)-3,12-diimino- 2,4,11,13-tetraazatetradecanediamidine (2:1):
Stability in soilRemarks: No data available
Other adverse effects
No data available
Disposal methods
Waste from residuesOffer surplus and non-recyclable solutions to a licensed disposal company.
International Regulations
IATA-DGR
UN/ID No. : UN 3082
Proper shipping name : Environmentally hazardous substance, liquid, n.o.s.
(D-Gluconic acid, compound with N,N''-bis(4chlorophenyl)-3,12-diimino-2,4,11,13tetraazatetradecanediamidine (2:1))
Class : 9
Packing group : III
Labels : Class 9 - Miscellaneous dangerous substances and articles
Packing instruction (cargo aircraft) : 964
Packing instruction (passenger aircraft) : 964
Proper shipping name : Environmentally hazardous substance, liquid, n.o.s.
(D-Gluconic acid, compound with N,N''-bis(4chlorophenyl)-3,12-diimino-2,4,11,13tetraazatetradecanediamidine (2:1))
Class : 9
Packing group : III
Labels : Class 9 - Miscellaneous dangerous substances and articles
Packing instruction (cargo aircraft) : 964
Packing instruction (passenger aircraft) : 964
IMDG-Code
UN number : UN 3082
Proper shipping name : ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID, N.O.S.
(D-Gluconic acid, compound with N,N''-bis(4chlorophenyl)-3,12-diimino-2,4,11,13tetraazatetradecanediamidine (2:1))
Class : 9
Packing group : III
Labels : 9
EmS Code : F-A, S-F
Marine pollutant : yes
Proper shipping name : ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID, N.O.S.
(D-Gluconic acid, compound with N,N''-bis(4chlorophenyl)-3,12-diimino-2,4,11,13tetraazatetradecanediamidine (2:1))
Class : 9
Packing group : III
Labels : 9
EmS Code : F-A, S-F
Marine pollutant : yes
Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not applicable for product as supplied.
National regulation GB 6944/12268
UN number : UN 3082
Proper shipping name : ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID, N.O.S.
(D-Gluconic acid, compound with N,N''-bis(4chlorophenyl)-3,12-diimino-2,4,11,13tetraazatetradecanediamidine (2:1))
Class : 9
Packing group : III
Labels : 9
National regulation GB 6944/12268
UN number : UN 3082
Proper shipping name : ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID, N.O.S.
(D-Gluconic acid, compound with N,N''-bis(4chlorophenyl)-3,12-diimino-2,4,11,13tetraazatetradecanediamidine (2:1))
Class : 9
Packing group : III
Labels : 9
Special precautions for user
Remarks : EHS-Mark required (ADR 2.2.9.1.10, IMDG code 2.10.3) for single packagings and combination packagings containing inner packagings with Dangerous
Goods > 5L for liquids or > 5kg for solids.
Packages smaller than or equal to 5 kg / L , not dangerous goods of Class 9
The transport classification(s) provided herein are for informational purposes only, and solely based upon the properties of the unpackaged material as it is described within this Safety Data Sheet. Transportation classifications may vary by mode of transportation, package sizes, and variations in regional or country regulations.
Goods > 5L for liquids or > 5kg for solids.
Packages smaller than or equal to 5 kg / L , not dangerous goods of Class 9
The transport classification(s) provided herein are for informational purposes only, and solely based upon the properties of the unpackaged material as it is described within this Safety Data Sheet. Transportation classifications may vary by mode of transportation, package sizes, and variations in regional or country regulations.
National regulatory information
Regulations on Safety Management of Hazardous Chemicals
Full text of other abbreviations
AIIC - Australian Inventory of Industrial Chemicals
ANTT - National Agency forTransport by Land of Brazil
ASTM - American Society for the Testing of Materials
bw - Body weight
CMR - Carcinogen, Mutagen or Reproductive Toxicant
DIN -Standard of the German Institute for Standardisation
DSL - Domestic SubstancesList (Canada)
ECx - Concentration associated with x% response
ELx - Loading rate associated with x% response
EmS - Emergency Schedule
ENCS - Existing and NewChemical Substances (Japan)
ErCx - Concentration associated with x% growth rate response
ERG - Emergency Response Guide
GHS - Globally Harmonized System
GLP - Good Laboratory Practice
IARC - International Agency for Research on Can- cer
IATA - International Air Transport Association
IBC - International Code for theConstruction and Equipment of Ships carrying Dangerous Chemicals in Bulk
IC50 -Half maximal inhibitory concentration
ICAO - International Civil Aviation Organiza- tion
IECSC - Inventory of Existing Chemical Substances in China
IMDG - Interna- tional Maritime Dangerous Goods
IMO - International Maritime Organization
ISHL -Industrial Safety and Health Law (Japan)
ISO - International Organisation forStandardization
KECI - Korea Existing Chemicals Inventory
LC50 - Lethal Concen- tration to 50 % of a test population
LD50 - Lethal Dose to 50% of a test population (Median Lethal Dose)
MARPOL - International Convention for the Prevention of Pol- lution from Ships
n.o.s. - Not Otherwise Specified
Nch - Chilean Norm
NO(A)EC -No Observed (Adverse) Effect Concentration
NO(A)EL - No Observed (Adverse) Ef- fect Level
NOELR - No Observable Effect Loading Rate
NOM - Official MexicanNorm
NTP - National Toxicology Program
NZIoC - New Zealand Inventory of Chem- icals
OECD - Organization for Economic Co-operation and Development
OPPTS - Of- fice of Chemical Safety and Pollution Prevention
PBT - Persistent, Bioaccumulative and Toxic substance
PICCS - Philippines Inventory of Chemicals and Chemical Sub- stances
(Q)SAR - (Quantitative) Structure Activity Relationship
REACH - Regulation (EC) No 1907/2006 of the European Parliament and of the Council concerning theRegistration, Evaluation, Authorisation and Restriction of Chemicals
SADT - Self-Accelerating Decomposition Temperature
SDS - Safety Data Sheet
TCSI - TaiwanChemical Substance Inventory
TDG - Transportation of Dangerous Goods
TECI -Thailand Existing Chemicals Inventory
TSCA - Toxic Substances Control Act (UnitedStates)
UN - United Nations
UNRTDG - United Nations Recommendations on theTransport of Dangerous Goods
vPvB - Very Persistent and Very Bioaccumulative
WHMIS - Workplace Hazardous Materials Information System
ANTT - National Agency forTransport by Land of Brazil
ASTM - American Society for the Testing of Materials
bw - Body weight
CMR - Carcinogen, Mutagen or Reproductive Toxicant
DIN -Standard of the German Institute for Standardisation
DSL - Domestic SubstancesList (Canada)
ECx - Concentration associated with x% response
ELx - Loading rate associated with x% response
EmS - Emergency Schedule
ENCS - Existing and NewChemical Substances (Japan)
ErCx - Concentration associated with x% growth rate response
ERG - Emergency Response Guide
GHS - Globally Harmonized System
GLP - Good Laboratory Practice
IARC - International Agency for Research on Can- cer
IATA - International Air Transport Association
IBC - International Code for theConstruction and Equipment of Ships carrying Dangerous Chemicals in Bulk
IC50 -Half maximal inhibitory concentration
ICAO - International Civil Aviation Organiza- tion
IECSC - Inventory of Existing Chemical Substances in China
IMDG - Interna- tional Maritime Dangerous Goods
IMO - International Maritime Organization
ISHL -Industrial Safety and Health Law (Japan)
ISO - International Organisation forStandardization
KECI - Korea Existing Chemicals Inventory
LC50 - Lethal Concen- tration to 50 % of a test population
LD50 - Lethal Dose to 50% of a test population (Median Lethal Dose)
MARPOL - International Convention for the Prevention of Pol- lution from Ships
n.o.s. - Not Otherwise Specified
Nch - Chilean Norm
NO(A)EC -No Observed (Adverse) Effect Concentration
NO(A)EL - No Observed (Adverse) Ef- fect Level
NOELR - No Observable Effect Loading Rate
NOM - Official MexicanNorm
NTP - National Toxicology Program
NZIoC - New Zealand Inventory of Chem- icals
OECD - Organization for Economic Co-operation and Development
OPPTS - Of- fice of Chemical Safety and Pollution Prevention
PBT - Persistent, Bioaccumulative and Toxic substance
PICCS - Philippines Inventory of Chemicals and Chemical Sub- stances
(Q)SAR - (Quantitative) Structure Activity Relationship
REACH - Regulation (EC) No 1907/2006 of the European Parliament and of the Council concerning theRegistration, Evaluation, Authorisation and Restriction of Chemicals
SADT - Self-Accelerating Decomposition Temperature
SDS - Safety Data Sheet
TCSI - TaiwanChemical Substance Inventory
TDG - Transportation of Dangerous Goods
TECI -Thailand Existing Chemicals Inventory
TSCA - Toxic Substances Control Act (UnitedStates)
UN - United Nations
UNRTDG - United Nations Recommendations on theTransport of Dangerous Goods
vPvB - Very Persistent and Very Bioaccumulative
WHMIS - Workplace Hazardous Materials Information System
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.