11.1 Information on toxicological effects
Acute toxicity
Acute toxicity estimate Oral - 5.1 mg/kg (Expert judgment)
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
The value is given in analogy to the following substances: Copper cyanide
Acute toxicity estimate Inhalation - 4 h - 0.051 mg/l - dust/mist (Expert judgment)
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
The value is given in analogy to the following substances: Copper cyanide
Symptoms: mucosal irritations, Cough, Shortness of breath
Acute toxicity estimate Dermal - 5.1 mg/kg (Expert judgment)
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
The value is given in analogy to the following substances: Copper cyanide
Skin corrosion/irritation
Skin - Rabbit
Result: No skin irritation - 4 h (OECD Test Guideline 404)
Remarks: The value is given in analogy to the following substances: Copper cyanide
Serious eye damage/eye irritation
Eyes - Rabbit
Result: No eye irritation - 1 s (OECD Test Guideline 405)
Remarks: The value is given in analogy to the following substances: Copper cyanide
Respiratory or skin sensitization
Buehler Test - Guinea pig
Result: negative (OECD Test Guideline 406)
Remarks: The value is given in analogy to the following substances: Copper cyanide
Germ cell mutagenicity
Test Type: Ames test
Test system: Escherichia coli/Salmonella typhimurium
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 471
Result: negative
Remarks: The value is given in analogy to the following substances: Copper cyanideTest
Type: Chromosome aberration test in vitro
Test system: Chinese hamster lung cells
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 473
Result: negative
Remarks: The value is given in analogy to the following substances: Copper cyanide
Test Type: Chromosome aberration test in vitro
Species: Rat
Application Route: Gavage
Method: OECD Test Guideline 475
Result: negative
Remarks: The value is given in analogy to the following substances: Copper cyanide
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Oral - May cause damage to organs through prolonged or repeated exposure.
- Liver, spleen, Bone marrow
Remarks: The value is given in analogy to the following substances: Copper cyanide
Aspiration hazard
Classified based on available data. For more details, see section 2
11.2 Additional Information
Repeated dose toxicity - Rat - male and female - Gavage - NOAEL (No observed adverse effect level) - 16 mg/kg
Remarks: The value is given in analogy to the following substances: Copper cyanide
Symptoms of systemic copper poisoning may include: capillary damage, headache, cold sweat, weak pulse, and kidney and liver damage, central nervous system excitation followed by depression, jaundice, convulsions, paralysis, and coma. Death may occur from shock or renal failure. Chronic copper poisoning is typified by hepatic cirrhosis, brain damage and demyelination, kidney defects, and copper deposition in the cornea as exemplified by humans with Wilson's disease. It has also been reported that copper poisoning has lead to hemolytic anemia and accelerates arteriosclerosis., Dermatitis, To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
After absorption:
Headache
Dizziness
Impairment of vision
Shortness of breath
Unconsciousness
Convulsions death
The following applies to cyanogen compounds/ nitriles in general: utmost caution! Release of hydrocyanic acid is possible - blockade of cellular respiration. Cardiovascular disorders, dyspnoea, unconsciousness.
This substance should be handled with particular care.