11.1 Information on toxicological effects
Acute toxicity
LD50 Oral - Rat - 17 mg/kg
Remarks: (RTECS)
The value is given in analogy to the following substances: Dichlorvos
Acute toxicity estimate Inhalation - 4 h - 0.51 mg/l - vapor (Expert judgment)
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
The value is given in analogy to the following substances: Dichlorvos
LD50 Dermal - Rabbit - 107 mg/kg
Remarks: (RTECS)
The value is given in analogy to the following substances: Dichlorvos
Skin corrosion/irritation
Classified based on available data. For more details, see section 2
Serious eye damage/eye irritation
Classified based on available data. For more details, see section 2
Respiratory or skin sensitization
May cause allergic skin reaction. Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2) The value is given in analogy to the following substances:
Germ cell mutagenicity
Classified based on available data. For more details, see section 2
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
11.2 Additional Information
Cholinesterase inhibitors can cause heavy salivation and secretion in the lungs, lachrymation, blurred vision, involuntary defecation, diarrhea, tremor, ataxia, sweating, hypothermia, lowered heart rate, and/or a fall in blood pressure as a re- sult of their action at cholinergic nerve sites., Absorption into the body leads to the formation of methemoglobin which in sufficient concentration causes cyanosis. On- set may be delayed 2 to 4 hours or longer., Salivation, Coma., Tremors, Incoordi- nation., Blurred vision, Lowered blood pressure, Diarrhea, Headache, Weakness,
Unconsciousness, Palpitation, Anorexia., Convulsions, sweating, Muscle cramps/spasms., Change in pupil size., Nausea, Vomiting, Dizziness, Drowsiness,
Confusion.
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.